Q84WW6 (ASHH1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase ASHH1
EC=2.1.1.43

Alternative name(s):
ASH1 homolog 1
Protein SET DOMAIN GROUP 26

Gene names

Name:	ASHH1
Synonyms:	SDG26, SET26
Ordered Locus Names:	At1g76710
ORF Names:	F28O16.8

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome › centromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 1 AWS domain. Contains 1 post-SET domain. Contains 1 SET domain.
Sequence caution	The sequence AAF04434.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Centromere Chromosome Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	vegetative to reproductive phase transition of meristem Inferred from mutant phenotype. Source: TAIR
Cellular component	chromosome, centromeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: TAIR
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Histone-lysine N-methyltransferase ASHH1		PRO_0000233370
Regions
	Domain	36 – 87	52	AWS
	Domain	88 – 210	123	SET
	Domain	213 – 229	17	Post-SET

Sequences

	Sequence		Length	Mass (Da)
	Q84WW6 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 87795D3EAAB01C5D	FASTA	492	55,285
	10 20 30 40 50 60 MQFSCDPDQE GDELPQYEHI YQNDFSYRKH KKQKEEDISI CECKFDFGDP DSACGERCLN 70 80 90 100 110 120 VITNTECTPG YCPCGVYCKN QKFQKCEYAK TKLIKCEGRG WGLVALEEIK AGQFIMEYCG 130 140 150 160 170 180 EVISWKEAKK RAQTYETHGV KDAYIISLNA SEAIDATKKG SLARFINHSC RPNCETRKWN 190 200 210 220 230 240 VLGEVRVGIF AKESISPRTE LAYDYNFEWY GGAKVRCLCG AVACSGFLGA KSRGFQEDTY 250 260 270 280 290 300 VWEDGDDRYS VDKIPVYDSA EDELTSEPSK NGESNTNEEK EKDISTENHL ESTALNIQQQ 310 320 330 340 350 360 SDSTPTPMEE DVVTETVKTE TSEDMKLLSQ NSQEDSSPKT AIVSRVHGNI SKIKSESLPK 370 380 390 400 410 420 KRGRPFSGGK TKNVAQKHVD IANVVQLLAT KEAQDEVLKY EEVKKEAAVR LSSLYDEIRP 430 440 450 460 470 480 AIEEHERDSQ DSVATSVAEK WIQASCNKLK AEFDLYSSVI KNIASTPIKP QDTKTKVAEA 490 GNEDHIKLLE AK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-311, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010718 Genomic DNA. Translation: AAF04434.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE35879.1. CP002684 Genomic DNA. Translation: AEE35880.1. BT001913 mRNA. Translation: AAN71912.1. AF408059 mRNA. Translation: AAL01110.1.
IPI	IPI00530898.
PIR	E96795.
RefSeq	NP_177797.2. NM_106321.3. NP_974158.1. NM_202429.1.
UniGene	At.70058.
3D structure databases
ProteinModelPortal	Q84WW6.
SMR	Q84WW6. Positions 11-229.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q84WW6. 1 interaction.
Proteomic databases
PRIDE	Q84WW6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G76710.1; AT1G76710.1; AT1G76710. AT1G76710.2; AT1G76710.2; AT1G76710.
GeneID	844005.
GenomeReviews	Gene locus AT1G76710 in contig CT485782_GR.
KEGG	ath:AT1G76710.
NMPDR	fig|3702.1.peg.7199.
Organism-specific databases
TAIR	At1g76710.
Phylogenomic databases
eggNOG	KOG4442.
GeneTree	EPGT00070000028802.
HOGENOM	HBG320543.
InParanoid	Q84WW6.
OMA	EVISWKE.
PhylomeDB	Q84WW6.
ProtClustDB	CLSN2690500.
Gene expression databases
ArrayExpress	Q84WW6.
Genevestigator	Q84WW6.
GermOnline	AT1G76710. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR006560. AWS. IPR003616. Post-SET_dom. IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASHH1_ARATH

Accession

Primary (citable) accession number: Q84WW6
Secondary accession number(s): Q945S9, Q9SRE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program