Q85433 (CAPSD_RHDVR) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 41. History...
Names and origin
|Protein names||Recommended name:|
Subgenomic capsid protein VP60
|Organism||Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)|
|Taxonomic identifier||314539 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Lagovirus ›|
|Virus host||Oryctolagus cuniculus (Rabbit) [TaxID: 9986]|
|Sequence length||576 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.
Homodimerizes, then multimerizes. Binds to histo-blood group antigens at surface of target cells By similarity.
The N-terminus is blocked By similarity.
Two differents RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one By similarity.
Belongs to the caliciviridae capsid protein family.
|Cellular component||Host cytoplasm|
|Molecular function||Capsid protein|
T=3 icosahedral capsid protein
|Gene Ontology (GO)|
|Cellular_component||T=3 icosahedral viral capsid|
Inferred from electronic annotation. Source: UniProtKB-KWhost cell cytoplasm
Inferred from electronic annotation. Source: UniProtKB-SubCell
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 576||576||Subgenomic capsid protein VP60||PRO_0000100120|
|X96868 mRNA. Translation: CAA65611.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR004005. Calicivirus_coat. |
|Pfam||PF00915. Calici_coat. 1 hit. |
|Accession||Primary (citable) accession number: Q85433|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families