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Q84ZX5

- ALL1_ARTVU

UniProt

Q84ZX5 - ALL1_ARTVU

Protein

Major pollen allergen Art v 1

Gene
N/A
Organism
Artemisia vulgaris (Mugwort)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. defense response Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major pollen allergen Art v 1
    Alternative name(s):
    Defensin-like protein 1
    Allergen: Art v 1
    OrganismiArtemisia vulgaris (Mugwort)
    Taxonomic identifieri4220 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeAnthemideaeArtemisiinaeArtemisia

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3102. Art v 1.0101.
    753. Art v 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 132108Major pollen allergen Art v 1PRO_0000007033Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 77By similarity
    Disulfide bondi41 ↔ 61By similarity
    Disulfide bondi46 ↔ 71By similarity
    Disulfide bondi50 ↔ 73By similarity

    Post-translational modificationi

    Around 76% of the prolines are hydroxylated.
    O-glycosylated. O-linkage of 3 galactoses plus 9-16 or 21-23 arabinose residues attached on one or two hydroxyprolines.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    Secondary structure

    1
    132
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 369
    Helixi44 – 5310
    Beta strandi57 – 648
    Turni65 – 673
    Beta strandi68 – 7912
    Beta strandi89 – 913

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KPYNMR-A25-132[»]
    ProteinModelPortaliQ84ZX5.
    SMRiQ84ZX5. Positions 31-77.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ84ZX5.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni28 – 7750Defensin-like domainAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi81 – 12949Pro-richAdd
    BLAST

    Domaini

    Contains several extensin-like repeats in the C-terminal section.

    Sequence similaritiesi

    In the N-terminal section; belongs to the DEFL family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR008176. Gamma-thionin.
    IPR003614. Scorpion_toxin-like.
    [Graphical view]
    PfamiPF00304. Gamma-thionin. 1 hit.
    [Graphical view]
    SMARTiSM00505. Knot1. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q84ZX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKCSYVFCA VLLIFIVAIG EMEAAGSKLC EKTSKTYSGK CDNKKCDKKC    50
    IEWEKAQHGA CHKREAGKES CFCYFDCSKS PPGATPAPPG AAPPPAAGGS 100
    PSPPADGGSP PPPADGGSPP VDGGSPPPPS TH 132
    Length:132
    Mass (Da):13,404
    Last modified:June 1, 2003 - v1
    Checksum:i745249C89919F316
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF493943 mRNA. Translation: AAO24900.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF493943 mRNA. Translation: AAO24900.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KPY NMR - A 25-132 [» ]
    ProteinModelPortali Q84ZX5.
    SMRi Q84ZX5. Positions 31-77.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3102. Art v 1.0101.
    753. Art v 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q84ZX5.

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR008176. Gamma-thionin.
    IPR003614. Scorpion_toxin-like.
    [Graphical view ]
    Pfami PF00304. Gamma-thionin. 1 hit.
    [Graphical view ]
    SMARTi SM00505. Knot1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain."
      Himly M., Jahn-Schmid B., Dedic A., Kelemen P., Wopfner N., Altmann F., van Ree R., Briza P., Richter K., Ebner C., Ferreira F.
      FASEB J. 17:106-108(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-39, CHARACTERIZATION, IDENTIFICATION BY MASS SPECTROMETRY, GLYCOSYLATION.
      Tissue: Pollen.
    2. "Optimization of codon usage is required for effective genetic immunization against Art v 1, the major allergen of mugwort pollen."
      Bauer R., Himly M., Dedic A., Ferreira F., Thalhamer J., Hartl A.
      Allergy 58:1003-1010(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pollen.

    Entry informationi

    Entry nameiALL1_ARTVU
    AccessioniPrimary (citable) accession number: Q84ZX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Post-translational modifications might be important in the formation of epitopes recognized by IgE antibodies.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3