Q85433 (CAPSD_RHDVR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Subgenomic capsid protein VP60
Organism	Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
Taxonomic identifier	314539 [NCBI]
Taxonomic lineage	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Lagovirus › Rabbit hemorrhagic disease virus
Virus host	Oryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.
Subunit structure	Homodimerizes, then multimerizes. Binds to histo-blood group antigens at surface of target cells By similarity.
Subcellular location	Virion. Host cytoplasm By similarity.
Post-translational modification	The N-terminus is blocked By similarity.
Miscellaneous	Two differents RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one By similarity.
Sequence similarities	Belongs to the caliciviridae capsid protein family.

Ontologies

Keywords
Cellular component	Host cytoplasm Virion
Molecular function	Capsid protein T=3 icosahedral capsid protein
Gene Ontology (GO)
Cellular_component	T=3 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Subgenomic capsid protein VP60		PRO_0000100120

Sequences

	Sequence		Length	Mass (Da)
	Q85433 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 44FFB9F3E2149E32	FASTA	576	60,151
	10 20 30 40 50 60 MEGKARITPQ GEAAGTATTA SVPGTTTDGM DPGVVATTSV VTTENASTSV ATAGIGGPPQ 70 80 90 100 110 120 QVDQQETWRT NFYYNDVFTW SVADAPGSIL YTVQHSPQNN PFTAVLSQMY AGWAGGMQFR 130 140 150 160 170 180 FIVAGSGVFG GRLVAAVIPP GIEIGPGLEV RQFPHVVIDA RSLEPVTITM PDLRPNMYHP 190 200 210 220 230 240 TGDPGLVPTL VLSVYNNLIN PFGGSTSAIQ VTVETRPSED FEFVMIRAPS SKTVDSVTPA 250 260 270 280 290 300 GLLTTPVLTG VGTDNRWNCQ IVGLQPVPGG LSTCNRHWNL NGSTYGWSSP RFTDIDHRRG 310 320 330 340 350 360 ASQPGGNNVL QFWYANAGSA VDNPICQVAP DGFPDMSFVP LNGPNVPTAG WVGFGAIWNS 370 380 390 400 410 420 NSGAPNVTTV QAYELGFATG APNNLQPATN TSGSQIVAKS IYAVSTGANQ NPAGLFVMAS 430 440 450 460 470 480 GVISTPTARA ITYTPQPDRI VNAPGTPAAA PVGKNVPIMF ASVVRRTGDV NAEAGSDNGT 490 500 510 520 530 540 QYGTGSQPLP VTIGLSLNNY SSALTPGQFF VWQLNFASGF MEIGLNVDGY FYAGTGASTT 550 560 570 LIDLTELIDI RPVGPRPSTS TLVFNLGGAT SGFSYV

References

[1]	"Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic." Capucci L., Fusi P., Lavazza A., Pacciarini M.L., Rossi C. J. Virol. 70:8614-8623(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X96868 mRNA. Translation: CAA65611.1.
3D structure databases
ProteinModelPortal	Q85433.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004005. Calicivirus_coat. [Graphical view]
Pfam	PF00915. Calici_coat. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPSD_RHDVR

Accession

Primary (citable) accession number: Q85433

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program