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Protein

Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

50

Organism
Mycobacterium phage Bxz2 (Mycobacteriophage Bxz2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei356 – 3561By similarity
Active sitei358 – 3581By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Alternative name(s):
Gp50
Gene namesi
Name:50
OrganismiMycobacterium phage Bxz2 (Mycobacteriophage Bxz2)
Taxonomic identifieri205870 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
Virus hostiMycobacterium [TaxID: 1763]
ProteomesiUP000000729 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Putative adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000221429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi86 ↔ 367Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ857H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 3 hits.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q857H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNWGPTGEL VYNRTYSRTK PDGSKETWPE TVRRVVDGNL ALVDERYHLP
60 70 80 90 100
GERADLIRLM EEFKILPGGR HLWASGVKNA QHLFNCWVSG WTEKPSDHFE
110 120 130 140 150
FTFMRLMEGG GVGANYSNRF IDYGPVQQEL YVHIVCDPDH PDYEAMKEAG
160 170 180 190 200
VLSTEYDPDW AGAFVIEDSR EGWAAALVDL IDTHYRDEVS HFQRVYDVSR
210 220 230 240 250
VRQFGAKLKT FGGTASGPLP LARMLIDVCE ILSEIATEGG QLTGIAAMEI
260 270 280 290 300
DHAIAQCVVA GGVRRSARMS MMHWKDPQVY EFLRIKQDTG SHWTTNISLE
310 320 330 340 350
VDDEFWVAVE EGWAGPNNRI LRELTEGMVA NGEPGFWNSS LSNVGEPNEV
360 370 380 390 400
VCTNPCGEIT LEPWEPCNLG HVNLAAFAHG NGSYDITGLY RAHRLVTRFL
410 420 430 440 450
MRATFSPVAD PKSREVLDRN RRIGVGHLGV ASFLALCGWK YSEARTNEEF
460 470 480 490 500
KWLLRSLAEE VDHAATQFAH QLRIPVPVKK RTVAPTGTIA KMPGVSEGIH
510 520 530 540 550
PIFSRYFIRR VRLSMSDPDQ TRMLADYGRQ GYEVEDDLYA KFTGVVSIPT
560 570 580 590 600
QDTLVAEVIE HYGQDSESLV ESAADLSLNE LLGFQALYQT IWADNAVSFT
610 620 630 640 650
ANVDPETYNA DDVRQQLRLF GGLLKGATIF PEASMPQAPY ERITKEQYEQ
660 670
ATAKAVADGV DEDCANGACP IR
Length:672
Mass (Da):75,158
Last modified:June 1, 2003 - v1
Checksum:iF1C8F1FFBEA25E12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129332 Genomic DNA. Translation: AAN01804.1.
RefSeqiNP_817639.1. NC_004682.1.

Genome annotation databases

GeneIDi1259263.
KEGGivg:1259263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129332 Genomic DNA. Translation: AAN01804.1.
RefSeqiNP_817639.1. NC_004682.1.

3D structure databases

ProteinModelPortaliQ857H2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1259263.
KEGGivg:1259263.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 3 hits.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVG50_BPMB2
AccessioniPrimary (citable) accession number: Q857H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.