Reviewed, UniProtKB/Swiss-Prot Q85FH0 (NU1C_ADICA)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Adiantum capillus-veneris (Maidenhair fern)

Taxonomic identifier

13818 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Moniliformopses › Filicophyta › Filicopsida › Filicales › Pteridaceae › Adiantum

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.
RNA editing	Edited at positions 44, 47, 50, 54, 129, 263, 267, 271, 356 and 359. The nonsense codon at position 54 is modified to a sense codon. Ref.2

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Coding sequence diversity	RNA editing
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000117504
Regions
	Transmembrane	29 – 49	21	Potential
	Transmembrane	98 – 118	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	177 – 197	21	Potential
	Transmembrane	205 – 225	21	Potential
	Transmembrane	255 – 275	21	Potential
	Transmembrane	310 – 330	21	Potential
	Transmembrane	350 – 370	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q85FH0-1 [UniParc]. Last modified August 16, 2004. Version 2. Checksum: BB056F3F0ABCE513	FASTA	371	40,994
	10 20 30 40 50 60 MINSTEFCRN KLIHLFDELE ITMNLSKSIW IFASTLLLVL GVTMGVLVIV WLERKVSAGV 70 80 90 100 110 120 QQRIGPEYAG PLGIIQSLAD GIKLLLKEDI IPAKGNAWLF AAGPAVVVTP VFITYLVIPF 130 140 150 160 170 180 GQHIILSDLG IGVFFWIAIS SIVPLGLLVA GYGSNNKYSF LGGLRAAAQS ISYEIPLALC 190 200 210 220 230 240 VLSISLLSGS LSTVDIVETQ SKYGFWGWNL WRQPIGFIAF FISSLAECER LPFDLPEAEE 250 260 270 280 290 300 ELVAGYQTEY SGIKFGLFYV GSYLNLLASS LFVVVLYLGG WDFSIPFVEN FGQIVSTSSV 310 320 330 340 350 360 IDKSLDTLKP IVEVATTLSK SYFYLFFSIL TRWTLPRVRM DQLLDLGWKF LLPIALGNLL 370 LTASFRILLI S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of the chloroplast genome from a leptosporangiate fern, Adiantum capillus-veneris L." Wolf P.G., Rowe C.A., Sinclair R.B., Hasebe M. DNA Res. 10:59-65(2003) [PubMed: 12755170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"High levels of RNA editing in a vascular plant chloroplast genome: analysis of transcripts from the fern Adiantum capillus-veneris." Wolf P.G., Rowe C.A., Hasebe M. Gene 339:89-97(2004) [PubMed: 15363849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING. Tissue: Frond.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY178864 Genomic DNA. Translation: AAP29446.2.
RefSeq	NP_848115.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	807455.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_ADICA

Accession

Primary (citable) accession number: Q85FH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	August 16, 2004
Last modified:	June 16, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)