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Protein

G-protein coupled bile acid receptor 1

Gene

GPBAR1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for bile acid. Bile-acid binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled bile acid receptor 1
Gene namesi
Name:GPBAR1
Synonyms:TGR5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 50CytoplasmicSequence analysis10
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 85ExtracellularSequence analysisAdd BLAST14
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 125CytoplasmicSequence analysisAdd BLAST19
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 169ExtracellularSequence analysisAdd BLAST23
Transmembranei170 – 190Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini191 – 230CytoplasmicSequence analysisAdd BLAST40
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 261ExtracellularSequence analysis10
Transmembranei262 – 282Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini283 – 330CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695021 – 330G-protein coupled bile acid receptor 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi85 ↔ 155PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed at high level in spleen. Expressed at lower level in thymus, heart, lung, liver, kidney, ileum, blood and adherent alveolar macrophage cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004791.

Structurei

3D structure databases

ProteinModelPortaliQ862A8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAJ. Eukaryota.
ENOG411075X. LUCA.
HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ862A8.
KOiK08400.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q862A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPNSTGEVP GPIPRGALEL SLALASLIIA ANLLLALGIA CDRRLRSPPA
60 70 80 90 100
GCFFLSLLLA GLLTGLALPT LPGLWRQSHR GYWSCLLVYL APNFSFLSLL
110 120 130 140 150
ANLLLVHGER YVAVLRPLQP PGSIRLALLL TWTGPLLFAS LPALGWNHWG
160 170 180 190 200
PEANCSSQTI FPAPYLYLEV YGLLLPAVGA AALLSAHVLL AAHRQLQDIR
210 220 230 240 250
RLERAVCRDA PSALARALTW RQARAQAGAT LLFGLCWGPY VATLFLSVLA
260 270 280 290 300
YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDHRYTAP WRAAARRWLR
310 320 330
GLRGRGSQAS PGPSTAYHTS SQSSVDVDLN
Length:330
Mass (Da):35,224
Last modified:June 1, 2003 - v1
Checksum:i432072D08CEE0FB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089309 mRNA. Translation: BAC55237.1.
RefSeqiNP_001076117.1. NM_001082648.1.
UniGeneiOcu.3068.

Genome annotation databases

GeneIDi100009346.
KEGGiocu:100009346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089309 mRNA. Translation: BAC55237.1.
RefSeqiNP_001076117.1. NM_001082648.1.
UniGeneiOcu.3068.

3D structure databases

ProteinModelPortaliQ862A8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004791.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009346.
KEGGiocu:100009346.

Organism-specific databases

CTDi151306.

Phylogenomic databases

eggNOGiENOG410IZAJ. Eukaryota.
ENOG411075X. LUCA.
HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ862A8.
KOiK08400.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPBAR_RABIT
AccessioniPrimary (citable) accession number: Q862A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: November 11, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.