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Protein

Major pollen allergen Art v 1

Gene
N/A
Organism
Artemisia vulgaris (Mugwort)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Art v 1
Alternative name(s):
Defensin-like protein 1
Allergen: Art v 1
OrganismiArtemisia vulgaris (Mugwort)
Taxonomic identifieri4220 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeAnthemideaeArtemisiinaeArtemisia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3102. Art v 1.0101.
753. Art v 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000703325 – 132Major pollen allergen Art v 1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 77By similarity
Disulfide bondi41 ↔ 61By similarity
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi50 ↔ 73By similarity

Post-translational modificationi

Around 76% of the prolines are hydroxylated.
O-glycosylated. O-linkage of 3 galactoses plus 9-16 or 21-23 arabinose residues attached on one or two hydroxyprolines.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 36Combined sources9
Helixi44 – 53Combined sources10
Beta strandi57 – 64Combined sources8
Turni65 – 67Combined sources3
Beta strandi68 – 79Combined sources12
Beta strandi89 – 91Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KPYNMR-A25-132[»]
ProteinModelPortaliQ84ZX5.
SMRiQ84ZX5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ84ZX5.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 77Defensin-like domainAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 129Pro-richAdd BLAST49

Domaini

Contains several extensin-like repeats in the C-terminal section.

Sequence similaritiesi

In the N-terminal section; belongs to the DEFL family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q84ZX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKCSYVFCA VLLIFIVAIG EMEAAGSKLC EKTSKTYSGK CDNKKCDKKC
60 70 80 90 100
IEWEKAQHGA CHKREAGKES CFCYFDCSKS PPGATPAPPG AAPPPAAGGS
110 120 130
PSPPADGGSP PPPADGGSPP VDGGSPPPPS TH
Length:132
Mass (Da):13,404
Last modified:June 1, 2003 - v1
Checksum:i745249C89919F316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493943 mRNA. Translation: AAO24900.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493943 mRNA. Translation: AAO24900.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KPYNMR-A25-132[»]
ProteinModelPortaliQ84ZX5.
SMRiQ84ZX5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3102. Art v 1.0101.
753. Art v 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ84ZX5.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALL1_ARTVU
AccessioniPrimary (citable) accession number: Q84ZX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Post-translational modifications might be important in the formation of epitopes recognized by IgE antibodies.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.