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Q86194 (NSP1_ROTH3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (strain Human/Japan/AU-1/1982 G3-P3[9]-I3-R3-C3-M3-A3-N3-T3-E3-H3) (RV-A) [Complete proteome]
Taxonomic identifier39013 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Non-structural protein 1
PRO_0000369082

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region316 – 491176Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q86194 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 160FFA3487C37D7C

FASTA49158,653
        10         20         30         40         50         60 
MATFKDACYH YRRLNKLNNL VLKLGANDEW RPAPVTKYKG WCLDCCQHTN LTYCRGCALY 

        70         80         90        100        110        120 
HVCQWCSQYN RCFLDEEPHL LRMRTFKNVM TKEDIEGLLT MYETLFPINE KLVNKFTDFV 

       130        140        150        160        170        180 
KQRKCRNEYL LEWYNHLLMP ITLQALTVKL EDNIYYICGY YDCMEHENQT PLQFINLLEK 

       190        200        210        220        230        240 
YDKLLLDDRN FNRMSYLPTI LQQEYALRYF SKSRFFSKKE KRLSRNDFSD NLMEDRHSPI 

       250        260        270        280        290        300 
SLIQVIRNCI STHMNDSEWN KACTLVVDPK NYIDIINSSY TEHYSVSQRC KLFTKYKLGI 

       310        320        330        340        350        360 
VSKLVRPNYI FSSHESCALN VHNCKWCQTN NHYKVWADFR LKKIYNNMMD FVRALTKSNG 

       370        380        390        400        410        420 
NVGHCSSQES ESKCIPDIFL ICEMEKWNGP VRVLFRYLEP VDINGEEYVL LDYEVNWEVR 

       430        440        450        460        470        480 
GLIIQNMDGR VPRILNMDDV KKILSAIIFD WFDVRYMRET PLTTLTTNQL RALNRKNELI 

       490 
DEYDLELSDV E 

« Hide

References

[1]"Distinctness of NSP1 gene of human rotavirus AU-1 from NSP1 gene of other human genogroups."
Nakagomi O., Kaga E.
Res. Virol. 146:423-428(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D45244 mRNA. Translation: BAA08200.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTH3
AccessionPrimary (citable) accession number: Q86194
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families