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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Cyanidioschyzon merolae (strain 10D) (Red alga)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Synonyms:odpB
Encoded oniPlastid; Chloroplast
OrganismiCyanidioschyzon merolae (strain 10D) (Red alga)
Taxonomic identifieri280699 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidioschyzon
Proteomesi
  • UP000007014 Componenti: Chloroplast

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002801061 – 326Pyruvate dehydrogenase E1 component subunit betaAdd BLAST326

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

STRINGi45157.CMV154CT.

Structurei

3D structure databases

ProteinModelPortaliQ85FX1.
SMRiQ85FX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
KOiK00162.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiView protein in InterPro
IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
PANTHERiPTHR11624:SF87. PTHR11624:SF87. 1 hit.
PfamiView protein in Pfam
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Q85FX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHKLFMYEA LREAIDEEMA RDKRVFVLGE DVGHYGGSYK VTKQLHTKYG
60 70 80 90 100
DLRVLDTPIA ENSFTGMAIG AAMTGLKPVV EGMNLSFLLL AFNQISNNAG
110 120 130 140 150
MLHYTSGGNW SIPLVIRGPG GIGKQLSAEH SQRIEAYFQA VPGLKIVACS
160 170 180 190 200
TPYNAKGLLK AAIRDNNPVL FLEHVLLYNL KQEIPKQEYV LPLDKAQVVR
210 220 230 240 250
EGSDVTIITY SRMLHHVMQA VKQLVAQGMN PEVIDLISLK PIDLETLVTS
260 270 280 290 300
VSKTHKAIIV EECMQTGGIA AEVMAQIYSH AFDELDAPIR RLSSKDVPTP
310 320
YNGYLEQACL VQPTQIVEAV KTLMST
Length:326
Mass (Da):35,983
Last modified:June 1, 2003 - v1
Checksum:iFA96561EDDF71DF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002583 Genomic DNA. Translation: BAC76222.1.
RefSeqiNP_849060.1. NC_004799.1.

Genome annotation databases

EnsemblPlantsiCMV154CT; CMV154CT; CMV154C.
GeneIDi844910.
GrameneiCMV154CT; CMV154CT; CMV154C.
KEGGicme:CymeCp128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002583 Genomic DNA. Translation: BAC76222.1.
RefSeqiNP_849060.1. NC_004799.1.

3D structure databases

ProteinModelPortaliQ85FX1.
SMRiQ85FX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi45157.CMV154CT.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiCMV154CT; CMV154CT; CMV154C.
GeneIDi844910.
GrameneiCMV154CT; CMV154CT; CMV154C.
KEGGicme:CymeCp128.

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
KOiK00162.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiView protein in InterPro
IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
PANTHERiPTHR11624:SF87. PTHR11624:SF87. 1 hit.
PfamiView protein in Pfam
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiODPB_CYAM1
AccessioniPrimary (citable) accession number: Q85FX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2003
Last modified: February 15, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.