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Q85QA3

- COX1_CANGA

UniProt

Q85QA3 - COX1_CANGA

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Protein

Cytochrome c oxidase subunit 1

Gene
COX1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron (heme A axial ligand) By similarity
Metal bindingi241 – 2411Copper B By similarity
Metal bindingi245 – 2451Copper B By similarity
Metal bindingi290 – 2901Copper B By similarity
Metal bindingi291 – 2911Copper B By similarity
Metal bindingi376 – 3761Iron (heme A3 axial ligand) By similarity
Metal bindingi378 – 3781Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. endonuclease activity Source: CGD
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, cytochrome c to oxygen Source: CGD
  4. movement of group I intron Source: CGD
  5. nucleic acid phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3623Helical; Reviewed predictionAdd
BLAST
Transmembranei57 – 7923Helical; Reviewed predictionAdd
BLAST
Transmembranei146 – 16823Helical; Reviewed predictionAdd
BLAST
Transmembranei189 – 21123Helical; Reviewed predictionAdd
BLAST
Transmembranei237 – 25923Helical; Reviewed predictionAdd
BLAST
Transmembranei266 – 28823Helical; Reviewed predictionAdd
BLAST
Transmembranei303 – 32523Helical; Reviewed predictionAdd
BLAST
Transmembranei338 – 36023Helical; Reviewed predictionAdd
BLAST
Transmembranei375 – 39723Helical; Reviewed predictionAdd
BLAST
Transmembranei414 – 43623Helical; Reviewed predictionAdd
BLAST
Transmembranei451 – 47323Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: CGD
  3. mitochondrion Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Cytochrome c oxidase subunit 1PRO_0000183300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ85QA3.
SMRiQ85QA3. Positions 2-532.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274.
KOiK02256.
OrthoDBiEOG72C58S.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q85QA3-1 [UniParc]FASTAAdd to Basket

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MVQRWLYSTN AKDIAVLYFM IALFSGMAGT AMSMIIRLEL AAPGSQYLAG    50
NNQLFNVLVV GHAVLMIFFL VMPALIGGFG NYMLPLMIGA SDMAFPRLNN 100
VGFWLIVPAL VCLVTSTLVE AGAGTGWTVY PPLSSIQAHS GPSVDLAIFA 150
LHLTSISSLL GSINFIVTTL NMRTNGMTMH KLPLFVWAIF ITAFLLLLSL 200
PVLSAGVTML LLDRNFNTSF FEVAGGGDPI LYQHLFWFFG HPEVYILIIP 250
GFGIISHIVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD 300
TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLAVPMLY AIAFLFLFTI 350
GGMTGVALAN ASLDVAFHDT YYVVGHFHYV LSMGAVFSTI AGYYYWSPQI 400
LGLYYNEKLA QIQFWLIFVG ANVTFMPMHF LGINGMPRRI PDYPDAFAGW 450
NYVASVGSFI AMISLVLFIY ILYDQFVNGL TNKANNKSVL YTKSPDFVES 500
NEIFNLNTIK TSSIEFLLTS PPAVHSFNTP AVQS 534
Length:534
Mass (Da):58,737
Last modified:June 1, 2003 - v1
Checksum:iDE47C9A2F2D513DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ511533 Genomic DNA. Translation: CAD54419.1.
RefSeqiNP_818778.1. NC_004691.1.

Genome annotation databases

GeneIDi807004.
KEGGicgr:CaglfMp04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ511533 Genomic DNA. Translation: CAD54419.1 .
RefSeqi NP_818778.1. NC_004691.1.

3D structure databases

ProteinModelPortali Q85QA3.
SMRi Q85QA3. Positions 2-532.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807004.
KEGGi cgr:CaglfMp04.

Phylogenomic databases

HOGENOMi HOG000085274.
KOi K02256.
OrthoDBi EOG72C58S.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete mitochondrial genome sequence of the pathogenic yeast Candida (Torulopsis) glabrata."
    Koszul R., Malpertuy A., Frangeul L., Bouchier C., Wincker P., Thierry A., Duthoy S., Ferris S., Hennequin C., Dujon B.
    FEBS Lett. 534:39-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiCOX1_CANGA
AccessioniPrimary (citable) accession number: Q85QA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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