Q84WU6 (ARFQ_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Auxin response factor 17

Gene names

Name:	ARF17
Ordered Locus Names:	At1g77850
ORF Names:	F28K19.6, T32E8.16

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Auxin response factors (ARFs) are transcriptional factors that binds specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Ref.5
Subunit structure	Homo and heterodimers By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the ARF family. Contains 1 TF-B3 DNA-binding domain.
Sequence caution	The sequence AAF17677.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAG51629.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Auxin signaling pathway Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adventitious root development Inferred from mutant phenotype. Source: TAIR anatomical structure morphogenesis Inferred from mutant phenotype. Source: TAIR auxin mediated signaling pathway Traceable author statement. Source: TAIR regulation of transcription, DNA-dependent Traceable author statement. Source: TAIR transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 585	585	Auxin response factor 17		PRO_0000111521
Regions
	DNA binding	119 – 221	103	TF-B3
Natural variations
	Natural variant	414	1	Y → F in strain: cv. Ag-0, cv. An-1, cv. Cvi-0, cv. Edi-0, cv. Kas-2, cv. Ll-0, cv. Nok-3, cv. Wassilewskija, cv. Wei-0 and cv. Wt-5. Ref.4
	Natural variant	518	1	S → P in strain: cv. Ag-0, cv. An-1, cv. Cvi-0, cv. Edi-0, cv. Ei-2, cv. Gy-2, cv. Kas-2, cv. Ll-0, cv. Mt-0, cv. Nok-3, cv. Wassilewskija, cv. Wei-0 and cv. Wt-5. Ref.4
Experimental info
	Sequence conflict	102	1	R → Q in AAL07033. Ref.3
	Sequence conflict	456	1	G → R in AAL07033. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q84WU6 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C36984B4326B8620	FASTA	585	63,742
	10 20 30 40 50 60 MSPPSATAGD INHREVDPTI WRACAGASVQ IPVLHSRVYY FPQGHVEHCC PLLSTLPSST 70 80 90 100 110 120 SPVPCIITSI QLLADPVTDE VFAHLILQPM TQQQFTPTNY SRFGRFDGDV DDNNKVTTFA 130 140 150 160 170 180 KILTPSDANN GGGFSVPRFC ADSVFPLLNF QIDPPVQKLY VTDIHGAVWD FRHIYRGTPR 190 200 210 220 230 240 RHLLTTGWSK FVNSKKLIAG DSVVFMRKSA DEMFIGVRRT PISSSDGGSS YYGGDEYNGY 250 260 270 280 290 300 YSQSSVAKED DGSPKKTFRR SGNGKLTAEA VTDAINRASQ GLPFEVVFYP AAGWSEFVVR 310 320 330 340 350 360 AEDVESSMSM YWTPGTRVKM AMETEDSSRI TWFQGIVSST YQETGPWRGS PWKQLQITWD 370 380 390 400 410 420 EPEILQNVKR VNPWQVEIAA HATQLHTPFP PAKRLKYPQP GGGFLSGDDG EILYPQSGLS 430 440 450 460 470 480 SAAAPDPSPS MFSYSTFPAG MQGARQYDFG SFNPTGFIGG NPPQLFTNNF LSPLPDLGKV 490 500 510 520 530 540 STEMMNFGSP PSDNLSPNSN TTNLSSGNDL VGNRGPLSKK VNSIQLFGKI ITVEEHSESG 550 560 570 580 PAESGLCEED GSKESSDNET QLSLSHAPPS VPKHSNSNAG SSSQG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Sequence variation of microRNAs and their binding sites in Arabidopsis." Ehrenreich I.M., Purugganan M.D. Plant Physiol. 146:1974-1982(2008) [PubMed: 18305205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 375-533, VARIANTS PHE-414 AND PRO-518. Strain: cv. Ag-0, cv. An-1, cv. Bay-0, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-1, cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0, cv. Mrk-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo, cv. Wa-1, cv. Wassilewskija, cv. Wei-0 and cv. Wt-5.
[5]	"Auxin-responsive gene expression: genes, promoters and regulatory factors." Hagen G., Guilfoyle T.J. Plant Mol. Biol. 49:373-385(2002) [PubMed: 12036261] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE, FUNCTION.
[6]	"The plant B3 superfamily." Swaminathan K., Peterson K., Jack T. Trends Plant Sci. 13:647-655(2008) [PubMed: 18986826] [Abstract] Cited for: GENE FAMILY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009243 Genomic DNA. Translation: AAF17677.1. Sequence problems. AC012193 Genomic DNA. Translation: AAG51629.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE36034.1. AY056184 mRNA. Translation: AAL07033.1. BT002749 mRNA. Translation: AAO22578.1. EU550144 Genomic DNA. Translation: ACB30930.1. EU550145 Genomic DNA. Translation: ACB30931.1. EU550146 Genomic DNA. Translation: ACB30932.1. EU550147 Genomic DNA. Translation: ACB30933.1. EU550148 Genomic DNA. Translation: ACB30934.1. EU550149 Genomic DNA. Translation: ACB30935.1. EU550150 Genomic DNA. Translation: ACB30936.1. EU550151 Genomic DNA. Translation: ACB30937.1. EU550152 Genomic DNA. Translation: ACB30938.1. EU550153 Genomic DNA. Translation: ACB30939.1. EU550154 Genomic DNA. Translation: ACB30940.1. EU550155 Genomic DNA. Translation: ACB30941.1. EU550156 Genomic DNA. Translation: ACB30942.1. EU550157 Genomic DNA. Translation: ACB30943.1. EU550158 Genomic DNA. Translation: ACB30944.1. EU550159 Genomic DNA. Translation: ACB30945.1. EU550160 Genomic DNA. Translation: ACB30946.1. EU550161 Genomic DNA. Translation: ACB30947.1. EU550162 Genomic DNA. Translation: ACB30948.1. EU550163 Genomic DNA. Translation: ACB30949.1. EU550164 Genomic DNA. Translation: ACB30950.1. EU550165 Genomic DNA. Translation: ACB30951.1. EU550166 Genomic DNA. Translation: ACB30952.1. EU550167 Genomic DNA. Translation: ACB30953.1.
IPI	IPI00522722.
PIR	D96808.
RefSeq	NP_565161.1. NM_106434.1.
UniGene	At.26363.
3D structure databases
ProteinModelPortal	Q84WU6.
SMR	Q84WU6. Positions 115-223.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q84WU6. 3 interactions.
STRING	Q84WU6.
Proteomic databases
PRIDE	Q84WU6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G77850.1; AT1G77850.1; AT1G77850.
GeneID	844120.
GenomeReviews	Gene locus AT1G77850 in contig CT485782_GR.
KEGG	ath:AT1G77850.
NMPDR	fig|3702.1.peg.7330.
Organism-specific databases
GeneFarm	3413. 345.
TAIR	At1g77850.
Phylogenomic databases
GeneTree	EPGT00070000028280.
OMA	VSTELNI.
PhylomeDB	Q84WU6.
ProtClustDB	CLSN2689276.
Gene expression databases
ArrayExpress	Q84WU6.
Genevestigator	Q84WU6.
GermOnline	AT1G77850. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR010525. Auxin_resp. IPR003340. B3_DNA-bd. IPR015300. DNA-bd_pseudobarrel. [Graphical view]
Gene3D	G3DSA:2.40.330.10. G3DSA:2.40.330.10. 1 hit.
Pfam	PF06507. Auxin_resp. 1 hit. PF02362. B3. 1 hit. [Graphical view]
SMART	SM01019. B3. 1 hit. [Graphical view]
SUPFAM	SSF101936. Restrict_endonuc_II_EcoRII_N. 1 hit.
PROSITE	PS50863. B3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARFQ_ARATH

Accession

Primary (citable) accession number: Q84WU6
Secondary accession number(s): B2CTG7 , B2CTG8, B2CTH0, Q93ZY5, Q9CA12, Q9SH16

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program