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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Cytochrome oxidase subunit 3
Gene namesi
Name:COX3
Encoded oniMitochondrion
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Mitochondrion

Organism-specific databases

CGDiCAL0139492 COX3
EuPathDBiFungiDB:CaglfMp12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei138 – 160HelicalSequence analysisAdd BLAST23
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837521 – 269Cytochrome c oxidase subunit 3Add BLAST269

Interactioni

Protein-protein interaction databases

STRINGi284593.NP_818786.1

Structurei

3D structure databases

ProteinModelPortaliQ85Q96
SMRiQ85Q96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
HOGENOMiHOG000264954
InParanoidiQ85Q96
KOiK02262
OrthoDBiEOG092C4IN0

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

Q85Q96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLERSRHQ QYPYHMVLPS PWPMLLSFAL LSLTLSLGLT MHGYIGNMNL
60 70 80 90 100
VYLALLVVTL TSVFWFRDVI AEATYLGDHT IAVRKGINLG FLLFVLSEVL
110 120 130 140 150
IFAGLFWAYF HSAMSPDIVL GASWPPVGIQ AVQPTELPLL NTIILLSSGA
160 170 180 190 200
TITYSHHALI CRNRNKALSG LFITIWLIII FVTCQYIEYT NAAFTISDGV
210 220 230 240 250
YGSVFYAGTG LHFLHMVMLA VMLIICYWRM RTYQFTSTHH VGFETTILYC
260
HVLDIIWLFL YIVFYWWGV
Length:269
Mass (Da):30,717
Last modified:June 1, 2003 - v1
Checksum:iB9890E82E064080E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ511533 Genomic DNA Translation: CAD54427.1
RefSeqiNP_818786.1, NC_004691.1

Genome annotation databases

GeneIDi807011
KEGGicgr:CaglfMp12

Similar proteinsi

Entry informationi

Entry nameiCOX3_CANGA
AccessioniPrimary (citable) accession number: Q85Q96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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