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Q86119

- POLG_RHDVA

UniProt

Q86119 - POLG_RHDVA

Protein

Genome polyprotein

Gene

ORF1

Organism
Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    NTPase presumably plays a role in replication.By similarity
    Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation By similarity.By similarity
    3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved.By similarity
    RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs By similarity.PROSITE-ProRule annotation
    Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.By similarity

    Catalytic activityi

    NTP + H2O = NDP + phosphate.
    Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.
    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei143 – 1442Cleavage; by 3CLproBy similarity
    Sitei339 – 3402Cleavage; by 3CLproBy similarity
    Sitei718 – 7192Cleavage; by 3CLproBy similarity
    Sitei936 – 9372Cleavage; by hostBy similarity
    Sitei993 – 9942Cleavage; by 3CLproBy similarity
    Sitei1108 – 11092Cleavage; by 3CLproBy similarity
    Active sitei1135 – 11351For 3CLpro activityBy similarity
    Active sitei1159 – 11591For 3CLpro activityBy similarity
    Active sitei1212 – 12121For 3CLpro activitySequence Analysis
    Sitei1251 – 12522Cleavage; by 3CLproBy similarity
    Sitei1767 – 17682Cleavage; by 3CLproBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi522 – 5298ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cysteine-type endopeptidase activity Source: InterPro
    3. RNA binding Source: InterPro
    4. RNA-directed RNA polymerase activity Source: UniProtKB-KW
    5. RNA helicase activity Source: InterPro

    GO - Biological processi

    1. RNA-protein covalent cross-linking Source: UniProtKB-KW
    2. transcription, DNA-templated Source: InterPro
    3. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Helicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Genome polyprotein
    Alternative name(s):
    p254
    Cleaved into the following 11 chains:
    Alternative name(s):
    2C-like protein
    P2C
    p37
    Alternative name(s):
    VPg
    p13
    3C-like protease (EC:3.4.22.66)
    Short name:
    3CLpro
    Alternative name(s):
    Calicivirin
    Thiol protease P3C
    p15
    Alternative name(s):
    3Dpol
    p58
    Gene namesi
    ORF Names:ORF1
    OrganismiRabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)
    Taxonomic identifieri314538 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
    Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]
    ProteomesiUP000008653: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host cytoplasm, Virion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1767 – 17671E → G: Loss of cleavage between RNA-directed RNA polymerase and VP60. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23442344Genome polyproteinPRO_0000341999Add
    BLAST
    Chaini1 – 143143Protein p16By similarityPRO_0000036941Add
    BLAST
    Chaini144 – 339196Protein p23By similarityPRO_0000036942Add
    BLAST
    Chaini340 – 718379NTPaseBy similarityPRO_0000036943Add
    BLAST
    Chaini712 – 1108397Precursor p41By similarityPRO_0000342000Add
    BLAST
    Chaini712 – 936225Protein p23/2By similarityPRO_0000342001Add
    BLAST
    Chaini719 – 993275Protein p29By similarityPRO_0000036944Add
    BLAST
    Chaini937 – 1108172Protein p18By similarityPRO_0000342002Add
    BLAST
    Chaini994 – 1108115Viral genome-linked proteinBy similarityPRO_0000036945Add
    BLAST
    Chaini1109 – 12511433C-like proteaseBy similarityPRO_0000036946Add
    BLAST
    Chaini1252 – 1767516RNA-directed RNA polymeraseBy similarityPRO_0000036947Add
    BLAST
    Chaini1768 – 2344577Capsid protein VP60By similarityPRO_0000036949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1014 – 10141O-(5'-phospho-RNA)-tyrosine
    Modified residuei1014 – 10141O-UMP-tyrosine; transient1 Publication
    Disulfide bondi1584 ↔ 1591By similarity

    Post-translational modificationi

    Specific enzymatic cleavages by its own cysteine protease yield mature proteins. The protease cleaves itself from the nascent polyprotein autocatalytically. Precursor p41 can be cleaved by viral 3CLpro into protein p19 and VPg, or cleaved by host protease into protein p23/2 and protein p18 By similarity.By similarity
    VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the polyadenylated genomic and subgenomic RNAs. This uridylylated form acts as a nucleotide-peptide primer for the polymerase.

    Keywords - PTMi

    Covalent protein-RNA linkage, Disulfide bond, Phosphoprotein

    Interactioni

    Subunit structurei

    Binds to histo-blood group antigens at surface of target cells.By similarity

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZUEelectron microscopy10.30A/B/C1766-2344[»]
    ProteinModelPortaliQ86119.
    SMRiQ86119. Positions 1256-1752.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini492 – 653162SF3 helicasePROSITE-ProRule annotationAdd
    BLAST
    Domaini1120 – 121899Peptidase C24Add
    BLAST
    Domaini1495 – 1619125RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 peptidase C24 domain.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation
    Contains 1 SF3 helicase domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.60.120.20. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR004005. Calicivirus_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000317. Peptidase_C24.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00915. Calici_coat. 1 hit.
    PF03510. Peptidase_C24. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00910. RNA_helicase. 1 hit.
    [Graphical view]
    PRINTSiPR00916. 2CENDOPTASE.
    PR00918. CALICVIRUSNS.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform Genome polyprotein (identifier: Q86119-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAMSRLTGM TTAILPEKKP LNFFLDLRDK TPPCCIRATG KLAWPVFLGQ     50
    NGKEGPLETC NKCGKWLNGF GCFGLEDLGD VCLCSIAQQK HKFGPVCLCN 100
    RAYIHDCGRW RRRSRFLKHY KALNKVIPCA YQFDESFSTP VFEGEVDDLF 150
    VELGAPTSMG FMDKKLLKKG KKLMDKFVDV DEPCLTSRDA SLLDSIASDN 200
    TIRAKLEEEY GVEMVQAARD RKDFMKNLRL ALDNRPANPV TWYTKLGNIT 250
    EKGKQWAKKV VYGACKVTDP LKTLASILLV GLHNVIAVDT TVMLSTFKPV 300
    NLLAILMDWT NDLTGFVTTL VRLLELYGVV QATVNLIVEG VKSFWDKVVC 350
    ATDRCFDLLK RLFDTFEDSV PTGPTAGCLI FMAFVFSTVV GYLPNNSVIT 400
    TFMKGAGKLT TFAGVIGAIR TLWITINQHM VAKDLTSIQQ KVMTVVKMAN 450
    EAATLDQLEI VSCLCSDLEN TLTNRCTLPS YNQHLGILNA SQKVISDLHT 500
    MVLGKINMTK QRPQPVAVIF KGAPGIGKTY LVHRIARDLG CQHPSTINFG 550
    LDHFDSYTGE EVAIADEFNT CGDGESWVEL FIQMVNTNPC PLNCDKAENK 600
    NKVFNSKYLL CTTNSNMILN ATHPRAGAFY RRVMIVEARN KAVESWQATR 650
    HGSKPGRSCY SKDMSHLTFQ VYPHNMPAPG FVFVGDKLVK SQVAPREYKY 700
    SELLDLIKSE HPDVASFEGA NRFNFVYPDA QYDQALLMWK QYFVMYGCVA 750
    RLAKNFVDDI PYNQVHISRA SDPKIEGCVE YQCKFQHLWR MVPQFVLGCV 800
    NMTNQLGTPL TQQQLDRITN GVEGVTVTTV NNILPFHSQT TLINPSFIKL 850
    IWAVRKHLKG LSGVTKVAQF IWRVMTNPVD AYGSLVRTLT GAATFSDDPV 900
    STTIICSNCT IQIHSCGGLL VRYSRDPVPV ASDNVDRGDQ GVDVFTDPNL 950
    ISGFSWRQIA HLFVEVISHL CANHLVNLAT MAALGAVATK AFQGVKGKTK 1000
    RGRGARVNLG NDEYDEWQAA RREFVNAHDM TAEEYLAMKN KAAMGSDDQD 1050
    SVMFRSWWTR RQLRPDEDQV TVVGRGGVRN EVIRTRVRQT PKGPKTLDDG 1100
    GFYDNDYEGL PGFMRHNGSG WMIHIGNGLY ISNTHTARSS CSEVVTCSPT 1150
    TDLCLVKGEA IRSVAQIAEG TPVCDWKKSP ISTYGIKKTL SDSTKIDVLA 1200
    YDGCTQTTHG DCGLPLYDSS GKIVAIHTGK LLGFSKMCTL IDLTITKGVY 1250
    ETSNFFCGEP IDYRGITAHR LVGAEPRPPV SGTRYAKVPG VPEEYKTGYR 1300
    PANLGRSDPD SDKSLMNIAV KNLQVYQQEP KLDKVDEFIE RAAADVLGYL 1350
    RFLTKGERQA NLNFKAAFNT LDLSTSCGPF VPGKKIDHVK DGVMDQVHAK 1400
    HLYKCWSVAN SGKALHHIYA CGLKDELRPL DKVKEGKKRL LWGCDVGVAV 1450
    CAAAVFHNIC YKLKMVARFG PIAVGVDMTS RDVDVIINNL TSKASDFLCL 1500
    DYSKWDSTMS PCVVRLAIDI LADCCEQTEL TKSVVLTLKS HPMTILDAMI 1550
    VQTKRGLPSG MPFTSVINSI CHWLLWSAAV YKSCAEIGLH CSNLYEDAPF 1600
    YTYGDDGVYA MTPMMVSLLP AIIENLRDYG LSPTAADKTE FIDVCPLNKI 1650
    SFLKRTFELT DIGWVSKLDK SSILRQLEWS KTTSRHMMIE ETYDLAKEER 1700
    GVQLEELQVA AAAHGQEFFN FVCKELERQQ AYTQFSVYSY DAARKILADR 1750
    KRVVSVVPDD EFVNVMEGKA RTAPQGEAAG TATTASVPGT TTDGMDPGVV 1800
    ATTSVVTAEN SSASIATAGI GGPPQQVDQQ ETWRTNFYYN DVFTWSVADA 1850
    PGSILYTVQH SPQNNPFTAV LSQMYAGWAG GMQFRFIVAG SGVFGGRLVA 1900
    AVIPPGIEIG PGLEVRQFPH VVIDARSLEP VTITMPDLRP NMYHPTGDPG 1950
    LVPTLVLSVY NNLINPFGGS TSAIQVTVET RPSEDFEFVM IRAPSSKTVD 2000
    SISPAGLLTT PVLTGVGNDN RWNGQIVGLQ PVPGGFSTCN RHWNLNGSTY 2050
    GWSSPRFADI DHRRGSASYP GNNATNVLQF WYANAGSAID NPISQVAPDG 2100
    FPDMSFVPFN GPGIPAAGWV GFGAIWNSNS GAPNVTTVQA YELGFATGAP 2150
    GNLQPTTNTS GSQTVAKSIY AVVTGTAQNP AGLFVMASGV ISTPSANAIT 2200
    YTPQPDRIVT TPGTPAAAPV GKNTPIMFAS VVRRTGDVNA TAGSANGTQY 2250
    GTGSQPLPVT IGLSLNNYSS ALMPGQFFVW QLTFASGFME IGLSVDGYFY 2300
    AGTGASTTLI DLTELIDVRP VGPRPSKSTL VFNLGGTANG FSYV 2344

    Note: Produced from the genomic RNA.

    Length:2,344
    Mass (Da):256,817
    Last modified:October 1, 2003 - v2
    Checksum:iE1C61F038111F092
    GO
    Isoform Subgenomic capsid protein VP60 (identifier: Q86119-2) [UniParc]FASTAAdd to Basket

    Also known as: VP1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1765: Missing.

    Note: Produced from the subgenomic RNA.

    Show »
    Length:579
    Mass (Da):60,241
    Checksum:i7BA463B7C7D77BAC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 17651765Missing in isoform Subgenomic capsid protein VP60. CuratedVSP_034379Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49271 Genomic RNA. Translation: CAA89265.2.
    Z49271 Genomic RNA. Translation: CAD91718.1.
    Z24757 Genomic RNA. Translation: CAA80881.1. Sequence problems.
    Z24757 Genomic RNA. Translation: CAA80883.1. Sequence problems.
    X73046 mRNA. Translation: CAA51524.1.
    PIRiS64740.

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49271 Genomic RNA. Translation: CAA89265.2 .
    Z49271 Genomic RNA. Translation: CAD91718.1 .
    Z24757 Genomic RNA. Translation: CAA80881.1 . Sequence problems.
    Z24757 Genomic RNA. Translation: CAA80883.1 . Sequence problems.
    X73046 mRNA. Translation: CAA51524.1 .
    PIRi S64740.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZUE electron microscopy 10.30 A/B/C 1766-2344 [» ]
    ProteinModelPortali Q86119.
    SMRi Q86119. Positions 1256-1752.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.20. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR004005. Calicivirus_coat.
    IPR004004. Helic/Pol/Pept_Calicivir-typ.
    IPR000605. Helicase_SF3_ssDNA/RNA_vir.
    IPR014759. Helicase_SF3_ssRNA_vir.
    IPR027417. P-loop_NTPase.
    IPR000317. Peptidase_C24.
    IPR001205. RNA-dir_pol_C.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR009003. Trypsin-like_Pept_dom.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00915. Calici_coat. 1 hit.
    PF03510. Peptidase_C24. 1 hit.
    PF00680. RdRP_1. 1 hit.
    PF00910. RNA_helicase. 1 hit.
    [Graphical view ]
    PRINTSi PR00916. 2CENDOPTASE.
    PR00918. CALICVIRUSNS.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51218. SF3_HELICASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Processing of rabbit hemorrhagic disease virus polyprotein."
      Martin-Alonso J.M., Casais R., Boga J.A., Parra F.
      J. Virol. 70:1261-1265(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 719-724 AND 1009-1114, MUTAGENESIS OF GLU-1767, PROTEOLYTIC PROCESSING OF POLYPROTEIN.
    2. Casais R., Martin-Alonso J.M., Boga J.A., Parra F.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 1891; 2058 AND 2061.
    3. "Molecular cloning, sequence and expression of the capsid protein gene from rabbit hemorrhagic disease virus (Spanish isolate AST/89)."
      Boga J.A., Casais R., Marin M.S., Martin-Alonso J.M., Carmenes R., Prieto M., Parra F.
      J. Gen. Virol. 75:2409-2413(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1650-2344.
    4. "The amino terminal sequence of VP60 from rabbit hemorrhagic disease virus supports its putative subgenomic origin."
      Parra F., Boga J.A., Marin M.S., Casais R.
      Virus Res. 27:219-228(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1766-1797, PROTEIN SEQUENCE OF 1767-1780.
    5. "In vitro translation of a subgenomic mRNA from purified virions of the Spanish field isolate AST/89 of rabbit hemorrhagic disease virus (RHDV)."
      Boga J.A., Marin M.S., Casais R., Prieto M., Parra F.
      Virus Res. 26:33-40(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBGENOMIC ORIGIN OF VP60.
    6. "Identification of the amino acid residue involved in rabbit hemorrhagic disease virus VPg uridylylation."
      Machin A., Martin Alonso J.M., Parra F.
      J. Biol. Chem. 276:27787-27792(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: COVALENT RNA-LINKAGE AT TYR-1014 OF VPG, URIDYLYLATION AT TYR-1014.
    7. "Synthesis in vitro of rabbit hemorrhagic disease virus subgenomic RNA by internal initiation on (-)sense genomic RNA: mapping of a subgenomic promoter."
      Morales M., Barcena J., Ramirez M.A., Boga J.A., Parra F., Torres J.M.
      J. Biol. Chem. 279:17013-17018(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBGENOMIC ORIGIN OF VP60.
    8. "NMR experiments reveal the molecular basis of receptor recognition by a calicivirus."
      Rademacher C., Krishna N.R., Palcic M., Parra F., Peters T.
      J. Am. Chem. Soc. 130:3669-3675(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION OF VP60 WITH HISTO-BLOOD GROUP ANTIGENS.

    Entry informationi

    Entry nameiPOLG_RHDVA
    AccessioniPrimary (citable) accession number: Q86119
    Secondary accession number(s): Q7THT7
    , Q86123, Q86124, Q9IBM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Two differents RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3