Reviewed, UniProtKB/Swiss-Prot Q85BI5 (NU1C_ANTFO)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Anthoceros formosae (Hornwort)

Taxonomic identifier

48387 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Anthocerotophyta › Anthocerotopsida › Anthocerotidae › Anthocerotales › Anthocerotaceae › Anthoceros

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.
RNA editing	Edited at positions 35, 89, 103, 147, 159, 160, 167, 168, 175, 182, 213, 231, 241, 321, 356 and 357. The nonsense codon at position 168 is modified to a sense codon. Ref.1 Ref.2

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Coding sequence diversity	RNA editing
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000117505
Regions
	Transmembrane	29 – 49	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	130 – 150	21	Potential
	Transmembrane	166 – 186	21	Potential
	Transmembrane	202 – 222	21	Potential
	Transmembrane	254 – 274	21	Potential
	Transmembrane	307 – 327	21	Potential
	Transmembrane	340 – 360	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q85BI5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 74282550B38FD56E	FASTA	366	40,514
	10 20 30 40 50 60 MVFNMNLKEQ AMSLFYESGF PKDFFSFLWI TASILILVSG VVIGVLVIVW LERKISAGIQ 70 80 90 100 110 120 QRIGPEYAGP LGIIQALADG TKLLLKEDII PSRGDALLFS IGPAIVVIPV LLSYLVIPFG 130 140 150 160 170 180 HNIILADLNI GVFFWIAVSS IAPLGLFMAG YGSNNKYSFL GGLRAVAQAI SYEIPLALCV 190 200 210 220 230 240 LSISLLSNSL STVDIVEIQS KFGFWGWNVW RQPIGFIAFL IASLAECERL PFDLPEAEEE 250 260 270 280 290 300 LVAGYQTEYS GIKFGLFYVA SYLNLLVSSL FVTVLYLGGW NLSIPFLPNF PYLEWKFTAE 310 320 330 340 350 360 TSEVINVIIG IIITLAKAYS FLFISIVTRW TLPRVRMDQL LNLGWKFLLP IALGNLLLTA SFQLIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete nucleotide sequence of the hornwort (Anthoceros formosae) chloroplast genome: insight into the earliest land plants." Kugita M., Kaneko A., Yamamoto Y., Takeya Y., Matsumoto T., Yoshinaga K. Nucleic Acids Res. 31:716-721(2003) [PubMed: 12527781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], RNA EDITING. Tissue: Thallus.
[2]	"RNA editing in hornwort chloroplasts makes more than half the genes functional." Kugita M., Yamamoto Y., Fujikawa T., Matsumoto T., Yoshinaga K. Nucleic Acids Res. 31:2417-2423(2003) [PubMed: 12711687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING. Tissue: Thallus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB086179 Genomic DNA. Translation: BAC55406.1. AB087489 mRNA. Translation: BAC55506.1.
RefSeq	NP_777469.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2553493.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_ANTFO

Accession

Primary (citable) accession number: Q85BI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)