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Protein

Nicotinate phosphoribosyltransferase 2

Gene

NAPRT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).1 Publication
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.Curated

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase 1 (NAPRT1), Nicotinate phosphoribosyltransferase 2 (NAPRT2)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Ligase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciARA:AT2G23420-MONOMER
ReactomeiR-ATH-197264 Nicotinamide salvaging
R-ATH-6798695 Neutrophil degranulation
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase 21 Publication (EC:6.3.4.21Curated)
Gene namesi
Name:NAPRT21 Publication
Ordered Locus Names:At2g23420Imported
ORF Names:F26B6.7Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G23420
TAIRilocus:2046872 AT2G23420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004322181 – 557Nicotinate phosphoribosyltransferase 2Add BLAST557

Proteomic databases

PaxDbiQ84WV8
PRIDEiQ84WV8

PTM databases

iPTMnetiQ84WV8

Expressioni

Inductioni

Up-regulated in the quinolinate synthase mutant old5 causing increased NAD steady state levels.1 Publication

Gene expression databases

ExpressionAtlasiQ84WV8 baseline and differential
GenevisibleiQ84WV8 AT

Interactioni

Protein-protein interaction databases

IntActiQ84WV8, 37 interactors
STRINGi3702.AT2G23420.1

Structurei

3D structure databases

ProteinModelPortaliQ84WV8
SMRiQ84WV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiKOG2511 Eukaryota
COG1488 LUCA
HOGENOMiHOG000001111
KOiK00763
OMAiNPHIYKV
OrthoDBiEOG0936059W
PhylomeDBiQ84WV8

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR007229 Nic_PRibTrfase-Fam
IPR006405 Nic_PRibTrfase_pncB
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 2 hits
TIGRFAMsiTIGR01513 NAPRTase_put, 1 hit

Sequencei

Sequence statusi: Complete.

Q84WV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPKENGSEL GQKIIDGPTN PMVTPLLNDL YQFTMAYAYW KAGKHNERSV
60 70 80 90 100
FDLYFRKNPF GGEYTVFAGL EECVKFLANF KLTDEEIDFV QECLPGSEEA
110 120 130 140 150
FCDYLRGLDC SDVEVYAIPE GSVVFPKVPL MRVEGPVGVV QLLETPFLNL
160 170 180 190 200
VNFASLVATN AARHRFVAGK SKSLLEFGAR RAQGPDGAIS ASKYCYLGGF
210 220 230 240 250
DATSNVAAGK LFGIPLRGTH SHAYVSSFMS TDEIVDKVLR SADGKTTCED
260 270 280 290 300
FVSHVQTWLK KIQYSPSLSG IFSETNQSEL AAFTSYALAF PKTFLALVDT
310 320 330 340 350
YDVMKSGIPN FCAVALALND FGYKALGIRL DSGDLAYLSR EARNFFCTVE
360 370 380 390 400
RELKVPGFGK MVVTASNDLN EETIDALNKQ GHEVDAFGIG TYLVTCYSQA
410 420 430 440 450
ALGCVFKLVE INNQPRIKLS EDVTKVSIPC KKRSYRLYGK EGYPLVDIMT
460 470 480 490 500
GENEPPPKVG ERLLCRHPFN ESKRAYVVPQ RVEELLKCYW RGSADEAREV
510 520 530 540 550
LPPLKEIRDR CIKQLENMRP DHMRRLNPTP YKVSVSAKLY DFIHFLWLNE

APVGELQ
Length:557
Mass (Da):62,273
Last modified:June 1, 2003 - v1
Checksum:iF3F46DE14F3157F2
GO

Sequence cautioni

The sequence AAC23757 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003040 Genomic DNA Translation: AAC23757.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC07453.1
BT001932 mRNA Translation: AAN71931.1
PIRiT01131
RefSeqiNP_179923.2, NM_127906.6
UniGeneiAt.24789

Genome annotation databases

EnsemblPlantsiAT2G23420.1; AT2G23420.1; AT2G23420
GeneIDi816874
GrameneiAT2G23420.1; AT2G23420.1; AT2G23420
KEGGiath:AT2G23420

Similar proteinsi

Entry informationi

Entry nameiNPRT2_ARATH
AccessioniPrimary (citable) accession number: Q84WV8
Secondary accession number(s): O80459
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health