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Q85433

- CAPSD_RHDVR

UniProt

Q85433 - CAPSD_RHDVR

Protein

Subgenomic capsid protein VP60

Gene
N/A
Organism
Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Subgenomic capsid protein VP60
    OrganismiRabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
    Taxonomic identifieri314539 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
    Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. T=3 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Subgenomic capsid protein VP60PRO_0000100120Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.By similarity

    Interactioni

    Subunit structurei

    Homodimerizes, then multimerizes. Binds to histo-blood group antigens at surface of target cells By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ85433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.120.20. 1 hit.
    InterProiIPR004005. Calicivirus_coat.
    IPR029053. Viral_coat.
    [Graphical view]
    PfamiPF00915. Calici_coat. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q85433-1 [UniParc]FASTAAdd to Basket

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    MEGKARITPQ GEAAGTATTA SVPGTTTDGM DPGVVATTSV VTTENASTSV    50
    ATAGIGGPPQ QVDQQETWRT NFYYNDVFTW SVADAPGSIL YTVQHSPQNN 100
    PFTAVLSQMY AGWAGGMQFR FIVAGSGVFG GRLVAAVIPP GIEIGPGLEV 150
    RQFPHVVIDA RSLEPVTITM PDLRPNMYHP TGDPGLVPTL VLSVYNNLIN 200
    PFGGSTSAIQ VTVETRPSED FEFVMIRAPS SKTVDSVTPA GLLTTPVLTG 250
    VGTDNRWNCQ IVGLQPVPGG LSTCNRHWNL NGSTYGWSSP RFTDIDHRRG 300
    ASQPGGNNVL QFWYANAGSA VDNPICQVAP DGFPDMSFVP LNGPNVPTAG 350
    WVGFGAIWNS NSGAPNVTTV QAYELGFATG APNNLQPATN TSGSQIVAKS 400
    IYAVSTGANQ NPAGLFVMAS GVISTPTARA ITYTPQPDRI VNAPGTPAAA 450
    PVGKNVPIMF ASVVRRTGDV NAEAGSDNGT QYGTGSQPLP VTIGLSLNNY 500
    SSALTPGQFF VWQLNFASGF MEIGLNVDGY FYAGTGASTT LIDLTELIDI 550
    RPVGPRPSTS TLVFNLGGAT SGFSYV 576
    Length:576
    Mass (Da):60,151
    Last modified:November 1, 1996 - v1
    Checksum:i44FFB9F3E2149E32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96868 mRNA. Translation: CAA65611.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96868 mRNA. Translation: CAA65611.1 .

    3D structure databases

    ProteinModelPortali Q85433.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.20. 1 hit.
    InterProi IPR004005. Calicivirus_coat.
    IPR029053. Viral_coat.
    [Graphical view ]
    Pfami PF00915. Calici_coat. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic."
      Capucci L., Fusi P., Lavazza A., Pacciarini M.L., Rossi C.
      J. Virol. 70:8614-8623(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCAPSD_RHDVR
    AccessioniPrimary (citable) accession number: Q85433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Two differents RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one By similarity.By similarity

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3