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Q85297 (DUSP_MYXVL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dual specificity protein phosphatase H1 homolog

EC=3.1.3.-
EC=3.1.3.48
Gene names
Ordered Locus Names:m069L
ORF Names:I1L
OrganismMyxoma virus (strain Lausanne) (MYXV) [Reference proteome]
Taxonomic identifier31530 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
Virus hostOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated STAT1 and blocking interferon (IFN)-stimulated innate immune responses By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Protein serine phosphate + H2O = protein serine + phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Virion By similarity. Host cytoplasm By similarity. Note: Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus By similarity.

Induction

Expressed in the late phase of the viral replicative cycle.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Probable dual specificity protein phosphatase H1 homolog
PRO_0000094871

Sites

Active site1101Phosphocysteine intermediate

Experimental info

Mutagenesis1101C → S: Complete loss of activity. Ref.1
Sequence conflict172 – 1787HKLKLFG → T in AAA66956. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q85297 [UniParc].

Last modified July 11, 2002. Version 2.
Checksum: 318C99B3400A885F

FASTA17820,627
        10         20         30         40         50         60 
MDKKSLYENV LLKSTGALPK ARVPTKMMRV TDYVYLGNYN DAKAAPTSGI GFKYILNLTT 

        70         80         90        100        110        120 
EKYTIKNSSI TIIHMPLVDD EYTDLTKYFD YATTFLSNCE DKHYPVLVHC MAGVNRSGAI 

       130        140        150        160        170 
IMAYLMSRKS KDIPAFMYFL YIYHSIREQR GAFLENPSFR RQIIEKYIIN EHKLKLFG 

« Hide

References

« Hide 'large scale' references
[1]"Myxoma virus and Shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability."
Mossman K., Ostergaard H., Upton C., McFadden G.
Virology 206:572-582(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, MUTAGENESIS OF CYS-110.
[2]"The complete DNA sequence of myxoma virus."
Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X., Macaulay C., Willer D.O., Evans D.H., McFadden G.
Virology 264:298-318(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L31960 Genomic DNA. Translation: AAA66956.1.
AF170726 Genomic DNA. Translation: AAF14957.1.
RefSeqNP_051783.1. NC_001132.2.

3D structure databases

ProteinModelPortalQ85297.
SMRQ85297. Positions 1-171.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID932088.

Phylogenomic databases

ProtClustDBCLSP2509785.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUSP_MYXVL
AccessionPrimary (citable) accession number: Q85297
Secondary accession number(s): Q9Q8N1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families