Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q861Q8

- OPTN_MACMU

UniProt

Q861Q8 - OPTN_MACMU

Protein

Optineurin

Gene

OPTN

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52 By similarity.By similarity

    GO - Biological processi

    1. Golgi ribbon formation Source: UniProtKB

    Keywords - Biological processi

    Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Optineurin
    Gene namesi
    Name:OPTN
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 9

    Subcellular locationi

    Cytoplasmperinuclear region By similarity. Golgi apparatus By similarity. Golgi apparatustrans-Golgi network By similarity. Cytoplasmic vesicleautophagosome By similarity. Cytoplasmic vesicle By similarity. Recycling endosome By similarity
    Note: Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy By similarity.By similarity

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    2. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 571571OptineurinPRO_0000058068Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei177 – 1771Phosphoserine; by TBK1By similarity

    Post-translational modificationi

    Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ861Q8.

    Expressioni

    Tissue specificityi

    Present in aqueous humor of the eye (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Interacts with HD, Rab8 (RAB8A and/or RAB8B) (active GTP-bound form), GTF3A, TRAF3, TBK1, MYO6 and TFRC. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the asscociation (at least with MAP1LC3B). Self-associates. Interacts with RAB12; the interaction may be indirect By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000036258.

    Structurei

    3D structure databases

    ProteinModelPortaliQ861Q8.
    SMRiQ861Q8. Positions 545-571.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 209152Interaction with Rab8By similarityAdd
    BLAST
    Regioni405 – 571167Interaction with HDBy similarityAdd
    BLAST
    Regioni406 – 514109Interaction with MYO6By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili38 – 170133Sequence AnalysisAdd
    BLAST
    Coiled coili233 – 502270Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi176 – 1816LIR
    Motifi468 – 4736UBAN

    Domaini

    The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.By similarity
    Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.By similarity

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG138369.
    GeneTreeiENSGT00530000063808.
    HOGENOMiHOG000231899.
    HOVERGENiHBG106481.
    OrthoDBiEOG7D2FD7.

    Family and domain databases

    InterProiIPR021063. NEMO_N.
    [Graphical view]
    PfamiPF11577. NEMO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q861Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHQPLSCLT EKGDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE    50
    NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFETQS KEAKERLMAL 100
    SHENEKLKEE LGKLKGKSER SSEDPTDDSR LPRAEAEQEK DQLRTQVTRL 150
    QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG 200
    PTRTVSIGTS RSAEGAKNYL EHEELTVSQL LLCLREGNQK VERLEIALKE 250
    AKERVSDFEK KASNRSEIET QTEGSTEKEN EEEKGPETVG SEVEALNLQV 300
    TSLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY 350
    TNKKLELQVE SMLSEIKMEQ AKTEDEKSKL AMLQLTHNKL LQEHNHALKT 400
    IEELTRKESE KVDRAVLKEL SEKLELAEKA LASKQLQMDE MKQTIAKQEE 450
    DLETMTVLRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKENDAF 500
    EDGGRQSLME MQSRHGARTS DPDQQAYLVQ RGTEDRDWQQ QRNIPIHSCP 550
    KCGEVLPDID TLQIHVMDCI I 571
    Length:571
    Mass (Da):65,104
    Last modified:June 1, 2003 - v1
    Checksum:iFB8B1305CFF7AE6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY228374 mRNA. Translation: AAO73054.1.
    AY228373 mRNA. Translation: AAO73053.1.
    AY749122
    , AY749110, AY749111, AY749112, AY749113, AY749114, AY749115, AY749116, AY749117, AY749118, AY749119, AY749120, AY749121 Genomic DNA. Translation: AAV28653.1.
    RefSeqiNP_001028069.1. NM_001032897.1.
    UniGeneiMmu.3672.

    Genome annotation databases

    EnsembliENSMMUT00000043250; ENSMMUP00000036259; ENSMMUG00000005601.
    GeneIDi574252.
    KEGGimcc:574252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY228374 mRNA. Translation: AAO73054.1 .
    AY228373 mRNA. Translation: AAO73053.1 .
    AY749122
    , AY749110 , AY749111 , AY749112 , AY749113 , AY749114 , AY749115 , AY749116 , AY749117 , AY749118 , AY749119 , AY749120 , AY749121 Genomic DNA. Translation: AAV28653.1 .
    RefSeqi NP_001028069.1. NM_001032897.1.
    UniGenei Mmu.3672.

    3D structure databases

    ProteinModelPortali Q861Q8.
    SMRi Q861Q8. Positions 545-571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000036258.

    Proteomic databases

    PRIDEi Q861Q8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000043250 ; ENSMMUP00000036259 ; ENSMMUG00000005601 .
    GeneIDi 574252.
    KEGGi mcc:574252.

    Organism-specific databases

    CTDi 10133.

    Phylogenomic databases

    eggNOGi NOG138369.
    GeneTreei ENSGT00530000063808.
    HOGENOMi HOG000231899.
    HOVERGENi HBG106481.
    OrthoDBi EOG7D2FD7.

    Miscellaneous databases

    NextBioi 19977879.

    Family and domain databases

    InterProi IPR021063. NEMO_N.
    [Graphical view ]
    Pfami PF11577. NEMO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure of optineurin (OPTN) in Rhesus monkey."
      Rezaie T., Sarfarazi M.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiOPTN_MACMU
    AccessioniPrimary (citable) accession number: Q861Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3