Cytochrome c oxidase subunit 1 - Candida glabrata (Yeast)

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Reviewed, UniProtKB/Swiss-Prot Q85QA3 (COX1_CANGA)

Last modified October 13, 2009. Version 35. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I

Gene names

Name:

COX1

Encoded on

Mitochondrion

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

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Protein attributes

Sequence length	534 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

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Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 534

534

Cytochrome c oxidase subunit 1

PRO_0000183300

Regions

Transmembrane

14 – 36

Potential

Transmembrane

57 – 79

Potential

Transmembrane

146 – 168

Potential

Transmembrane

189 – 211

Potential

Transmembrane

237 – 259

Potential

Transmembrane

266 – 288

Potential

Transmembrane

303 – 325

Potential

Transmembrane

338 – 360

Potential

Transmembrane

375 – 397

Potential

Transmembrane

414 – 436

Potential

Transmembrane

451 – 473

Potential

Sites

Metal binding

Iron (heme A axial ligand) By similarity

Metal binding

241

Copper B By similarity

Metal binding

245

Copper B By similarity

Metal binding

290

Copper B By similarity

Metal binding

291

Copper B By similarity

Metal binding

376

Iron (heme A3 axial ligand) By similarity

Metal binding

378

Iron (heme A axial ligand) By similarity

Amino acid modifications

Cross-link

241 ↔ 245

1'-histidyl-3'-tyrosine (His-Tyr) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q85QA3-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: DE47C9A2F2D513DF
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FASTA

534

58,737

        10         20         30         40         50         60 
MVQRWLYSTN AKDIAVLYFM IALFSGMAGT AMSMIIRLEL AAPGSQYLAG NNQLFNVLVV 

        70         80         90        100        110        120 
GHAVLMIFFL VMPALIGGFG NYMLPLMIGA SDMAFPRLNN VGFWLIVPAL VCLVTSTLVE 

       130        140        150        160        170        180 
AGAGTGWTVY PPLSSIQAHS GPSVDLAIFA LHLTSISSLL GSINFIVTTL NMRTNGMTMH 

       190        200        210        220        230        240 
KLPLFVWAIF ITAFLLLLSL PVLSAGVTML LLDRNFNTSF FEVAGGGDPI LYQHLFWFFG 

       250        260        270        280        290        300 
HPEVYILIIP GFGIISHIVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLAVPMLY AIAFLFLFTI GGMTGVALAN 

       370        380        390        400        410        420 
ASLDVAFHDT YYVVGHFHYV LSMGAVFSTI AGYYYWSPQI LGLYYNEKLA QIQFWLIFVG 

       430        440        450        460        470        480 
ANVTFMPMHF LGINGMPRRI PDYPDAFAGW NYVASVGSFI AMISLVLFIY ILYDQFVNGL 

       490        500        510        520        530 
TNKANNKSVL YTKSPDFVES NEIFNLNTIK TSSIEFLLTS PPAVHSFNTP AVQS

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References

[1]

"The complete mitochondrial genome sequence of the pathogenic yeast Candida (Torulopsis) glabrata."
Koszul R., Malpertuy A., Frangeul L., Bouchier C., Wincker P., Thierry A., Duthoy S., Ferris S., Hennequin C., Dujon B.
FEBS Lett. 534:39-48(2003) [PubMed: 12527359] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

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Cross-references

Sequence databases
	AJ511533 Genomic DNA. Translation: CAD54419.1.
RefSeq	NP_818778.1.
3D structure databases
HSSP	HSSP built from PDB template 1M56 based on UniProtKB P33517.
ModBase	Search...
Genome annotation databases
GeneID	807004.
GenomeReviews	Gene locus COX1 in contig AJ511533_GR.
KEGG	cgr:CaglfMp04.
Enzyme and pathway databases
BRENDA	1.9.3.1. 189220.
Family and domain databases
InterPro	IPR000883. Cyt_c_oxidase_su1. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

COX1_CANGA

Accession

Primary (citable) accession number: Q85QA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	June 1, 2003
Last modified:	October 13, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents