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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Iron (heme A axial ligand)By similarity1
Metal bindingi241Copper BBy similarity1
Metal bindingi245Copper BBy similarity1
Metal bindingi290Copper BBy similarity1
Metal bindingi291Copper BBy similarity1
Metal bindingi376Iron (heme A3 axial ligand)By similarity1
Metal bindingi378Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Mitochondrion

Organism-specific databases

CGDiCAL0139468 COX1
EuPathDBiFungiDB:CaglfMp04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 36HelicalSequence analysisAdd BLAST23
Transmembranei57 – 79HelicalSequence analysisAdd BLAST23
Transmembranei146 – 168HelicalSequence analysisAdd BLAST23
Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
Transmembranei237 – 259HelicalSequence analysisAdd BLAST23
Transmembranei266 – 288HelicalSequence analysisAdd BLAST23
Transmembranei303 – 325HelicalSequence analysisAdd BLAST23
Transmembranei338 – 360HelicalSequence analysisAdd BLAST23
Transmembranei375 – 397HelicalSequence analysisAdd BLAST23
Transmembranei414 – 436HelicalSequence analysisAdd BLAST23
Transmembranei451 – 473HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833001 – 534Cytochrome c oxidase subunit 1Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

STRINGi284593.NP_818778.1

Structurei

3D structure databases

ProteinModelPortaliQ85QA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4769 Eukaryota
COG0843 LUCA
HOGENOMiHOG000085274
InParanoidiQ85QA3
KOiK02256
OrthoDBiEOG092C2KU4

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q85QA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRWLYSTN AKDIAVLYFM IALFSGMAGT AMSMIIRLEL AAPGSQYLAG
60 70 80 90 100
NNQLFNVLVV GHAVLMIFFL VMPALIGGFG NYMLPLMIGA SDMAFPRLNN
110 120 130 140 150
VGFWLIVPAL VCLVTSTLVE AGAGTGWTVY PPLSSIQAHS GPSVDLAIFA
160 170 180 190 200
LHLTSISSLL GSINFIVTTL NMRTNGMTMH KLPLFVWAIF ITAFLLLLSL
210 220 230 240 250
PVLSAGVTML LLDRNFNTSF FEVAGGGDPI LYQHLFWFFG HPEVYILIIP
260 270 280 290 300
GFGIISHIVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD
310 320 330 340 350
TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLAVPMLY AIAFLFLFTI
360 370 380 390 400
GGMTGVALAN ASLDVAFHDT YYVVGHFHYV LSMGAVFSTI AGYYYWSPQI
410 420 430 440 450
LGLYYNEKLA QIQFWLIFVG ANVTFMPMHF LGINGMPRRI PDYPDAFAGW
460 470 480 490 500
NYVASVGSFI AMISLVLFIY ILYDQFVNGL TNKANNKSVL YTKSPDFVES
510 520 530
NEIFNLNTIK TSSIEFLLTS PPAVHSFNTP AVQS
Length:534
Mass (Da):58,737
Last modified:June 1, 2003 - v1
Checksum:iDE47C9A2F2D513DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ511533 Genomic DNA Translation: CAD54419.1
RefSeqiNP_818778.1, NC_004691.1

Genome annotation databases

GeneIDi807004
KEGGicgr:CaglfMp04

Similar proteinsi

Entry informationi

Entry nameiCOX1_CANGA
AccessioniPrimary (citable) accession number: Q85QA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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