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Q86108

- VP2_ROTGI

UniProt

Q86108 - VP2_ROTGI

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus B (isolate Rat/United States/IDIR/1984) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
Taxonomic identifieri28877 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 934934Inner capsid protein VP2PRO_0000369833Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1. Interacts with VP3. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni407 – 42721HydrophobicAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Sequencei

Sequence statusi: Complete.

Q86108-1 [UniParc]FASTAAdd to Basket

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MDFPNLVLSA KNSIQNVDSK DEKQKIIDQL ISDIRGQNDG VIPDEVLSEI    50
QQVAEINGLS FNYEKPVKQE LLEQPDPTSV LSQEVFQIRT ILSKTLFVDV 100
EAEDYSVYIP DETSNLSPVQ IDARPIQTYQ PKALMYKDTA ILPSNRDEVS 150
DQYGADEILF DSHMFNDISQ AQIRDFETYV LDKAMQIQSS LPNLDFVSSL 200
DKEVNPFNVH NTLCLNFGQR EYYNIIADRT NQSFQQRRQS VQFDNVVVDG 250
VARRARVSLR LHPFDSQLLD IIRFNTIQDQ PLADTMAEYQ LVAADGFVAT 300
PRFRTDRDAR LIADVRSRVM ARLCELSPYF HRTRILSSMT DFNSLWKVNV 350
FSSSIDNAKD AIYRMAEISF TVADATTSAL SSVNIASAQQ TLLVLLNMSL 400
FRFEIEPVGS QSNFGAAVSA ALMLVVFPTD EASMSNVTFD NLCNLVFNEL 450
IAWTVDRPTF VKRTGMTNAF EANVNIGGGN MTRDITAYMR FVLLRRPWAV 500
FQRTYDDQYV ADIMVPNIDE ANVNDQSYMA INNLFSGLIQ AAQRNPNPGR 550
QIAATSFRKL LKSMKDSCCN RIMPLIRLMK YNVERIARIY RFFPYTADLV 600
QRIPAFRDER IRIKVPVSGM LSIALGINKS PDVFDWYNLL RFADVIRTKN 650
FAERQSLESI MVQALIRNDI NPARSRKEYI QQNIKPATNV VASITKVPSA 700
TFTTILSDRM LNNEIRRTQS YIVVNRIRDA VRAAFEHVPT AEHGIAKGAL 750
LLPYPQNFQR SSVYVRKDNI LYNAPVGVDR FSLDDLLNGR FYQGMVNRIQ 800
NMSPFVIAGP LQVRASNASA IDSVTSAYLT MSSPYDACVK PEDLRHNRIV 850
QPPIVDFFSD SSITRPNTQF EQLMSKTSVF VIDAPKLIVQ SDATVYNFDY 900
RDIQLTTSVV DKLEFTSVKT PDVTLFNGML VFED 934
Length:934
Mass (Da):106,015
Last modified:November 1, 1996 - v1
Checksum:iF61A623E0B4CA090
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00673 Genomic RNA. Translation: AAA17401.1.
PIRiA49808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00673 Genomic RNA. Translation: AAA17401.1 .
PIRi A49808.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Group B rotavirus VP2: sequence analysis, expression, and gene coding assignment."
    Lindsay D.A., Waggie K.S., Eiden J.J.
    Virology 199:141-150(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTGI
AccessioniPrimary (citable) accession number: Q86108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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