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Q86195

- VP2_ROTGA

UniProt

Q86195 - VP2_ROTGA

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
    Taxonomic identifieri10942 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.By similarity

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 933933Inner capsid protein VP2PRO_0000369832Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1. Interacts with VP3. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni407 – 42721HydrophobicAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Sequencei

    Sequence statusi: Complete.

    Q86195-1 [UniParc]FASTAAdd to Basket

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    MDSTVLVESA KTNIHGVDSK AEKQTIFDQL ISDIKSQTDG QIPDEVLPDL    50
    QQLAEINGLT FEYKPKEKLS IMDHPDPTSV LSQDVFQIRT ILSKTLFVDV 100
    ENEDYSVYIP NDTAKLTPVL IDARPIQTYQ PKALMHKDTA ILPSHRDEIS 150
    DQYGTDEILF DSHMFNDISQ AQIRDFDTYI LDKSIQIQNT LPNLEFISSL 200
    EKEVNPFNIH NTLCLNFGQK EYYNIIADRT NLSFQQRRQS VQFDNVIVDG 250
    VARTARVSLR LHPFDSQLLD IVRFNVIQDQ PLADTLMEYQ LVAADGFVAT 300
    PKFRVDRDAR LIADVRSPVM ARLCELSPFF HRTRILSSMT DFTPLWKVNV 350
    FSSSIDNAKD AIYRMAEISF TVADATTSAL ASVNVASAQQ TLLTLLNLSL 400
    FRFEIDPTGS QSNFGSAVSA ALMLIVFPTD EQSMSNITFD NLCNLVFNEL 450
    IAWTVDRPTF VKRTGMTNAF EANVNIGGGN MTRDIIAYMR FVLLRRPWAV 500
    FQRTYDDRYV SDIMVPNIDE ANVNDQCYVA INNLFNGLIQ AAQRNPNPGR 550
    QIAATSFRKL LKSMKDSCCN RIIPLIRLLK YNIERIARVY RFFPYTADLV 600
    HVIPAFRDER LRVKVPVSGM LSIALGINKA PDSFDWYNLL KFADVVRTKN 650
    FADQSLESIM VHALIRNDIN PARSKKDYIQ QNIKPATNVV ASLSKLPSAT 700
    FTTILADRML NNEIRRTQSY VVTNRIRDAV RAAFEHVPTA EHGIAKGALL 750
    LPIPQNFQRS SVYVRKDNIL YDPPVGVDRF NLSDLLDGRF YQGLINRVQN 800
    MAPFVISGPL QVKPSDASAI ESVTSAYLTM SSPYDACVRP EDLRHNRVVH 850
    PPTVDYFSDA SITRPNTQFE QLMSKTSVFV IDAPRLIVQN DATVYTFDYK 900
    DIQLTTSVVD KLEFTSVKTP DVTLFNGMLV YED 933
    Length:933
    Mass (Da):105,635
    Last modified:November 1, 1996 - v1
    Checksum:i3FCF4CE129F14341
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91433 Genomic RNA. Translation: AAA47350.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91433 Genomic RNA. Translation: AAA47350.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning sequencing and expression of the gene encoding the VP2 protein of the human group B rotavirus, ADRV."
      Mackow E.R., Fay M.E., Shaw R., Tao H., Chen G.
      Virology 201:162-168(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTGA
    AccessioniPrimary (citable) accession number: Q86195
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3