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Protein

ATP-dependent zinc metalloprotease FTSH 3, mitochondrial

Gene

FTSH3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi586Zinc; catalyticBy similarity1
Active sitei587By similarity1
Metal bindingi590Zinc; catalyticBy similarity1
Metal bindingi662Zinc; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi362 – 369ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B20. 399.

Protein family/group databases

MEROPSiM41.022.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FTSH 3, mitochondrial (EC:3.4.24.-)
Short name:
AtFTSH3
Gene namesi
Name:FTSH3
Ordered Locus Names:At2g29080
ORF Names:T9I4.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G29080.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • chloroplast thylakoid membrane Source: TAIR
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 83MitochondrionSequence analysisAdd BLAST83
ChainiPRO_000034132984 – 809ATP-dependent zinc metalloprotease FTSH 3, mitochondrialAdd BLAST726

Proteomic databases

PaxDbiQ84WU8.
PRIDEiQ84WU8.

PTM databases

SwissPalmiQ84WU8.

Expressioni

Inductioni

By heat and high light.1 Publication

Gene expression databases

GenevisibleiQ84WU8. AT.

Interactioni

Protein-protein interaction databases

BioGridi2806. 3 interactors.
STRINGi3702.AT2G29080.1.

Structurei

3D structure databases

ProteinModelPortaliQ84WU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi270 – 273Poly-Leu4
Compositional biasi274 – 304Gly-richAdd BLAST31

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
HOGENOMiHOG000217277.
InParanoidiQ84WU8.
KOiK08956.
OMAiMAHFESA.
OrthoDBiEOG093603BD.
PhylomeDBiQ84WU8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q84WU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMIFFSKLN RSISRSKGFL YGGGVRSAAR LLTSPGLEAA SVNEVEGGLG
60 70 80 90 100
FIRRHFASLA SRKGLVNNDL IGVFANPRLR RFFSDEAPKK KNYENYFPKD
110 120 130 140 150
KQEPKSDQKS EHKEGSEKNE NENVGDMFMN RFQNLLIPLL ALAVFFSTFS
160 170 180 190 200
FGSGEQQQIS FQEFKNKLLE PGLVDHIDVS NKSVAKVYVR STPKDQQTTD
210 220 230 240 250
VVHGNGNGIP AKRTGGQYKY YFNIGSVDSF EEKLEEAQEA LGVDRHEYVP
260 270 280 290 300
VTYVSEMVWY QEFMRFAPTL LLLGTLIYGA RRMQGGLGVG GTGGKNGRGI
310 320 330 340 350
FNIGKATITR ADKHSKNKIY FKDVAGCDEA KQEIMEFVHF LKNPKKYEDL
360 370 380 390 400
GAKIPKGALL VGPPGTGKTL LAKATAGESG VPFLSISGSD FMEMFVGVGP
410 420 430 440 450
SRVRHLFQEA RQAAPSIIFI DEIDAIGRAR GRGGLGGNDE RESTLNQLLV
460 470 480 490 500
EMDGFGTTAG VVVLAGTNRP DILDKALLRP GRFDRQITID KPDIKGRDQI
510 520 530 540 550
FKIYLKKIKL DHEPSYYSQR LAALTPGFAG ADIANVCNEA ALIAARHEGA
560 570 580 590 600
TVTMAHFESA IDRVIGGLEK KNRVISKLER RTVAYHESGH AVVGWFLEHA
610 620 630 640 650
EPLLKVTIVP RGTAALGFAQ YVPNENLLMT KEQLFDMTCM TLGGRAAEQV
660 670 680 690 700
LIGKISTGAQ NDLEKVTKMT YAQVAVYGFS DKVGLLSFPP RDDGYDFSKP
710 720 730 740 750
YSNKTGAIID EEVRDWVAKA YERTVELVEE HKVKVAEIAE LLLEKEVLHQ
760 770 780 790 800
DDLLKILGER PFKSAEVTNY DRFKSGFEET EKDSAATPTV EPVVDDGAPP

PFEPQVVPT
Length:809
Mass (Da):89,353
Last modified:June 1, 2003 - v1
Checksum:i2A54BBC8F8786429
GO

Sequence cautioni

The sequence AAC33234 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155E → D in AAL36270 (PubMed:14593172).Curated1
Sequence conflicti613T → A in BAE98430 (Ref. 4) Curated1
Sequence conflicti647A → P in AAL36270 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005315 Genomic DNA. Translation: AAC33234.1. Different initiation.
CP002685 Genomic DNA. Translation: AEC08208.1.
BT002743 mRNA. Translation: AAO22572.1.
AY063914 mRNA. Translation: AAL36270.1.
AK226271 mRNA. Translation: BAE98430.1.
PIRiT02738.
RefSeqiNP_850129.1. NM_179798.2.
UniGeneiAt.24335.

Genome annotation databases

EnsemblPlantsiAT2G29080.1; AT2G29080.1; AT2G29080.
GeneIDi817456.
GrameneiAT2G29080.1; AT2G29080.1; AT2G29080.
KEGGiath:AT2G29080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005315 Genomic DNA. Translation: AAC33234.1. Different initiation.
CP002685 Genomic DNA. Translation: AEC08208.1.
BT002743 mRNA. Translation: AAO22572.1.
AY063914 mRNA. Translation: AAL36270.1.
AK226271 mRNA. Translation: BAE98430.1.
PIRiT02738.
RefSeqiNP_850129.1. NM_179798.2.
UniGeneiAt.24335.

3D structure databases

ProteinModelPortaliQ84WU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2806. 3 interactors.
STRINGi3702.AT2G29080.1.

Protein family/group databases

MEROPSiM41.022.

PTM databases

SwissPalmiQ84WU8.

Proteomic databases

PaxDbiQ84WU8.
PRIDEiQ84WU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G29080.1; AT2G29080.1; AT2G29080.
GeneIDi817456.
GrameneiAT2G29080.1; AT2G29080.1; AT2G29080.
KEGGiath:AT2G29080.

Organism-specific databases

TAIRiAT2G29080.

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
HOGENOMiHOG000217277.
InParanoidiQ84WU8.
KOiK08956.
OMAiMAHFESA.
OrthoDBiEOG093603BD.
PhylomeDBiQ84WU8.

Enzyme and pathway databases

BRENDAi3.4.24.B20. 399.

Miscellaneous databases

PROiQ84WU8.

Gene expression databases

GenevisibleiQ84WU8. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSH3_ARATH
AccessioniPrimary (citable) accession number: Q84WU8
Secondary accession number(s): O81076, Q0WWR8, Q8VZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.