ID   CAPSD_RHDVR             Reviewed;         576 AA.
AC   Q85433;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   08-NOV-2023, entry version 65.
DE   RecName: Full=Subgenomic capsid protein VP60;
OS   Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Caliciviridae; Lagovirus; Rabbit hemorrhagic disease virus.
OX   NCBI_TaxID=314539;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8970986; DOI=10.1128/jvi.70.12.8614-8623.1996;
RA   Capucci L., Fusi P., Lavazza A., Pacciarini M.L., Rossi C.;
RT   "Detection and preliminary characterization of a new rabbit calicivirus
RT   related to rabbit hemorrhagic disease virus but nonpathogenic.";
RL   J. Virol. 70:8614-8623(1996).
CC   -!- FUNCTION: Capsid protein VP60 self assembles to form an icosahedral
CC       capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of
CC       180 capsid proteins. A smaller form of capsid with a diameter of 23 nm
CC       might be capsid proteins assembled as icosahedron with T=1 symmetry.
CC       The capsid encapsulate VP2 proteins and genomic or subgenomic RNA.
CC       Attaches virion to target cells by binding histo-blood group antigens,
CC       inducing endocytosis of the viral particle. Acidification of the
CC       endosome induces conformational change of capsid protein thereby
CC       injecting virus genomic RNA into host cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimerizes, then multimerizes. Binds to histo-blood group
CC       antigens at surface of target cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC   -!- PTM: The N-terminus is blocked. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Two different RNAs lead the expression of the capsid
CC       protein. One arises from the cleavage of the polyprotein translated
CC       from the genomic RNA and the other from the translation of a subgenomic
CC       RNA derived from the (-)RNA template. Capsid protein expressed from the
CC       subgenomic mRNA is produced in much larger amounts than the cleaved one
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the caliciviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; X96868; CAA65611.1; -; mRNA.
DR   SMR; Q85433; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039617; C:T=3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR   CDD; cd00205; rhv_like; 1.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR004005; Calicivirus_coat.
DR   InterPro; IPR033703; Rhv-like.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF00915; Calici_coat; 1.
DR   SUPFAM; SSF88633; Positive stranded ssRNA viruses; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Host cytoplasm; T=3 icosahedral capsid protein; Virion.
FT   CHAIN           1..576
FT                   /note="Subgenomic capsid protein VP60"
FT                   /id="PRO_0000100120"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   576 AA;  60151 MW;  44FFB9F3E2149E32 CRC64;
     MEGKARITPQ GEAAGTATTA SVPGTTTDGM DPGVVATTSV VTTENASTSV ATAGIGGPPQ
     QVDQQETWRT NFYYNDVFTW SVADAPGSIL YTVQHSPQNN PFTAVLSQMY AGWAGGMQFR
     FIVAGSGVFG GRLVAAVIPP GIEIGPGLEV RQFPHVVIDA RSLEPVTITM PDLRPNMYHP
     TGDPGLVPTL VLSVYNNLIN PFGGSTSAIQ VTVETRPSED FEFVMIRAPS SKTVDSVTPA
     GLLTTPVLTG VGTDNRWNCQ IVGLQPVPGG LSTCNRHWNL NGSTYGWSSP RFTDIDHRRG
     ASQPGGNNVL QFWYANAGSA VDNPICQVAP DGFPDMSFVP LNGPNVPTAG WVGFGAIWNS
     NSGAPNVTTV QAYELGFATG APNNLQPATN TSGSQIVAKS IYAVSTGANQ NPAGLFVMAS
     GVISTPTARA ITYTPQPDRI VNAPGTPAAA PVGKNVPIMF ASVVRRTGDV NAEAGSDNGT
     QYGTGSQPLP VTIGLSLNNY SSALTPGQFF VWQLNFASGF MEIGLNVDGY FYAGTGASTT
     LIDLTELIDI RPVGPRPSTS TLVFNLGGAT SGFSYV
//