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Q84ZX5 (ALL1_ARTVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major pollen allergen Art v 1
Alternative name(s):
Defensin-like protein 1
Allergen=Art v 1
OrganismArtemisia vulgaris (Mugwort)
Taxonomic identifier4220 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeAnthemideaeArtemisiinaeArtemisia

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Domain

Contains several extensin-like repeats in the C-terminal section.

Post-translational modification

Around 76% of the prolines are hydroxylated.

O-glycosylated. O-linkage of 3 galactoses plus 9-16 or 21-23 arabinose residues attached on one or two hydroxyprolines. Ref.1

Allergenic properties

Causes an allergic reaction in human.

Miscellaneous

Post-translational modifications might be important in the formation of epitopes recognized by IgE antibodies.

Sequence similarities

In the N-terminal section; belongs to the DEFL family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.1
Chain25 – 132108Major pollen allergen Art v 1
PRO_0000007033

Regions

Region28 – 7750Defensin-like domain
Compositional bias81 – 12949Pro-rich

Amino acid modifications

Disulfide bond30 ↔ 77 By similarity
Disulfide bond41 ↔ 61 By similarity
Disulfide bond46 ↔ 71 By similarity
Disulfide bond50 ↔ 73 By similarity

Secondary structure

........... 132
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q84ZX5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 745249C89919F316

FASTA13213,404
        10         20         30         40         50         60 
MAKCSYVFCA VLLIFIVAIG EMEAAGSKLC EKTSKTYSGK CDNKKCDKKC IEWEKAQHGA 

        70         80         90        100        110        120 
CHKREAGKES CFCYFDCSKS PPGATPAPPG AAPPPAAGGS PSPPADGGSP PPPADGGSPP 

       130 
VDGGSPPPPS TH 

« Hide

References

[1]"Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain."
Himly M., Jahn-Schmid B., Dedic A., Kelemen P., Wopfner N., Altmann F., van Ree R., Briza P., Richter K., Ebner C., Ferreira F.
FASEB J. 17:106-108(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-39, CHARACTERIZATION, IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION.
Tissue: Pollen.
[2]"Optimization of codon usage is required for effective genetic immunization against Art v 1, the major allergen of mugwort pollen."
Bauer R., Himly M., Dedic A., Ferreira F., Thalhamer J., Hartl A.
Allergy 58:1003-1010(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF493943 mRNA. Translation: AAO24900.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KPYNMR-A25-132[»]
ProteinModelPortalQ84ZX5.
SMRQ84ZX5. Positions 31-77.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3102. Art v 1.0101.
753. Art v 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR008176. Gamma-thionin.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamPF00304. Gamma-thionin. 1 hit.
[Graphical view]
SMARTSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMSSF57095. SSF57095. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ84ZX5.

Entry information

Entry nameALL1_ARTVU
AccessionPrimary (citable) accession number: Q84ZX5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Allergens

Nomenclature of allergens and list of entries