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Q85433

- CAPSD_RHDVR

UniProt

Q85433 - CAPSD_RHDVR

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Protein
Subgenomic capsid protein VP60
Gene
N/A
Organism
Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Subgenomic capsid protein VP60
OrganismiRabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
Taxonomic identifieri314539 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. T=3 icosahedral viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Subgenomic capsid protein VP60
PRO_0000100120Add
BLAST

Post-translational modificationi

The N-terminus is blocked By similarity.

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. Binds to histo-blood group antigens at surface of target cells By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ85433.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q85433-1 [UniParc]FASTAAdd to Basket

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MEGKARITPQ GEAAGTATTA SVPGTTTDGM DPGVVATTSV VTTENASTSV    50
ATAGIGGPPQ QVDQQETWRT NFYYNDVFTW SVADAPGSIL YTVQHSPQNN 100
PFTAVLSQMY AGWAGGMQFR FIVAGSGVFG GRLVAAVIPP GIEIGPGLEV 150
RQFPHVVIDA RSLEPVTITM PDLRPNMYHP TGDPGLVPTL VLSVYNNLIN 200
PFGGSTSAIQ VTVETRPSED FEFVMIRAPS SKTVDSVTPA GLLTTPVLTG 250
VGTDNRWNCQ IVGLQPVPGG LSTCNRHWNL NGSTYGWSSP RFTDIDHRRG 300
ASQPGGNNVL QFWYANAGSA VDNPICQVAP DGFPDMSFVP LNGPNVPTAG 350
WVGFGAIWNS NSGAPNVTTV QAYELGFATG APNNLQPATN TSGSQIVAKS 400
IYAVSTGANQ NPAGLFVMAS GVISTPTARA ITYTPQPDRI VNAPGTPAAA 450
PVGKNVPIMF ASVVRRTGDV NAEAGSDNGT QYGTGSQPLP VTIGLSLNNY 500
SSALTPGQFF VWQLNFASGF MEIGLNVDGY FYAGTGASTT LIDLTELIDI 550
RPVGPRPSTS TLVFNLGGAT SGFSYV 576
Length:576
Mass (Da):60,151
Last modified:November 1, 1996 - v1
Checksum:i44FFB9F3E2149E32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96868 mRNA. Translation: CAA65611.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96868 mRNA. Translation: CAA65611.1 .

3D structure databases

ProteinModelPortali Q85433.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
InterProi IPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic."
    Capucci L., Fusi P., Lavazza A., Pacciarini M.L., Rossi C.
    J. Virol. 70:8614-8623(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCAPSD_RHDVR
AccessioniPrimary (citable) accession number: Q85433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Two differents RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one By similarity.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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