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Q857H2

- VG50_BPMB2

UniProt

Q857H2 - VG50_BPMB2

Protein

Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

50

Organism
Mycobacterium phage Bxz2 (Mycobacteriophage Bxz2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei356 – 3561By similarity
    Active sitei358 – 3581By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Alternative name(s):
    Gp50
    Gene namesi
    Name:50
    OrganismiMycobacterium phage Bxz2 (Mycobacteriophage Bxz2)
    Taxonomic identifieri205870 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
    Virus hostiMycobacterium [TaxID: 1763]
    ProteomesiUP000000729: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 672672Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000221429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi86 ↔ 367Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ857H2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 3 hits.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q857H2-1 [UniParc]FASTAAdd to Basket

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    MTNWGPTGEL VYNRTYSRTK PDGSKETWPE TVRRVVDGNL ALVDERYHLP    50
    GERADLIRLM EEFKILPGGR HLWASGVKNA QHLFNCWVSG WTEKPSDHFE 100
    FTFMRLMEGG GVGANYSNRF IDYGPVQQEL YVHIVCDPDH PDYEAMKEAG 150
    VLSTEYDPDW AGAFVIEDSR EGWAAALVDL IDTHYRDEVS HFQRVYDVSR 200
    VRQFGAKLKT FGGTASGPLP LARMLIDVCE ILSEIATEGG QLTGIAAMEI 250
    DHAIAQCVVA GGVRRSARMS MMHWKDPQVY EFLRIKQDTG SHWTTNISLE 300
    VDDEFWVAVE EGWAGPNNRI LRELTEGMVA NGEPGFWNSS LSNVGEPNEV 350
    VCTNPCGEIT LEPWEPCNLG HVNLAAFAHG NGSYDITGLY RAHRLVTRFL 400
    MRATFSPVAD PKSREVLDRN RRIGVGHLGV ASFLALCGWK YSEARTNEEF 450
    KWLLRSLAEE VDHAATQFAH QLRIPVPVKK RTVAPTGTIA KMPGVSEGIH 500
    PIFSRYFIRR VRLSMSDPDQ TRMLADYGRQ GYEVEDDLYA KFTGVVSIPT 550
    QDTLVAEVIE HYGQDSESLV ESAADLSLNE LLGFQALYQT IWADNAVSFT 600
    ANVDPETYNA DDVRQQLRLF GGLLKGATIF PEASMPQAPY ERITKEQYEQ 650
    ATAKAVADGV DEDCANGACP IR 672
    Length:672
    Mass (Da):75,158
    Last modified:June 1, 2003 - v1
    Checksum:iF1C8F1FFBEA25E12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY129332 Genomic DNA. Translation: AAN01804.1.
    RefSeqiNP_817639.1. NC_004682.1.

    Genome annotation databases

    GeneIDi1259263.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY129332 Genomic DNA. Translation: AAN01804.1 .
    RefSeqi NP_817639.1. NC_004682.1.

    3D structure databases

    ProteinModelPortali Q857H2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1259263.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 3 hits.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiVG50_BPMB2
    AccessioniPrimary (citable) accession number: Q857H2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3