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Q85433 (CAPSD_RHDVR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Subgenomic capsid protein VP60
OrganismRabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
Taxonomic identifier314539 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
Virus hostOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.

Subunit structure

Homodimerizes, then multimerizes. Binds to histo-blood group antigens at surface of target cells By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Post-translational modification

The N-terminus is blocked By similarity.

Miscellaneous

Two differents RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one By similarity.

Sequence similarities

Belongs to the caliciviridae capsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Subgenomic capsid protein VP60
PRO_0000100120

Sequences

Sequence LengthMass (Da)Tools
Q85433 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 44FFB9F3E2149E32

FASTA57660,151
        10         20         30         40         50         60 
MEGKARITPQ GEAAGTATTA SVPGTTTDGM DPGVVATTSV VTTENASTSV ATAGIGGPPQ 

        70         80         90        100        110        120 
QVDQQETWRT NFYYNDVFTW SVADAPGSIL YTVQHSPQNN PFTAVLSQMY AGWAGGMQFR 

       130        140        150        160        170        180 
FIVAGSGVFG GRLVAAVIPP GIEIGPGLEV RQFPHVVIDA RSLEPVTITM PDLRPNMYHP 

       190        200        210        220        230        240 
TGDPGLVPTL VLSVYNNLIN PFGGSTSAIQ VTVETRPSED FEFVMIRAPS SKTVDSVTPA 

       250        260        270        280        290        300 
GLLTTPVLTG VGTDNRWNCQ IVGLQPVPGG LSTCNRHWNL NGSTYGWSSP RFTDIDHRRG 

       310        320        330        340        350        360 
ASQPGGNNVL QFWYANAGSA VDNPICQVAP DGFPDMSFVP LNGPNVPTAG WVGFGAIWNS 

       370        380        390        400        410        420 
NSGAPNVTTV QAYELGFATG APNNLQPATN TSGSQIVAKS IYAVSTGANQ NPAGLFVMAS 

       430        440        450        460        470        480 
GVISTPTARA ITYTPQPDRI VNAPGTPAAA PVGKNVPIMF ASVVRRTGDV NAEAGSDNGT 

       490        500        510        520        530        540 
QYGTGSQPLP VTIGLSLNNY SSALTPGQFF VWQLNFASGF MEIGLNVDGY FYAGTGASTT 

       550        560        570 
LIDLTELIDI RPVGPRPSTS TLVFNLGGAT SGFSYV 

« Hide

References

[1]"Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic."
Capucci L., Fusi P., Lavazza A., Pacciarini M.L., Rossi C.
J. Virol. 70:8614-8623(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96868 mRNA. Translation: CAA65611.1.

3D structure databases

ProteinModelPortalQ85433.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.20. 1 hit.
InterProIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamPF00915. Calici_coat. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPSD_RHDVR
AccessionPrimary (citable) accession number: Q85433
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families