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Q86108

- VP2_ROTGI

UniProt

Q86108 - VP2_ROTGI

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
    Taxonomic identifieri28877 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Rattus norvegicus (Rat) [TaxID: 10116]

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.By similarity

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 934934Inner capsid protein VP2PRO_0000369833Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1. Interacts with VP3. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni407 – 42721HydrophobicAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Sequencei

    Sequence statusi: Complete.

    Q86108-1 [UniParc]FASTAAdd to Basket

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    MDFPNLVLSA KNSIQNVDSK DEKQKIIDQL ISDIRGQNDG VIPDEVLSEI    50
    QQVAEINGLS FNYEKPVKQE LLEQPDPTSV LSQEVFQIRT ILSKTLFVDV 100
    EAEDYSVYIP DETSNLSPVQ IDARPIQTYQ PKALMYKDTA ILPSNRDEVS 150
    DQYGADEILF DSHMFNDISQ AQIRDFETYV LDKAMQIQSS LPNLDFVSSL 200
    DKEVNPFNVH NTLCLNFGQR EYYNIIADRT NQSFQQRRQS VQFDNVVVDG 250
    VARRARVSLR LHPFDSQLLD IIRFNTIQDQ PLADTMAEYQ LVAADGFVAT 300
    PRFRTDRDAR LIADVRSRVM ARLCELSPYF HRTRILSSMT DFNSLWKVNV 350
    FSSSIDNAKD AIYRMAEISF TVADATTSAL SSVNIASAQQ TLLVLLNMSL 400
    FRFEIEPVGS QSNFGAAVSA ALMLVVFPTD EASMSNVTFD NLCNLVFNEL 450
    IAWTVDRPTF VKRTGMTNAF EANVNIGGGN MTRDITAYMR FVLLRRPWAV 500
    FQRTYDDQYV ADIMVPNIDE ANVNDQSYMA INNLFSGLIQ AAQRNPNPGR 550
    QIAATSFRKL LKSMKDSCCN RIMPLIRLMK YNVERIARIY RFFPYTADLV 600
    QRIPAFRDER IRIKVPVSGM LSIALGINKS PDVFDWYNLL RFADVIRTKN 650
    FAERQSLESI MVQALIRNDI NPARSRKEYI QQNIKPATNV VASITKVPSA 700
    TFTTILSDRM LNNEIRRTQS YIVVNRIRDA VRAAFEHVPT AEHGIAKGAL 750
    LLPYPQNFQR SSVYVRKDNI LYNAPVGVDR FSLDDLLNGR FYQGMVNRIQ 800
    NMSPFVIAGP LQVRASNASA IDSVTSAYLT MSSPYDACVK PEDLRHNRIV 850
    QPPIVDFFSD SSITRPNTQF EQLMSKTSVF VIDAPKLIVQ SDATVYNFDY 900
    RDIQLTTSVV DKLEFTSVKT PDVTLFNGML VFED 934
    Length:934
    Mass (Da):106,015
    Last modified:November 1, 1996 - v1
    Checksum:iF61A623E0B4CA090
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00673 Genomic RNA. Translation: AAA17401.1.
    PIRiA49808.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00673 Genomic RNA. Translation: AAA17401.1 .
    PIRi A49808.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Group B rotavirus VP2: sequence analysis, expression, and gene coding assignment."
      Lindsay D.A., Waggie K.S., Eiden J.J.
      Virology 199:141-150(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTGI
    AccessioniPrimary (citable) accession number: Q86108
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3