PAPP5

Functionⁱ

Isoform 2 dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms, and enhances phytochrome-mediated photoresponses, probably by enhancing their stability and their binding affinity for light signal transducers such as NDPK2. Can use para-nitrophenylphosphate (pNPP) as substrate.1 Publication

Catalytic activityⁱ

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Cofactorⁱ

Mn²⁺By similarityNote: Binds 2 manganese ions per subunit.By similarity

Enzyme regulationⁱ

Activated by arachidonic acid (AA).

Kineticsⁱ

Experiments have been done in the presence of 100 µM arachidonic acid (AA).

V_max=
22 µmol/min/mg enzyme with pNPP as substrate (at pH 7.5 and 30 degrees Celsius)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Phytochrome-specific type 5 phosphatase controls light signal flux by enhancing phytochrome stability and affinity for a signal transducer."
  Ryu J.S., Kim J.-I., Kunkel T., Kim B.C., Cho D.S., Hong S.H., Kim S.-H., Fernandez A.P., Kim Y., Alonso J.M., Ecker J.R., Nagy F., Lim P.O., Song P.-S., Schaefer E., Nam H.G.
  Cell 120:395-406(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, ACTIVATION BY ARACHIDONIC ACID, INTERACTION WITH PHYA AND PHYB.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	282	Manganese 1By similarity	1
Metal bindingⁱ	284	Manganese 1By similarity	1
Metal bindingⁱ	311	Manganese 1By similarity	1
Metal bindingⁱ	311	Manganese 2By similarity	1
Metal bindingⁱ	343	Manganese 2By similarity	1
Active siteⁱ	344	Proton donorBy similarity	1
Metal bindingⁱ	392	Manganese 2By similarity	1
Metal bindingⁱ	467	Manganese 2By similarity	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
phosphoprotein phosphatase activity
Source: TAIR
Inferred from direct assayⁱ
- 15707897
protein serine/threonine phosphatase activity
Source: TAIR
Inferred from sequence or structural similarityⁱ
- 12068129
tetrapyrrole binding
Source: TAIR
Inferred from direct assayⁱ
- 23555952

Complete GO annotation...

GO - Biological processⁱ

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-ATH-5675221. Negative regulation of MAPK pathway. R-ATH-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Reactomeⁱ

R-ATH-5675221. Negative regulation of MAPK pathway.
R-ATH-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein phosphatase 5 (EC:3.1.3.16)
Gene namesⁱ	Name:PAPP5 Synonyms:PP5 Ordered Locus Names:At2g42810 ORF Names:F7D19.19
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT2G42810.
TAIRⁱ	locus:2052345. AT2G42810.

Subcellular locationⁱ

Isoform 1 :

Endoplasmic reticulum membrane; Multi-pass membrane protein
Nucleus membrane By similarity; Multi-pass membrane protein By similarity

Isoform 2 :

Cytoplasm
Nucleus › nucleoplasm
Nucleus speckle

Note:

Cytoplasmic in darkness, but translocated to the nucleus upon illumination, when associated with phytochromes into speckles.

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	163 – 183	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	185 – 205	HelicalSequence analysisAdd BLAST		21

GO - Cellular componentⁱ

cytoplasm
Source: TAIR
Inferred from direct assayⁱ
- 12972652
- 15707897
cytosol
Source: TAIR
Inferred from direct assayⁱ
- 21166475
integral component of endoplasmic reticulum membrane
Source: TAIR
Inferred from direct assayⁱ
- 12972652
nuclear envelope
Source: TAIR
Inferred from direct assayⁱ
- 12972652
nuclear membrane Source: UniProtKB-SubCell
nuclear speck Source: UniProtKB-SubCell
nucleus
Source: TAIR
Inferred from direct assayⁱ
- 12972652
- 15707897
plasmodesma
Source: TAIR
Inferred from direct assayⁱ
- 21533090

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000308988	1 – 538	Serine/threonine-protein phosphatase 5Add BLAST		538

Proteomic databases

PaxDbⁱ	Q84XU2.
PRIDEⁱ	Q84XU2.

PTM databases

iPTMnetⁱ	Q84XU2.

iPTMnetⁱ

Q84XU2.

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	Q84XU2. baseline and differential.
Genevisibleⁱ	Q84XU2. AT.

Interactionⁱ

Subunit structureⁱ

Interacts with PHYA and PHYB, mostly when they are phosphorylated and in Pfr forms.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AGO1	D6RUV9	2	EBI-4445012,EBI-7498167	From Nicotiana tabacum.

With

Entry

#Exp.

IntAct

Notes

AGO1

D6RUV9

2

EBI-4445012,EBI-7498167

From Nicotiana tabacum.

Protein-protein interaction databases

BioGridⁱ	4218. 3 interactors.
IntActⁱ	Q84XU2. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8375614.
STRINGⁱ	3702.AT2G42810.2.

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5JJT	X-ray	2.10	A/B	5-537	[»]
ProteinModelPortalⁱ	Q84XU2.
SMRⁱ	Q84XU2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	13 – 46	TPR 1Add BLAST	34
Repeatⁱ	48 – 80	TPR 2Add BLAST	33
Repeatⁱ	81 – 114	TPR 3Add BLAST	34

Domainⁱ

TPR repeats are required for the binding with phytochromes.

Sequence similaritiesⁱ

Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.Curated

Keywords - Domainⁱ

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0376. Eukaryota. COG0639. LUCA.
HOGENOMⁱ	HOG000172698.
InParanoidⁱ	Q84XU2.
KEGG Orthology (KO) More...KOⁱ	K04460.
OMAⁱ	AHMSLGK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG0936077E.
PhylomeDBⁱ	Q84XU2.

Family and domain databases

Gene3Dⁱ	1.25.40.10. 1 hit. 3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR013235. PPP_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. IPR011236. Ser/Thr_PPase_5. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom. IPR001440. TPR_1. IPR019734. TPR_repeat.
PANTHERⁱ	PTHR11668:SF326. PTHR11668:SF326. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit. PF08321. PPP5. 1 hit. PF00515. TPR_1. 1 hit.
PRINTSⁱ	PR00114. STPHPHTASE.
SMARTⁱ	View protein in SMART SM00156. PP2Ac. 1 hit. SM00028. TPR. 3 hits.
SUPFAMⁱ	SSF48452. SSF48452. 1 hit. SSF56300. SSF56300. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q84XU2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METKNENSDV SRAEEFKSQA NEAFKGHKYS SAIDLYTKAI ELNSNNAVYW 
        60         70         80         90        100
ANRAFAHTKL EEYGSAIQDA SKAIEVDSRY SKGYYRRGAA YLAMGKFKDA 
       110        120        130        140        150
LKDFQQVKRL SPNDPDATRK LKECEKAVMK LKFEEAISVP VSERRSVAES 
       160        170        180        190        200
IDFHTIGNKP RSSSMPTKTA LAAVVAAVMV VAVRGFATTE ILMVLVSVVL 
       210        220        230        240        250
GTFWWGSFSG KVEPQYSGAR IEGEEVTLDF VKTMMEDFKN QKTLHKRYAY 
       260        270        280        290        300
QIVLQTRQIL LALPSLVDIS VPHGKHITVC GDVHGQFYDL LNIFELNGLP 
       310        320        330        340        350
SEENPYLFNG DFVDRGSFSV EIILTLFAFK CMCPSSIYLA RGNHESKSMN 
       360        370        380        390        400
KIYGFEGEVR SKLSEKFVDL FAEVFCYLPL AHVINGKVFV VHGGLFSVDG 
       410        420        430        440        450
VKLSDIRAID RFCEPPEEGL MCELLWSDPQ PLPGRGPSKR GVGLSFGGDV 
       460        470        480        490        500
TKRFLQDNNL DLLVRSHEVK DEGYEVEHDG KLITVFSAPN YCDQMGNKGA 
       510        520        530 
FIRFEAPDMK PNIVTFSAVP HPDVKPMAYA NNFLRMFN

Length:538

Mass (Da):60,283

Last modified:June 1, 2003 - v1

Checksum:ⁱ93ECC937F02D3541

GO

Isoform 2 (identifier: Q84XU2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
157-211: GNKPRSSSMPTKTALAAVVAAVMVVAVRGFATTEILMVLVSVVLGTFWWGSFSGK → E

« Hide

        10         20         30         40         50
METKNENSDV SRAEEFKSQA NEAFKGHKYS SAIDLYTKAI ELNSNNAVYW 
        60         70         80         90        100
ANRAFAHTKL EEYGSAIQDA SKAIEVDSRY SKGYYRRGAA YLAMGKFKDA 
       110        120        130        140        150
LKDFQQVKRL SPNDPDATRK LKECEKAVMK LKFEEAISVP VSERRSVAES 
       160        170        180        190        200
IDFHTIEVEP QYSGARIEGE EVTLDFVKTM MEDFKNQKTL HKRYAYQIVL 
       210        220        230        240        250
QTRQILLALP SLVDISVPHG KHITVCGDVH GQFYDLLNIF ELNGLPSEEN 
       260        270        280        290        300
PYLFNGDFVD RGSFSVEIIL TLFAFKCMCP SSIYLARGNH ESKSMNKIYG 
       310        320        330        340        350
FEGEVRSKLS EKFVDLFAEV FCYLPLAHVI NGKVFVVHGG LFSVDGVKLS 
       360        370        380        390        400
DIRAIDRFCE PPEEGLMCEL LWSDPQPLPG RGPSKRGVGL SFGGDVTKRF 
       410        420        430        440        450
LQDNNLDLLV RSHEVKDEGY EVEHDGKLIT VFSAPNYCDQ MGNKGAFIRF 
       460        470        480 
EAPDMKPNIV TFSAVPHPDV KPMAYANNFL RMFN

Note: Partial isoform 2 lacking TPR repeats exhibits enhanced activity at pH 7.5 with pNPP as substrate. This partial protein is in addition inhibited by okadaic acid.

Show »

Length:484

Mass (Da):54,702

Checksum:ⁱ04780D6007B69EF8

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_029087	157 – 211	GNKPR…SFSGK → E in isoform 2. 2 PublicationsAdd BLAST		55

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY182779 mRNA. Translation: AAO26216.1. AC006931 Genomic DNA. Translation: AAD21727.2. CP002685 Genomic DNA. Translation: AEC10171.1. CP002685 Genomic DNA. Translation: AEC10172.1. CP002685 Genomic DNA. Translation: ANM61627.1. CP002685 Genomic DNA. Translation: ANM61628.1. AF419574 mRNA. Translation: AAL31906.1. AY080674 mRNA. Translation: AAL86350.1. BT010180 mRNA. Translation: AAQ22649.1. AK221789 mRNA. Translation: BAD93924.1.
PIRⁱ	E84858.
NCBI Reference Sequences More...RefSeqⁱ	NP_001031534.1. NM_001036457.3. [Q84XU2-1] NP_001323832.1. NM_001336995.1. [Q84XU2-2] NP_001323833.1. NM_001336996.1. [Q84XU2-2] NP_565985.1. NM_129842.4. [Q84XU2-2]
UniGeneⁱ	At.23737.

Genome annotation databases

EnsemblPlantsⁱ	AT2G42810.2; AT2G42810.2; AT2G42810. [Q84XU2-1]
GeneIDⁱ	818881.
Grameneⁱ	AT2G42810.2; AT2G42810.2; AT2G42810. [Q84XU2-1]
KEGGⁱ	ath:AT2G42810.

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY182779 mRNA. Translation: AAO26216.1. AC006931 Genomic DNA. Translation: AAD21727.2. CP002685 Genomic DNA. Translation: AEC10171.1. CP002685 Genomic DNA. Translation: AEC10172.1. CP002685 Genomic DNA. Translation: ANM61627.1. CP002685 Genomic DNA. Translation: ANM61628.1. AF419574 mRNA. Translation: AAL31906.1. AY080674 mRNA. Translation: AAL86350.1. BT010180 mRNA. Translation: AAQ22649.1. AK221789 mRNA. Translation: BAD93924.1.
PIRⁱ	E84858.
NCBI Reference Sequences More...RefSeqⁱ	NP_001031534.1. NM_001036457.3. [Q84XU2-1] NP_001323832.1. NM_001336995.1. [Q84XU2-2] NP_001323833.1. NM_001336996.1. [Q84XU2-2] NP_565985.1. NM_129842.4. [Q84XU2-2]
UniGeneⁱ	At.23737.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5JJT	X-ray	2.10	A/B	5-537	[»]
ProteinModelPortalⁱ	Q84XU2.
SMRⁱ	Q84XU2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4218. 3 interactors.
IntActⁱ	Q84XU2. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8375614.
STRINGⁱ	3702.AT2G42810.2.

PTM databases

iPTMnetⁱ	Q84XU2.

iPTMnetⁱ

Q84XU2.

Proteomic databases

PaxDbⁱ	Q84XU2.
PRIDEⁱ	Q84XU2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	AT2G42810.2; AT2G42810.2; AT2G42810. [Q84XU2-1]
GeneIDⁱ	818881.
Grameneⁱ	AT2G42810.2; AT2G42810.2; AT2G42810. [Q84XU2-1]
KEGGⁱ	ath:AT2G42810.

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT2G42810.
TAIRⁱ	locus:2052345. AT2G42810.

Phylogenomic databases

eggNOGⁱ	KOG0376. Eukaryota. COG0639. LUCA.
HOGENOMⁱ	HOG000172698.
InParanoidⁱ	Q84XU2.
KEGG Orthology (KO) More...KOⁱ	K04460.
OMAⁱ	AHMSLGK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG0936077E.
PhylomeDBⁱ	Q84XU2.

Enzyme and pathway databases

Reactomeⁱ	R-ATH-5675221. Negative regulation of MAPK pathway. R-ATH-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Reactomeⁱ

R-ATH-5675221. Negative regulation of MAPK pathway.
R-ATH-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q84XU2.

PROⁱ

PR:Q84XU2.

Gene expression databases

ExpressionAtlasⁱ	Q84XU2. baseline and differential.
Genevisibleⁱ	Q84XU2. AT.

Family and domain databases

Gene3Dⁱ	1.25.40.10. 1 hit. 3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR013235. PPP_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. IPR011236. Ser/Thr_PPase_5. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical_dom. IPR001440. TPR_1. IPR019734. TPR_repeat.
PANTHERⁱ	PTHR11668:SF326. PTHR11668:SF326. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit. PF08321. PPP5. 1 hit. PF00515. TPR_1. 1 hit.
PRINTSⁱ	PR00114. STPHPHTASE.
SMARTⁱ	View protein in SMART SM00156. PP2Ac. 1 hit. SM00028. TPR. 3 hits.
SUPFAMⁱ	SSF48452. SSF48452. 1 hit. SSF56300. SSF56300. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPP5_ARATH
Accessionⁱ	Q84XU2Primary (citable) accession number: Q84XU2 Secondary accession number(s): Q56X87 , Q8RXU0, Q8W581, Q9SJH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	June 1, 2003
	Last modified:	July 5, 2017
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - Q84XU2 (PPP5_ARATH)

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Serine/threonine-protein phosphatase 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Enzyme regulationⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ