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Protein

ATP-dependent zinc metalloprotease FTSH 3, mitochondrial

Gene

FTSH3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi586Zinc; catalyticBy similarity1
Active sitei587By similarity1
Metal bindingi590Zinc; catalyticBy similarity1
Metal bindingi662Zinc; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi362 – 369ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent peptidase activity Source: TAIR
  • metalloendopeptidase activity Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

  • response to cytokinin Source: TAIR

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B20 399

Protein family/group databases

MEROPSiM41.022

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FTSH 3, mitochondrial (EC:3.4.24.-)
Short name:
AtFTSH3
Gene namesi
Name:FTSH3
Ordered Locus Names:At2g29080
ORF Names:T9I4.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29080
TAIRilocus:2066128 AT2G29080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 83MitochondrionSequence analysisAdd BLAST83
ChainiPRO_000034132984 – 809ATP-dependent zinc metalloprotease FTSH 3, mitochondrialAdd BLAST726

Proteomic databases

PaxDbiQ84WU8
PRIDEiQ84WU8

PTM databases

SwissPalmiQ84WU8

Expressioni

Inductioni

By heat and high light.1 Publication

Gene expression databases

ExpressionAtlasiQ84WU8 baseline and differential
GenevisibleiQ84WU8 AT

Interactioni

Protein-protein interaction databases

BioGridi2806, 3 interactors
STRINGi3702.AT2G29080.1

Structurei

3D structure databases

ProteinModelPortaliQ84WU8
SMRiQ84WU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi270 – 273Poly-Leu4
Compositional biasi274 – 304Gly-richAdd BLAST31

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0731 Eukaryota
COG0465 LUCA
HOGENOMiHOG000217277
InParanoidiQ84WU8
KOiK08956
OMAiGNGIPAK
OrthoDBiEOG093603BD
PhylomeDBiQ84WU8

Family and domain databases

HAMAPiMF_01458 FtsH, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR005936 FtsH
IPR027417 P-loop_NTPase
IPR011546 Pept_M41_FtsH_extracell
IPR000642 Peptidase_M41
IPR037219 Peptidase_M41-like
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF06480 FtsH_ext, 1 hit
PF01434 Peptidase_M41, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF140990 SSF140990, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01241 FtsH_fam, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q84WU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMIFFSKLN RSISRSKGFL YGGGVRSAAR LLTSPGLEAA SVNEVEGGLG
60 70 80 90 100
FIRRHFASLA SRKGLVNNDL IGVFANPRLR RFFSDEAPKK KNYENYFPKD
110 120 130 140 150
KQEPKSDQKS EHKEGSEKNE NENVGDMFMN RFQNLLIPLL ALAVFFSTFS
160 170 180 190 200
FGSGEQQQIS FQEFKNKLLE PGLVDHIDVS NKSVAKVYVR STPKDQQTTD
210 220 230 240 250
VVHGNGNGIP AKRTGGQYKY YFNIGSVDSF EEKLEEAQEA LGVDRHEYVP
260 270 280 290 300
VTYVSEMVWY QEFMRFAPTL LLLGTLIYGA RRMQGGLGVG GTGGKNGRGI
310 320 330 340 350
FNIGKATITR ADKHSKNKIY FKDVAGCDEA KQEIMEFVHF LKNPKKYEDL
360 370 380 390 400
GAKIPKGALL VGPPGTGKTL LAKATAGESG VPFLSISGSD FMEMFVGVGP
410 420 430 440 450
SRVRHLFQEA RQAAPSIIFI DEIDAIGRAR GRGGLGGNDE RESTLNQLLV
460 470 480 490 500
EMDGFGTTAG VVVLAGTNRP DILDKALLRP GRFDRQITID KPDIKGRDQI
510 520 530 540 550
FKIYLKKIKL DHEPSYYSQR LAALTPGFAG ADIANVCNEA ALIAARHEGA
560 570 580 590 600
TVTMAHFESA IDRVIGGLEK KNRVISKLER RTVAYHESGH AVVGWFLEHA
610 620 630 640 650
EPLLKVTIVP RGTAALGFAQ YVPNENLLMT KEQLFDMTCM TLGGRAAEQV
660 670 680 690 700
LIGKISTGAQ NDLEKVTKMT YAQVAVYGFS DKVGLLSFPP RDDGYDFSKP
710 720 730 740 750
YSNKTGAIID EEVRDWVAKA YERTVELVEE HKVKVAEIAE LLLEKEVLHQ
760 770 780 790 800
DDLLKILGER PFKSAEVTNY DRFKSGFEET EKDSAATPTV EPVVDDGAPP

PFEPQVVPT
Length:809
Mass (Da):89,353
Last modified:June 1, 2003 - v1
Checksum:i2A54BBC8F8786429
GO

Sequence cautioni

The sequence AAC33234 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155E → D in AAL36270 (PubMed:14593172).Curated1
Sequence conflicti613T → A in BAE98430 (Ref. 4) Curated1
Sequence conflicti647A → P in AAL36270 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005315 Genomic DNA Translation: AAC33234.1 Different initiation.
CP002685 Genomic DNA Translation: AEC08208.1
BT002743 mRNA Translation: AAO22572.1
AY063914 mRNA Translation: AAL36270.1
AK226271 mRNA Translation: BAE98430.1
PIRiT02738
RefSeqiNP_850129.1, NM_179798.2
UniGeneiAt.24335

Genome annotation databases

EnsemblPlantsiAT2G29080.1; AT2G29080.1; AT2G29080
GeneIDi817456
GrameneiAT2G29080.1; AT2G29080.1; AT2G29080
KEGGiath:AT2G29080

Similar proteinsi

Entry informationi

Entry nameiFTSH3_ARATH
AccessioniPrimary (citable) accession number: Q84WU8
Secondary accession number(s): O81076, Q0WWR8, Q8VZR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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