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Q859P9

- Q859P9_BPN4

UniProt

Q859P9 - Q859P9_BPN4

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Protein
Submitted name:

Virion RNA polymerase

Gene
N/A
Organism
Enterobacteria phage N4 (Bacteriophage N4)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1421 – 14211AMP
Binding sitei1421 – 14211ATPImported
Binding sitei1421 – 14211GTPImported
Binding sitei1466 – 14661PhosphateImported
Metal bindingi1556 – 15561ManganeseImported
Metal bindingi1557 – 15571Manganese; via carbonyl oxygenImported
Binding sitei1561 – 15611AMP; via amide nitrogen
Binding sitei1609 – 16091ATPImported
Binding sitei1609 – 16091GTPImported
Binding sitei1663 – 16631ATPImported
Binding sitei1663 – 16631GTPImported
Binding sitei1667 – 16671ATPImported
Binding sitei1675 – 16751AMP
Binding sitei1675 – 16751ATPImported
Binding sitei1675 – 16751GTPImported
Metal bindingi1948 – 19481ManganeseImported
Binding sitei1948 – 19481AMP
Binding sitei1948 – 19481ATPImported
Binding sitei1948 – 19481GTPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1434 – 14374GTPImported
Nucleotide bindingi1556 – 15616ATPImported
Nucleotide bindingi1559 – 15613GTPImported
Nucleotide bindingi1667 – 16682GTPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-bindingImported, GTP-bindingImported, ManganeseImported, Metal-bindingImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Virion RNA polymeraseImported
OrganismiEnterobacteria phage N4 (Bacteriophage N4)
Taxonomic identifieri10752 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeN4likevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000001789: Genome

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PO4X-ray2.00A998-2101[»]
3C2PX-ray2.00A/B998-2102[»]
3C3LX-ray2.40A/B998-2102[»]
3C46X-ray2.00A/B998-2102[»]
3Q0AX-ray2.69A/B998-2103[»]
3Q22X-ray2.11A/B998-2103[»]
3Q23X-ray1.80A/B998-2103[»]
3Q24X-ray1.81A/B998-2102[»]
4FF1X-ray2.47A/B998-2103[»]
4FF2X-ray2.00A/B998-2103[»]
4FF3X-ray2.00A/B998-2103[»]
4FF4X-ray2.03A/B998-2103[»]
ProteinModelPortaliQ859P9.
SMRiQ859P9. Positions 1008-2101.

Miscellaneous databases

EvolutionaryTraceiQ859P9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1472 – 14732Phosphate bindingImported

Sequencei

Sequence statusi: Complete.

Q859P9-1 [UniParc]FASTAAdd to Basket

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MSVFDRLAGF ADSVTNAKQV DVSTATAQKK AEQGVTTPLV SPDAAYQMQA     50
ARTGNVGANA FEPGTVQSDF MNLTPMQIMN KYGVEQGLQL INARADAGNQ 100
VFNDSVTTRT PGEELGDIAT GVGLGFVNTL GGIGALGAGL LNDDAGAVVA 150
QQLSKFNDAV HATQSQALQD KRKLFAARNL MNEVESERQY QTDKKEGTND 200
IVASLSKFGR DFVGSIENAA QTDSIISDGL AEGVGSLLGA GPVLRGASLL 250
GKAVVPANTL RSAALAGAID AGTGTQSLAR IASTVGRAAP GMVGVGAMEA 300
GGAYQQTADE IMKMSLKDLE KSPVYQQHIK DGMSPEQARR QTASETGLTA 350
AAIQLPIAAA TGPLVSRFEM APFRAGSLGA VGMNLARETV EEGVQGATGQ 400
LAQNIAQQQN IDKNQDLLKG VGTQAGLGAL YGFGSAGVVQ APAGAARLAG 450
AATAPVLRTT MAGVKAAGSV AGKVVSPIKN TLVARGERVM KQNEEASPVA 500
DDYVAQAAQE AMAQAPEAEV TIRDAVEATD ATPEQKVAAH QYVSDLMNAT 550
RFNPENYQEA PEHIRNAVAG STDQVQVIQK LADLVNTLDE SNPQALMEAA 600
SYMYDAVSEF EQFINRDPAA LDSIPKDSPA IELLNRYTNL TANIQNTPKV 650
IGALNVINRM INESAQNGSL NVTEESSPQE MQNVALAAEV APEKLNPESV 700
NVVLKHAADG RIKLNNRQIA ALQNAAAILK GAREYDAEAA RLGLRPQDIV 750
SKQIKTDESR TQEGQYSALQ HANRIRSAYN SGNFELASAY LNDFMQFAQH 800
MQNKVGALNE HLVTGNADKN KSVHYQALTA DREWVRSRTG LGVNPYDTKS 850
VKFAQQVALE AKTVADIANA LASAYPELKV SHIKVTPLDS RLNAPAAEVV 900
KAFRQGNRDV ASSQPKADSV NQVKETPVTK QEPVTSTVQT KTPVSESVKT 950
EPTTKESSPQ AIKEPVNQSE KQDVNLTNED NIKQPTESVK ETETSTKEST 1000
VTEELKEGID AVYPSLVGTA DSKAEGIKNY FKLSFTLPEE QKSRTVGSEA 1050
PLKDVAQALS SRARYELFTE KETANPAFNG EVIKRYKELM EHGEGIADIL 1100
RSRLAKFLNT KDVGKRFAQG TEANRWVGGK LLNIVEQDGD TFKYNEQLLQ 1150
TAVLAGLQWR LTATSNTAIK DAKDVAAITG IDQALLPEGL VEQFDTGMTL 1200
TEAVSSLAQK IESYWGLSRN PNAPLGYTKG IPTAMAAEIL AAFVESTDVV 1250
ENIVDMSEID PDNKKTIGLY TITELDSFDP INSFPTAIEE AVLVNPTEKM 1300
FFGDDIPPVA NTQLRNPAVR NTPEQKAALK AEQATEFYVH TPMVQFYETL 1350
GKDRILELMG AGTLNKELLN DNHAKSLEGK NRSVEDSYNQ LFSVIEQVRA 1400
QSEDISTVPI HYAYNMTRVG RMQMLGKYNP QSAKLVREAI LPTKATLDLS 1450
NQNNEDFSAF QLGLAQALDI KVHTMTREVM SDELTKLLEG NLKPAIDMMV 1500
EFNTTGSLPE NAVDVLNTAL GDRKSFVALM ALMEYSRYLV AEDKSAFVTP 1550
LYVEADGVTN GPINAMMLMT GGLFTPDWIR NIAKGGLFIG SPNKTMNEHR 1600
STADNNDLYQ ASTNALMESL GKLRSNYASN MPIQSQIDSL LSLMDLFLPD 1650
INLGENGALE LKRGIAKNPL TITIYGSGAR GIAGKLVSSV TDAIYERMSD 1700
VLKARAKDPN ISAAMAMFGK QAASEAHAEE LLARFLKDME TLTSTVPVKR 1750
KGVLELQSTG TGAKGKINPK TYTIKGEQLK ALQENMLHFF VEPLRNGITQ 1800
TVGESLVYST EQLQKATQIQ SVVLEDMFKQ RVQEKLAEKA KDPTWKKGDF 1850
LTQKELNDIQ ASLNNLAPMI ETGSQTFYIA GSENAEVANQ VLATNLDDRM 1900
RVPMSIYAPA QAGVAGIPFM TIGTGDGMMM QTLSTMKGAP KNTLKIFDGM 1950
NIGLNDITDA SRKANEAVYT SWQGNPIKNV YESYAKFMKN VDFSKLSPEA 2000
LEAIGKSALE YDQRENATVD DIANAASLIE RNLRNIALGV DIRHKVLDKV 2050
NLSIDQMAAV GAPYQNNGKI DLSNMTPEQQ ADELNKLFRE ELEARKQKVA 2100
KARAEVKEET VSEKEPVNPD FGMVGREHKA SGVRILSATA IRNLAKISNL 2150
PSTQAATLAE IQKSLAAKDY KIIYGTPTQV AEYARQKNVT ELTSQEMEEA 2200
QAGNIYGWTN FDDKTIYLVS PSMETLIHEL VHASTFEEVY SFYQGNEVSP 2250
TSKQAIENLE GLMEQFRSLD ISKDSPEMRE AYADAIATIE GHLSNGFVDP 2300
AISKAAALNE FMAWGLANRA LAAKQKRTSS LVQMVKDVYQ AIKKLIWGRK 2350
QAPALGEDMF SNLLFNSAIL MRSQPTTQAV AKDGTLFHSK AYGNNERLSQ 2400
LNQTFDKLVT DYLRTDPVTE VERRGNVANA LMSATRLVRD VQSHGFNMTA 2450
QEQSVFQMVT AALATEAAID PHAMARAQEL YTHVMKHLTV EHFMADPDST 2500
NPADRYYAQQ KYDTISGANL VEVDAKGRTS LLPTFLGLAM VNEELRSIIK 2550
EMPVPKADKK LGNDIDTLLT NAGTQVMESL NRRMAGDQKA TNVQDSIDAL 2600
SETIMAAALK RESFYDAVAT PTGNFIDRAN QYVTDSIERL SETVIEKADK 2650
VIANPSNIAA KGVAHLAKLT AAIASEKQGE IVAQGVMTAM NQGKVWQPFH 2700
DLVNDIVGRT KTNANVYDLI KLVKSQISQD RQQFREHLPT VIAGKFSRKL 2750
TDTEWSAMHT GLGKTDLAVL RETMSMAEIR DLLSSSKKVK DEISTLEKEI 2800
QNQAGRNWNL VQKKSKQLAQ YMIMGEVGNN LLRNAHAISR LLGERITNGP 2850
VADVAAIDKL ITLYSLELMN KSDRDLLSEL AQSEVEGMEF SIAYMVGQRT 2900
EEMRKAKGDN RTLLNHFKGY IPVENQQGVN LIIADDKEFA KLNSQSFTRI 2950
GTYQGSTGFR TGSKGYYFSP VAARAPYSQG ILQNVRNTAG GVDIGTGFTL 3000
GTMVAGRITD KPTVERITKA LAKGERGREP LMPIYNSKGQ VVAYEQSVDP 3050
NMLKHLNQDN HFAKMVGVWR GRQVEEAKAQ RFNDILIEQL HAMYEKDIKD 3100
SSANKSQYVN LLGKIDDPVL ADAINLMNIE TRHKAEELFG KDELWVRRDM 3150
LNDALGYRAA SIGDVWTGNS RWSPSTLDTV KKMFLGAFGN KAYHVVMNAE 3200
NTIQNLVKDA KTVIVVKSVV VPAVNFLANI YQMIGRGVPV KDIAVNIPRK 3250
TSEINQYIKS RLRQIDAEAE LRAAEGNPNL VRKLKTEIQS ITDSHRRMSI 3300
WPLIEAGEFS SIADAGISRD DLLVAEGKIH EYMEKLANKL PEKVRNAGRY 3350
ALIAKDTALF QGIQKTVEYS DFIAKAIIYD DLVKRKKKSS SEALGQVTEE 3400
FINYDRLPGR FRGYMESMGL MWFYNFKIRS IKVAMSMIRN NPVHSLIATV 3450
VPAPTMFGNV GLPIQDNMLT MLAEGRLDYS LGFGQGLRAP TLNPWFNLTH 3500
Length:3,500
Mass (Da):382,495
Last modified:December 12, 2006 - v2
Checksum:iB4A52EAC2E28BBDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF056009 Genomic DNA. Translation: AAO24831.2.
RefSeqiYP_950528.1. NC_008720.1.

Genome annotation databases

GeneIDi5075715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF056009 Genomic DNA. Translation: AAO24831.2 .
RefSeqi YP_950528.1. NC_008720.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PO4 X-ray 2.00 A 998-2101 [» ]
3C2P X-ray 2.00 A/B 998-2102 [» ]
3C3L X-ray 2.40 A/B 998-2102 [» ]
3C46 X-ray 2.00 A/B 998-2102 [» ]
3Q0A X-ray 2.69 A/B 998-2103 [» ]
3Q22 X-ray 2.11 A/B 998-2103 [» ]
3Q23 X-ray 1.80 A/B 998-2103 [» ]
3Q24 X-ray 1.81 A/B 998-2102 [» ]
4FF1 X-ray 2.47 A/B 998-2103 [» ]
4FF2 X-ray 2.00 A/B 998-2103 [» ]
4FF3 X-ray 2.00 A/B 998-2103 [» ]
4FF4 X-ray 2.03 A/B 998-2103 [» ]
ProteinModelPortali Q859P9.
SMRi Q859P9. Positions 1008-2101.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5075715.

Miscellaneous databases

EvolutionaryTracei Q859P9.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence and analysis of bacteriophage N4."
    Hendrix R.W., Rothman-Denes L., Hatfull G.F., Lawrence J.G., Pedulla M.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase."
    Gleghorn M.L., Davydova E.K., Rothman-Denes L.B., Murakami K.S.
    Mol. Cell 32:707-717(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 998-2102.
  3. "X-ray crystal structure of the polymerase domain of the bacteriophage N4 virion RNA polymerase."
    Murakami K.S., Davydova E.K., Rothman-Denes L.B.
    Proc. Natl. Acad. Sci. U.S.A. 105:5046-5051(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 998-2101.
  4. "X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides."
    Gleghorn M.L., Davydova E.K., Basu R., Rothman-Denes L.B., Murakami K.S.
    Proc. Natl. Acad. Sci. U.S.A. 108:3566-3571(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 998-2103 IN COMPLEX WITH GTP; MANGANESE AND PHOSPHATE.
  5. "Watching the bacteriophage N4 RNA polymerase transcription by time-dependent soak-trigger-freeze X-ray crystallography."
    Basu R.S., Murakami K.S.
    J. Biol. Chem. 288:3305-3311(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 998-2103 IN COMPLEX WITH AMP; ATP; MANGANESE AND PHOSPHATE.

Entry informationi

Entry nameiQ859P9_BPN4
AccessioniPrimary (citable) accession number: Q859P9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: December 12, 2006
Last modified: June 11, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3