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Q861Q8

- OPTN_MACMU

UniProt

Q861Q8 - OPTN_MACMU

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Protein

Optineurin

Gene

OPTN

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52 (By similarity).By similarity

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. Golgi ribbon formation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Optineurin
Gene namesi
Name:OPTN
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 9

Subcellular locationi

Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity. Golgi apparatustrans-Golgi network By similarity. Cytoplasmic vesicleautophagosome By similarity. Cytoplasmic vesicle By similarity. Recycling endosome By similarity
Note: Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. endosome Source: UniProtKB-KW
  3. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571OptineurinPRO_0000058068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei177 – 1771Phosphoserine; by TBK1By similarity

Post-translational modificationi

Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ861Q8.

Expressioni

Tissue specificityi

Present in aqueous humor of the eye (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ861Q8. baseline.

Interactioni

Subunit structurei

Interacts with HD, Rab8 (RAB8A and/or RAB8B) (active GTP-bound form), GTF3A, TRAF3, TBK1, MYO6 and TFRC. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the asscociation (at least with MAP1LC3B). Self-associates. Interacts with RAB12; the interaction may be indirect (By similarity).By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000036258.

Structurei

3D structure databases

ProteinModelPortaliQ861Q8.
SMRiQ861Q8. Positions 545-571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 209152Interaction with Rab8By similarityAdd
BLAST
Regioni405 – 571167Interaction with HDBy similarityAdd
BLAST
Regioni406 – 514109Interaction with MYO6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili38 – 170133Sequence AnalysisAdd
BLAST
Coiled coili233 – 502270Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1816LIR
Motifi468 – 4736UBAN

Domaini

The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.By similarity
Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138369.
GeneTreeiENSGT00530000063808.
HOGENOMiHOG000231899.
HOVERGENiHBG106481.
InParanoidiQ861Q8.
OrthoDBiEOG7D2FD7.

Family and domain databases

InterProiIPR021063. NEMO_N.
[Graphical view]
PfamiPF11577. NEMO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q861Q8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHQPLSCLT EKGDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE
60 70 80 90 100
NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFETQS KEAKERLMAL
110 120 130 140 150
SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVTRL
160 170 180 190 200
QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG
210 220 230 240 250
PTRTVSIGTS RSAEGAKNYL EHEELTVSQL LLCLREGNQK VERLEIALKE
260 270 280 290 300
AKERVSDFEK KASNRSEIET QTEGSTEKEN EEEKGPETVG SEVEALNLQV
310 320 330 340 350
TSLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY
360 370 380 390 400
TNKKLELQVE SMLSEIKMEQ AKTEDEKSKL AMLQLTHNKL LQEHNHALKT
410 420 430 440 450
IEELTRKESE KVDRAVLKEL SEKLELAEKA LASKQLQMDE MKQTIAKQEE
460 470 480 490 500
DLETMTVLRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKENDAF
510 520 530 540 550
EDGGRQSLME MQSRHGARTS DPDQQAYLVQ RGTEDRDWQQ QRNIPIHSCP
560 570
KCGEVLPDID TLQIHVMDCI I
Length:571
Mass (Da):65,104
Last modified:June 1, 2003 - v1
Checksum:iFB8B1305CFF7AE6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228374 mRNA. Translation: AAO73054.1.
AY228373 mRNA. Translation: AAO73053.1.
AY749122
, AY749110, AY749111, AY749112, AY749113, AY749114, AY749115, AY749116, AY749117, AY749118, AY749119, AY749120, AY749121 Genomic DNA. Translation: AAV28653.1.
RefSeqiNP_001028069.1. NM_001032897.1.
UniGeneiMmu.3672.

Genome annotation databases

EnsembliENSMMUT00000043250; ENSMMUP00000036259; ENSMMUG00000005601.
GeneIDi574252.
KEGGimcc:574252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228374 mRNA. Translation: AAO73054.1 .
AY228373 mRNA. Translation: AAO73053.1 .
AY749122
, AY749110 , AY749111 , AY749112 , AY749113 , AY749114 , AY749115 , AY749116 , AY749117 , AY749118 , AY749119 , AY749120 , AY749121 Genomic DNA. Translation: AAV28653.1 .
RefSeqi NP_001028069.1. NM_001032897.1.
UniGenei Mmu.3672.

3D structure databases

ProteinModelPortali Q861Q8.
SMRi Q861Q8. Positions 545-571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000036258.

Proteomic databases

PRIDEi Q861Q8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000043250 ; ENSMMUP00000036259 ; ENSMMUG00000005601 .
GeneIDi 574252.
KEGGi mcc:574252.

Organism-specific databases

CTDi 10133.

Phylogenomic databases

eggNOGi NOG138369.
GeneTreei ENSGT00530000063808.
HOGENOMi HOG000231899.
HOVERGENi HBG106481.
InParanoidi Q861Q8.
OrthoDBi EOG7D2FD7.

Miscellaneous databases

NextBioi 19977879.

Gene expression databases

ExpressionAtlasi Q861Q8. baseline.

Family and domain databases

InterProi IPR021063. NEMO_N.
[Graphical view ]
Pfami PF11577. NEMO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic structure of optineurin (OPTN) in Rhesus monkey."
    Rezaie T., Sarfarazi M.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiOPTN_MACMU
AccessioniPrimary (citable) accession number: Q861Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3