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Protein

Nicotinate phosphoribosyltransferase 2

Gene

NAPRT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).1 Publication
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.Curated

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase 1 (NAPRT1), Nicotinate phosphoribosyltransferase 2 (NAPRT2)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciARA:AT2G23420-MONOMER.
ReactomeiR-ATH-197264. Nicotinamide salvaging.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase 21 Publication (EC:6.3.4.21Curated)
Gene namesi
Name:NAPRT21 Publication
Ordered Locus Names:At2g23420Imported
ORF Names:F26B6.7Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G23420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Nicotinate phosphoribosyltransferase 2PRO_0000432218Add
BLAST

Proteomic databases

PaxDbiQ84WV8.
PRIDEiQ84WV8.

PTM databases

iPTMnetiQ84WV8.

Expressioni

Inductioni

Up-regulated in the quinolinate synthase mutant old5 causing increased NAD steady state levels.1 Publication

Gene expression databases

GenevisibleiQ84WV8. AT.

Interactioni

Protein-protein interaction databases

IntActiQ84WV8. 37 interactions.
STRINGi3702.AT2G23420.1.

Structurei

3D structure databases

ProteinModelPortaliQ84WV8.
SMRiQ84WV8. Positions 26-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiKOG2511. Eukaryota.
COG1488. LUCA.
HOGENOMiHOG000001111.
KOiK00763.
OMAiDNNTHTA.
PhylomeDBiQ84WV8.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q84WV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPKENGSEL GQKIIDGPTN PMVTPLLNDL YQFTMAYAYW KAGKHNERSV
60 70 80 90 100
FDLYFRKNPF GGEYTVFAGL EECVKFLANF KLTDEEIDFV QECLPGSEEA
110 120 130 140 150
FCDYLRGLDC SDVEVYAIPE GSVVFPKVPL MRVEGPVGVV QLLETPFLNL
160 170 180 190 200
VNFASLVATN AARHRFVAGK SKSLLEFGAR RAQGPDGAIS ASKYCYLGGF
210 220 230 240 250
DATSNVAAGK LFGIPLRGTH SHAYVSSFMS TDEIVDKVLR SADGKTTCED
260 270 280 290 300
FVSHVQTWLK KIQYSPSLSG IFSETNQSEL AAFTSYALAF PKTFLALVDT
310 320 330 340 350
YDVMKSGIPN FCAVALALND FGYKALGIRL DSGDLAYLSR EARNFFCTVE
360 370 380 390 400
RELKVPGFGK MVVTASNDLN EETIDALNKQ GHEVDAFGIG TYLVTCYSQA
410 420 430 440 450
ALGCVFKLVE INNQPRIKLS EDVTKVSIPC KKRSYRLYGK EGYPLVDIMT
460 470 480 490 500
GENEPPPKVG ERLLCRHPFN ESKRAYVVPQ RVEELLKCYW RGSADEAREV
510 520 530 540 550
LPPLKEIRDR CIKQLENMRP DHMRRLNPTP YKVSVSAKLY DFIHFLWLNE

APVGELQ
Length:557
Mass (Da):62,273
Last modified:June 1, 2003 - v1
Checksum:iF3F46DE14F3157F2
GO

Sequence cautioni

The sequence AAC23757.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003040 Genomic DNA. Translation: AAC23757.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC07453.1.
BT001932 mRNA. Translation: AAN71931.1.
PIRiT01131.
RefSeqiNP_179923.2. NM_127906.5.
UniGeneiAt.24789.

Genome annotation databases

EnsemblPlantsiAT2G23420.1; AT2G23420.1; AT2G23420.
GeneIDi816874.
GrameneiAT2G23420.1; AT2G23420.1; AT2G23420.
KEGGiath:AT2G23420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003040 Genomic DNA. Translation: AAC23757.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC07453.1.
BT001932 mRNA. Translation: AAN71931.1.
PIRiT01131.
RefSeqiNP_179923.2. NM_127906.5.
UniGeneiAt.24789.

3D structure databases

ProteinModelPortaliQ84WV8.
SMRiQ84WV8. Positions 26-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ84WV8. 37 interactions.
STRINGi3702.AT2G23420.1.

PTM databases

iPTMnetiQ84WV8.

Proteomic databases

PaxDbiQ84WV8.
PRIDEiQ84WV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G23420.1; AT2G23420.1; AT2G23420.
GeneIDi816874.
GrameneiAT2G23420.1; AT2G23420.1; AT2G23420.
KEGGiath:AT2G23420.

Organism-specific databases

TAIRiAT2G23420.

Phylogenomic databases

eggNOGiKOG2511. Eukaryota.
COG1488. LUCA.
HOGENOMiHOG000001111.
KOiK00763.
OMAiDNNTHTA.
PhylomeDBiQ84WV8.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
BioCyciARA:AT2G23420-MONOMER.
ReactomeiR-ATH-197264. Nicotinamide salvaging.

Miscellaneous databases

PROiQ84WV8.

Gene expression databases

GenevisibleiQ84WV8. AT.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "The Arabidopsis onset of leaf death5 mutation of quinolinate synthase affects nicotinamide adenine dinucleotide biosynthesis and causes early ageing."
    Schippers J.H., Nunes-Nesi A., Apetrei R., Hille J., Fernie A.R., Dijkwel P.P.
    Plant Cell 20:2909-2925(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, INDUCTION.

Entry informationi

Entry nameiNPRT2_ARATH
AccessioniPrimary (citable) accession number: Q84WV8
Secondary accession number(s): O80459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.