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Q85QA3

- COX1_CANGA

UniProt

Q85QA3 - COX1_CANGA

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621Iron (heme A axial ligand)By similarity
    Metal bindingi241 – 2411Copper BBy similarity
    Metal bindingi245 – 2451Copper BBy similarity
    Metal bindingi290 – 2901Copper BBy similarity
    Metal bindingi291 – 2911Copper BBy similarity
    Metal bindingi376 – 3761Iron (heme A3 axial ligand)By similarity
    Metal bindingi378 – 3781Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. endonuclease activity Source: CGD
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. hydrogen ion transmembrane transport Source: GOC
    3. mitochondrial electron transport, cytochrome c to oxygen Source: CGD
    4. movement of group I intron Source: CGD
    5. nucleic acid phosphodiester bond hydrolysis Source: GOC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Encoded oniMitochondrion
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: CGD
    3. mitochondrion Source: CGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534Cytochrome c oxidase subunit 1PRO_0000183300Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ85QA3.
    SMRiQ85QA3. Positions 2-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 21123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 36023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei375 – 39723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 47323HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000085274.
    KOiK02256.
    OrthoDBiEOG72C58S.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q85QA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQRWLYSTN AKDIAVLYFM IALFSGMAGT AMSMIIRLEL AAPGSQYLAG    50
    NNQLFNVLVV GHAVLMIFFL VMPALIGGFG NYMLPLMIGA SDMAFPRLNN 100
    VGFWLIVPAL VCLVTSTLVE AGAGTGWTVY PPLSSIQAHS GPSVDLAIFA 150
    LHLTSISSLL GSINFIVTTL NMRTNGMTMH KLPLFVWAIF ITAFLLLLSL 200
    PVLSAGVTML LLDRNFNTSF FEVAGGGDPI LYQHLFWFFG HPEVYILIIP 250
    GFGIISHIVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD 300
    TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLAVPMLY AIAFLFLFTI 350
    GGMTGVALAN ASLDVAFHDT YYVVGHFHYV LSMGAVFSTI AGYYYWSPQI 400
    LGLYYNEKLA QIQFWLIFVG ANVTFMPMHF LGINGMPRRI PDYPDAFAGW 450
    NYVASVGSFI AMISLVLFIY ILYDQFVNGL TNKANNKSVL YTKSPDFVES 500
    NEIFNLNTIK TSSIEFLLTS PPAVHSFNTP AVQS 534
    Length:534
    Mass (Da):58,737
    Last modified:June 1, 2003 - v1
    Checksum:iDE47C9A2F2D513DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ511533 Genomic DNA. Translation: CAD54419.1.
    RefSeqiNP_818778.1. NC_004691.1.

    Genome annotation databases

    GeneIDi807004.
    KEGGicgr:CaglfMp04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ511533 Genomic DNA. Translation: CAD54419.1 .
    RefSeqi NP_818778.1. NC_004691.1.

    3D structure databases

    ProteinModelPortali Q85QA3.
    SMRi Q85QA3. Positions 2-532.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 807004.
    KEGGi cgr:CaglfMp04.

    Phylogenomic databases

    HOGENOMi HOG000085274.
    KOi K02256.
    OrthoDBi EOG72C58S.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete mitochondrial genome sequence of the pathogenic yeast Candida (Torulopsis) glabrata."
      Koszul R., Malpertuy A., Frangeul L., Bouchier C., Wincker P., Thierry A., Duthoy S., Ferris S., Hennequin C., Dujon B.
      FEBS Lett. 534:39-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

    Entry informationi

    Entry nameiCOX1_CANGA
    AccessioniPrimary (citable) accession number: Q85QA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3