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Reviewed, UniProtKB/Swiss-Prot Q85FX6 (ACSF_CYAME)

Last modified June 16, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase
      Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase
    EC=1.14.13.81
Gene names
Name: acsF
Synonyms: ycf59
Encoded onPlastid; Chloroplast
OrganismCyanidioschyzon merolae (Red alga)
Taxonomic identifier45157 [NCBI]
Taxonomic lineageEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidioschyzon

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity.

Catalytic activity

Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840

Cofactor

Iron By similarity.

Pathway

Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840

Subcellular location

Plastidchloroplast. HAMAP MF_01840

Sequence similarities

Belongs to the acsF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840
PRO_0000217542

Sequences

Sequence LengthMass (Da)Tools
Q85FX6-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: BE3A1610AABF2915

FASTA33540,024
        10         20         30         40         50         60 
MQTAVQTQTT VQTLLTPRFY TTDFDQMAKY DISKNRAEIE AIVNEFRKDY NQTHFIRDDE 

        70         80         90        100        110        120 
FDQVWTQMPE SKRQWFKEFL ERSCTAEFSG FLLYKELSRR LKDTNPLLAE GFGYMSRDEA 

       130        140        150        160        170        180 
RHAGFLNKAM ADFGVSLDLG FLTKHRQYTF FAPKFIFYAT YLSEKIGYWR YITIYRHLEA 

       190        200        210        220        230        240 
HPKWSVYPIF KFFEKWCQDE NRHGDFFAAI LKAQPKWITG WASRLWCRFF LLSVFVTMYL 

       250        260        270        280        290        300 
NDLQRKDFYQ LIGLDARAFD WHVIRKTNES AARLFPVVLD VDHVDFVRLM DECACAYAHW 

       310        320        330 
RETQSVLSLA KIFACLFKLY VIKPINTQAL WNTIK 

« Hide

References

[1]"Complete sequence and analysis of the plastid genome of the unicellular red alga Cyanidioschyzon merolae."
Ohta N., Matsuzaki M., Misumi O., Miyagishima S.-Y., Nozaki H., Tanaka K., Shin-i T., Kohara Y., Kuroiwa T.
DNA Res. 10:67-77(2003) [PubMed: 12755171] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 10D.

Cross-references

Sequence databases

AB002583 Genomic DNA. Translation: BAC76217.1.
RefSeqNP_849055.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID845087.
KEGGcme:CMV149C.

Enzyme and pathway databases

BRENDA1.14.13.81. 263380.

Family and domain databases

HAMAPMF_01840.
[Tree]
InterProIPR008434. AcsF.
IPR003251. Rubrerythrin.
[Graphical view]
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACSF_CYAME
AccessionPrimary (citable) accession number: Q85FX6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents