Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable 6-phosphogluconolactonase 5, chloroplastic

Gene

EMB2024

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 3, chloroplastic (At1g24280), Glucose-6-phosphate 1-dehydrogenase 1, chloroplastic (APG1), Glucose-6-phosphate 1-dehydrogenase (At3g27300), Glucose-6-phosphate 1-dehydrogenase (AXX17_At3g29760), Glucose-6-phosphate 1-dehydrogenase (G6PD4), Glucose-6-phosphate 1-dehydrogenase 2, chloroplastic (At5g13110), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g25530), Glucose-6-phosphate 1-dehydrogenase (At5g35790), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g33080), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g12520), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase (G6PD5), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 2 (ACG12), Glucose-6-phosphate 1-dehydrogenase (At1g09420), Glucose-6-phosphate 1-dehydrogenase (AXX17_At5g38480), Glucose-6-phosphate 1-dehydrogenase (AXX17_At1g09330), Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (ACG9), Glucose-6-phosphate 1-dehydrogenase (At5g40760), Glucose-6-phosphate 1-dehydrogenase 4, chloroplastic (At1g09420)
  2. Probable 6-phosphogluconolactonase 5, chloroplastic (EMB2024), Probable 6-phosphogluconolactonase 3 (At5g24420), Probable 6-phosphogluconolactonase 4 (At5g24410), Probable 6-phosphogluconolactonase 1 (At1g13700), Probable 6-phosphogluconolactonase 2 (At3g49360)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At5g39410), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At3g01580), 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (At5g41670), 6-phosphogluconate dehydrogenase, decarboxylating 3 (At3g02360), 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic (At1g64190), 6-phosphogluconate dehydrogenase, decarboxylating (AXX17_At1g57660)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: TAIR

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • cellular response to redox state Source: TAIR
  • defense response to bacterium Source: TAIR
  • defense response to oomycetes Source: TAIR
  • nitrate assimilation Source: TAIR
  • pentose-phosphate shunt, oxidative branch Source: GO_Central

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciARA:AT5G24400-MONOMER
BRENDAi3.1.1.31 399
ReactomeiR-ATH-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase 5, chloroplastic (EC:3.1.1.31)
Short name:
6PGL 5
Alternative name(s):
Protein EMBRYO DEFECTIVE 2024
Gene namesi
Name:EMB2024
Ordered Locus Names:At5g24400
ORF Names:K16H17.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G24400
TAIRilocus:2152906 AT5G24400

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Peroxisome, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 68ChloroplastSequence analysisAdd BLAST68
ChainiPRO_000028867269 – 325Probable 6-phosphogluconolactonase 5, chloroplasticAdd BLAST257

Proteomic databases

PaxDbiQ84WW2
PRIDEiQ84WW2

PTM databases

iPTMnetiQ84WW2

Expressioni

Gene expression databases

ExpressionAtlasiQ84WW2 baseline and differential
GenevisibleiQ84WW2 AT

Interactioni

Protein-protein interaction databases

BioGridi17786, 1 interactor
STRINGi3702.AT5G24400.1

Structurei

3D structure databases

ProteinModelPortaliQ84WW2
SMRiQ84WW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3147 Eukaryota
COG0363 LUCA
HOGENOMiHOG000256285
InParanoidiQ84WW2
KOiK01057
OMAiKQPHLAI
OrthoDBiEOG09360PR9
PhylomeDBiQ84WW2

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q84WW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSCFLRS ILFSSPTNLR SNHHLPTFFP KNYLICSHST SSRFESLSVS
60 70 80 90 100
SIGTGSTKKS SDTRRKVKSM ATTNIGKEEK KRVEIYDLEE NLVIDLAKFT
110 120 130 140 150
ADLSDKFCKE RGAFTVVVSG GSLIKSLRKL VESPYVDSID WARWHFFWVD
160 170 180 190 200
ERVVPKNHDD SNYKLAYDSF LSKVPIPPGN VYAINEALSA EAAADDYETC
210 220 230 240 250
LKHLVNTNIL RVSESTGFPK FDLMLLGMGP DGHVASLFPG HGLCNESKKW
260 270 280 290 300
VVSISDSPKP PSERITFTFP VINSSAHVAL VVCGSGKAEA VEAALKKTGN
310 320
VPPAGSVSAE DELVWFLDKP ASSKL
Length:325
Mass (Da):35,645
Last modified:June 1, 2003 - v1
Checksum:i0FBC6E95F9C073DC
GO

Sequence cautioni

The sequence BAB11233 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30P → L in AAM63366 (Ref. 4) Curated1
Sequence conflicti33Y → H in AAM63366 (Ref. 4) Curated1
Sequence conflicti93 – 94VI → AV in AAM63366 (Ref. 4) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016884 Genomic DNA Translation: BAB11233.1 Different initiation.
CP002688 Genomic DNA Translation: AED93307.1
BT001923 mRNA Translation: AAN71922.1
AY086161 mRNA Translation: AAM63366.1
Z26557 mRNA Translation: CAA81328.1
RefSeqiNP_568445.1, NM_122348.3
UniGeneiAt.19070

Genome annotation databases

EnsemblPlantsiAT5G24400.1; AT5G24400.1; AT5G24400
GeneIDi832511
GrameneiAT5G24400.1; AT5G24400.1; AT5G24400
KEGGiath:AT5G24400

Similar proteinsi

Entry informationi

Entry namei6PGL5_ARATH
AccessioniPrimary (citable) accession number: Q84WW2
Secondary accession number(s): Q42135, Q8LD77, Q9FIN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health