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Q857H2

- VG50_BPMB2

UniProt

Q857H2 - VG50_BPMB2

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Protein
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
Gene
50
Organism
Mycobacterium phage Bxz2 (Mycobacteriophage Bxz2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei356 – 3561 By similarity
Active sitei358 – 3581 By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Alternative name(s):
Gp50
Gene namesi
Name:50
OrganismiMycobacterium phage Bxz2 (Mycobacteriophage Bxz2)
Taxonomic identifieri205870 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
Virus hostiMycobacterium [TaxID: 1763]
ProteomesiUP000000729: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000221429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi86 ↔ 367Redox-active By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ857H2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 3 hits.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q857H2-1 [UniParc]FASTAAdd to Basket

« Hide

MTNWGPTGEL VYNRTYSRTK PDGSKETWPE TVRRVVDGNL ALVDERYHLP    50
GERADLIRLM EEFKILPGGR HLWASGVKNA QHLFNCWVSG WTEKPSDHFE 100
FTFMRLMEGG GVGANYSNRF IDYGPVQQEL YVHIVCDPDH PDYEAMKEAG 150
VLSTEYDPDW AGAFVIEDSR EGWAAALVDL IDTHYRDEVS HFQRVYDVSR 200
VRQFGAKLKT FGGTASGPLP LARMLIDVCE ILSEIATEGG QLTGIAAMEI 250
DHAIAQCVVA GGVRRSARMS MMHWKDPQVY EFLRIKQDTG SHWTTNISLE 300
VDDEFWVAVE EGWAGPNNRI LRELTEGMVA NGEPGFWNSS LSNVGEPNEV 350
VCTNPCGEIT LEPWEPCNLG HVNLAAFAHG NGSYDITGLY RAHRLVTRFL 400
MRATFSPVAD PKSREVLDRN RRIGVGHLGV ASFLALCGWK YSEARTNEEF 450
KWLLRSLAEE VDHAATQFAH QLRIPVPVKK RTVAPTGTIA KMPGVSEGIH 500
PIFSRYFIRR VRLSMSDPDQ TRMLADYGRQ GYEVEDDLYA KFTGVVSIPT 550
QDTLVAEVIE HYGQDSESLV ESAADLSLNE LLGFQALYQT IWADNAVSFT 600
ANVDPETYNA DDVRQQLRLF GGLLKGATIF PEASMPQAPY ERITKEQYEQ 650
ATAKAVADGV DEDCANGACP IR 672
Length:672
Mass (Da):75,158
Last modified:June 1, 2003 - v1
Checksum:iF1C8F1FFBEA25E12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY129332 Genomic DNA. Translation: AAN01804.1.
RefSeqiNP_817639.1. NC_004682.1.

Genome annotation databases

GeneIDi1259263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY129332 Genomic DNA. Translation: AAN01804.1 .
RefSeqi NP_817639.1. NC_004682.1.

3D structure databases

ProteinModelPortali Q857H2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1259263.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 3 hits.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVG50_BPMB2
AccessioniPrimary (citable) accession number: Q857H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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