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Q861Q8

- OPTN_MACMU

UniProt

Q861Q8 - OPTN_MACMU

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Protein
Optineurin
Gene
OPTN
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD) By similarity.

GO - Biological processi

  1. Golgi ribbon formation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Gene namesi
Name:OPTN
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 9

Subcellular locationi

Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity. Golgi apparatustrans-Golgi network By similarity
Note: Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane By similarity.

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  2. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Optineurin
PRO_0000058068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei177 – 1771Phosphoserine; by TBK1 By similarity

Post-translational modificationi

Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ861Q8.

Expressioni

Tissue specificityi

Present in aqueous humor of the eye (at protein level).1 Publication

Interactioni

Subunit structurei

Interacts with HD. Interacts with Rab8 (RAB8A and/or RAB8B). Interacts with transcription factor IIIA (GTF3A). Interacts with TRAF3, TBK1 and MYO6. Binds to ubiquitin By similarity.

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000036258.

Structurei

3D structure databases

ProteinModelPortaliQ861Q8.
SMRiQ861Q8. Positions 545-571.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni406 – 514109Interaction with MYO6 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili38 – 170133 Reviewed prediction
Add
BLAST
Coiled coili233 – 502270 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi468 – 4736UBAN

Domaini

Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1 By similarity.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138369.
GeneTreeiENSGT00530000063808.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
OrthoDBiEOG7D2FD7.

Family and domain databases

InterProiIPR021063. NEMO_N.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q861Q8-1 [UniParc]FASTAAdd to Basket

« Hide

MSHQPLSCLT EKGDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE    50
NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFETQS KEAKERLMAL 100
SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVTRL 150
QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG 200
PTRTVSIGTS RSAEGAKNYL EHEELTVSQL LLCLREGNQK VERLEIALKE 250
AKERVSDFEK KASNRSEIET QTEGSTEKEN EEEKGPETVG SEVEALNLQV 300
TSLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY 350
TNKKLELQVE SMLSEIKMEQ AKTEDEKSKL AMLQLTHNKL LQEHNHALKT 400
IEELTRKESE KVDRAVLKEL SEKLELAEKA LASKQLQMDE MKQTIAKQEE 450
DLETMTVLRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKENDAF 500
EDGGRQSLME MQSRHGARTS DPDQQAYLVQ RGTEDRDWQQ QRNIPIHSCP 550
KCGEVLPDID TLQIHVMDCI I 571
Length:571
Mass (Da):65,104
Last modified:June 1, 2003 - v1
Checksum:iFB8B1305CFF7AE6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY228374 mRNA. Translation: AAO73054.1.
AY228373 mRNA. Translation: AAO73053.1.
AY749122
, AY749110, AY749111, AY749112, AY749113, AY749114, AY749115, AY749116, AY749117, AY749118, AY749119, AY749120, AY749121 Genomic DNA. Translation: AAV28653.1.
RefSeqiNP_001028069.1. NM_001032897.1.
UniGeneiMmu.3672.

Genome annotation databases

EnsembliENSMMUT00000043250; ENSMMUP00000036259; ENSMMUG00000005601.
GeneIDi574252.
KEGGimcc:574252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY228374 mRNA. Translation: AAO73054.1 .
AY228373 mRNA. Translation: AAO73053.1 .
AY749122
, AY749110 , AY749111 , AY749112 , AY749113 , AY749114 , AY749115 , AY749116 , AY749117 , AY749118 , AY749119 , AY749120 , AY749121 Genomic DNA. Translation: AAV28653.1 .
RefSeqi NP_001028069.1. NM_001032897.1.
UniGenei Mmu.3672.

3D structure databases

ProteinModelPortali Q861Q8.
SMRi Q861Q8. Positions 545-571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000036258.

Proteomic databases

PRIDEi Q861Q8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000043250 ; ENSMMUP00000036259 ; ENSMMUG00000005601 .
GeneIDi 574252.
KEGGi mcc:574252.

Organism-specific databases

CTDi 10133.

Phylogenomic databases

eggNOGi NOG138369.
GeneTreei ENSGT00530000063808.
HOGENOMi HOG000231899.
HOVERGENi HBG106481.
OrthoDBi EOG7D2FD7.

Miscellaneous databases

NextBioi 19977879.

Family and domain databases

InterProi IPR021063. NEMO_N.
[Graphical view ]
Pfami PF11577. NEMO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic structure of optineurin (OPTN) in Rhesus monkey."
    Rezaie T., Sarfarazi M.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiOPTN_MACMU
AccessioniPrimary (citable) accession number: Q861Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3