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Q86195

- VP2_ROTGA

UniProt

Q86195 - VP2_ROTGA

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Protein
Inner capsid protein VP2
Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifieri10942 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 933933Inner capsid protein VP2
PRO_0000369832Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1. Interacts with VP3. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni407 – 42721Hydrophobic
Add
BLAST

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Sequencei

Sequence statusi: Complete.

Q86195-1 [UniParc]FASTAAdd to Basket

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MDSTVLVESA KTNIHGVDSK AEKQTIFDQL ISDIKSQTDG QIPDEVLPDL    50
QQLAEINGLT FEYKPKEKLS IMDHPDPTSV LSQDVFQIRT ILSKTLFVDV 100
ENEDYSVYIP NDTAKLTPVL IDARPIQTYQ PKALMHKDTA ILPSHRDEIS 150
DQYGTDEILF DSHMFNDISQ AQIRDFDTYI LDKSIQIQNT LPNLEFISSL 200
EKEVNPFNIH NTLCLNFGQK EYYNIIADRT NLSFQQRRQS VQFDNVIVDG 250
VARTARVSLR LHPFDSQLLD IVRFNVIQDQ PLADTLMEYQ LVAADGFVAT 300
PKFRVDRDAR LIADVRSPVM ARLCELSPFF HRTRILSSMT DFTPLWKVNV 350
FSSSIDNAKD AIYRMAEISF TVADATTSAL ASVNVASAQQ TLLTLLNLSL 400
FRFEIDPTGS QSNFGSAVSA ALMLIVFPTD EQSMSNITFD NLCNLVFNEL 450
IAWTVDRPTF VKRTGMTNAF EANVNIGGGN MTRDIIAYMR FVLLRRPWAV 500
FQRTYDDRYV SDIMVPNIDE ANVNDQCYVA INNLFNGLIQ AAQRNPNPGR 550
QIAATSFRKL LKSMKDSCCN RIIPLIRLLK YNIERIARVY RFFPYTADLV 600
HVIPAFRDER LRVKVPVSGM LSIALGINKA PDSFDWYNLL KFADVVRTKN 650
FADQSLESIM VHALIRNDIN PARSKKDYIQ QNIKPATNVV ASLSKLPSAT 700
FTTILADRML NNEIRRTQSY VVTNRIRDAV RAAFEHVPTA EHGIAKGALL 750
LPIPQNFQRS SVYVRKDNIL YDPPVGVDRF NLSDLLDGRF YQGLINRVQN 800
MAPFVISGPL QVKPSDASAI ESVTSAYLTM SSPYDACVRP EDLRHNRVVH 850
PPTVDYFSDA SITRPNTQFE QLMSKTSVFV IDAPRLIVQN DATVYTFDYK 900
DIQLTTSVVD KLEFTSVKTP DVTLFNGMLV YED 933
Length:933
Mass (Da):105,635
Last modified:November 1, 1996 - v1
Checksum:i3FCF4CE129F14341
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91433 Genomic RNA. Translation: AAA47350.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91433 Genomic RNA. Translation: AAA47350.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Cloning sequencing and expression of the gene encoding the VP2 protein of the human group B rotavirus, ADRV."
    Mackow E.R., Fay M.E., Shaw R., Tao H., Chen G.
    Virology 201:162-168(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTGA
AccessioniPrimary (citable) accession number: Q86195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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