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Q85433

- CAPSD_RHDVR

UniProt

Q85433 - CAPSD_RHDVR

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Protein

Subgenomic capsid protein VP60

Gene
N/A
Organism
Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Subgenomic capsid protein VP60
OrganismiRabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)
Taxonomic identifieri314539 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeLagovirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. T=3 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Subgenomic capsid protein VP60PRO_0000100120Add
BLAST

Post-translational modificationi

The N-terminus is blocked.By similarity

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. Binds to histo-blood group antigens at surface of target cells (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ85433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q85433-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MEGKARITPQ GEAAGTATTA SVPGTTTDGM DPGVVATTSV VTTENASTSV
60 70 80 90 100
ATAGIGGPPQ QVDQQETWRT NFYYNDVFTW SVADAPGSIL YTVQHSPQNN
110 120 130 140 150
PFTAVLSQMY AGWAGGMQFR FIVAGSGVFG GRLVAAVIPP GIEIGPGLEV
160 170 180 190 200
RQFPHVVIDA RSLEPVTITM PDLRPNMYHP TGDPGLVPTL VLSVYNNLIN
210 220 230 240 250
PFGGSTSAIQ VTVETRPSED FEFVMIRAPS SKTVDSVTPA GLLTTPVLTG
260 270 280 290 300
VGTDNRWNCQ IVGLQPVPGG LSTCNRHWNL NGSTYGWSSP RFTDIDHRRG
310 320 330 340 350
ASQPGGNNVL QFWYANAGSA VDNPICQVAP DGFPDMSFVP LNGPNVPTAG
360 370 380 390 400
WVGFGAIWNS NSGAPNVTTV QAYELGFATG APNNLQPATN TSGSQIVAKS
410 420 430 440 450
IYAVSTGANQ NPAGLFVMAS GVISTPTARA ITYTPQPDRI VNAPGTPAAA
460 470 480 490 500
PVGKNVPIMF ASVVRRTGDV NAEAGSDNGT QYGTGSQPLP VTIGLSLNNY
510 520 530 540 550
SSALTPGQFF VWQLNFASGF MEIGLNVDGY FYAGTGASTT LIDLTELIDI
560 570
RPVGPRPSTS TLVFNLGGAT SGFSYV
Length:576
Mass (Da):60,151
Last modified:November 1, 1996 - v1
Checksum:i44FFB9F3E2149E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96868 mRNA. Translation: CAA65611.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96868 mRNA. Translation: CAA65611.1 .

3D structure databases

ProteinModelPortali Q85433.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
InterProi IPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic."
    Capucci L., Fusi P., Lavazza A., Pacciarini M.L., Rossi C.
    J. Virol. 70:8614-8623(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCAPSD_RHDVR
AccessioniPrimary (citable) accession number: Q85433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Two differents RNAs lead the expression of the capsid protein. One arises from the cleavage of the polyprotein translated from the genomic RNA and the other from the translation of a subgenomic RNA derived from the (-)RNA template. Capsid protein expressed from the subgenomic mRNA is produced in much larger amounts than the cleaved one (By similarity).By similarity

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3