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Q86195

- VP2_ROTGA

UniProt

Q86195 - VP2_ROTGA

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifieri10942 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion Curated
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).By similarity

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 933933Inner capsid protein VP2PRO_0000369832Add
BLAST

Interactioni

Subunit structurei

Dimer (Potential). Interacts with VP1. Interacts with VP3. Interacts with NSP5 (By similarity).By similarityCurated

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni407 – 42721HydrophobicAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus VP2 family.Curated

Sequencei

Sequence statusi: Complete.

Q86195-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDSTVLVESA KTNIHGVDSK AEKQTIFDQL ISDIKSQTDG QIPDEVLPDL
60 70 80 90 100
QQLAEINGLT FEYKPKEKLS IMDHPDPTSV LSQDVFQIRT ILSKTLFVDV
110 120 130 140 150
ENEDYSVYIP NDTAKLTPVL IDARPIQTYQ PKALMHKDTA ILPSHRDEIS
160 170 180 190 200
DQYGTDEILF DSHMFNDISQ AQIRDFDTYI LDKSIQIQNT LPNLEFISSL
210 220 230 240 250
EKEVNPFNIH NTLCLNFGQK EYYNIIADRT NLSFQQRRQS VQFDNVIVDG
260 270 280 290 300
VARTARVSLR LHPFDSQLLD IVRFNVIQDQ PLADTLMEYQ LVAADGFVAT
310 320 330 340 350
PKFRVDRDAR LIADVRSPVM ARLCELSPFF HRTRILSSMT DFTPLWKVNV
360 370 380 390 400
FSSSIDNAKD AIYRMAEISF TVADATTSAL ASVNVASAQQ TLLTLLNLSL
410 420 430 440 450
FRFEIDPTGS QSNFGSAVSA ALMLIVFPTD EQSMSNITFD NLCNLVFNEL
460 470 480 490 500
IAWTVDRPTF VKRTGMTNAF EANVNIGGGN MTRDIIAYMR FVLLRRPWAV
510 520 530 540 550
FQRTYDDRYV SDIMVPNIDE ANVNDQCYVA INNLFNGLIQ AAQRNPNPGR
560 570 580 590 600
QIAATSFRKL LKSMKDSCCN RIIPLIRLLK YNIERIARVY RFFPYTADLV
610 620 630 640 650
HVIPAFRDER LRVKVPVSGM LSIALGINKA PDSFDWYNLL KFADVVRTKN
660 670 680 690 700
FADQSLESIM VHALIRNDIN PARSKKDYIQ QNIKPATNVV ASLSKLPSAT
710 720 730 740 750
FTTILADRML NNEIRRTQSY VVTNRIRDAV RAAFEHVPTA EHGIAKGALL
760 770 780 790 800
LPIPQNFQRS SVYVRKDNIL YDPPVGVDRF NLSDLLDGRF YQGLINRVQN
810 820 830 840 850
MAPFVISGPL QVKPSDASAI ESVTSAYLTM SSPYDACVRP EDLRHNRVVH
860 870 880 890 900
PPTVDYFSDA SITRPNTQFE QLMSKTSVFV IDAPRLIVQN DATVYTFDYK
910 920 930
DIQLTTSVVD KLEFTSVKTP DVTLFNGMLV YED
Length:933
Mass (Da):105,635
Last modified:November 1, 1996 - v1
Checksum:i3FCF4CE129F14341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91433 Genomic RNA. Translation: AAA47350.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91433 Genomic RNA. Translation: AAA47350.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Cloning sequencing and expression of the gene encoding the VP2 protein of the human group B rotavirus, ADRV."
    Mackow E.R., Fay M.E., Shaw R., Tao H., Chen G.
    Virology 201:162-168(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTGA
AccessioniPrimary (citable) accession number: Q86195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3