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Q84WC6

- UBP7_ARATH

UniProt

Q84WC6 - UBP7_ARATH

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Protein
Ubiquitin carboxyl-terminal hydrolase 7
Gene
UBP7, At3g21280, MXL8.15
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131Nucleophile By similarity
Active sitei425 – 4251Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

BioCyciARA:AT3G21280-MONOMER.

Protein family/group databases

MEROPSiC19.A05.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Short name:
AtUBP7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:UBP7
Ordered Locus Names:At3g21280
ORF Names:MXL8.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G21280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Ubiquitin carboxyl-terminal hydrolase 7
PRO_0000313034Add
BLAST

Proteomic databases

PaxDbiQ84WC6.
PRIDEiQ84WC6.

Expressioni

Gene expression databases

GenevestigatoriQ84WC6.

Interactioni

Subunit structurei

Interacts with calmodulin (CaM).1 Publication

Protein-protein interaction databases

STRINGi3702.AT3G21280.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ84WC6.
SMRiQ84WC6. Positions 4-473.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7776Ubiquitin-like
Add
BLAST
Domaini104 – 473370USP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 19020Calmodulin-binding By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiNOG286607.
HOGENOMiHOG000202292.
InParanoidiQ84WC6.
KOiK11843.
PhylomeDBiQ84WC6.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q84WC6-1 [UniParc]FASTAAdd to Basket

« Hide

MLTVSVKWQK KVFESIEIDT SQPPFVFKAQ LYDLSGVPPE RQKIMVKGGL    50
LKDDADWSTL GLKNGQKLMM MGTADEIVKA PEKGPVFMED LPEEQQAANL 100
GYSAGLVNLG NTCYMNSTMQ CLISVPELKS ELSNYQSART KDVDQTSHML 150
TVATRELFSE LDKSVKAVAP MPFWMVLQKK YPQFAQLHNG NHMQQDAEEC 200
WTQMLYTLSQ SLKLPSPSED PDAVKALFGL NLLNRLHCQE SSEESSETES 250
VFSLKCHISH EVNHLHEGLK HGLKGELEKT SPSLGRTAVY VKESLIDSLP 300
RYLTVQFVRF FWKRESNQKA KILRKVDYPL ELDIYDLCSE DLRKKLEAPR 350
QKLRDIEGQK LGLQASAKSS SKGDDVKMTD AEGSSNQSGE SSTGDQQEGA 400
SPHMTGIYDL VSVLTHKGRS ADSGHYVAWV KQESGKWVQY DDANTSLQRG 450
EDIIKLSGGG DWHMAYIVMY KARLISM 477
Length:477
Mass (Da):53,516
Last modified:June 1, 2003 - v1
Checksum:i82B469EE366B5E13
GO

Sequence cautioni

The sequence AEE76487.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAB01721.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091S → F in AAG42752. 1 Publication
Sequence conflicti217 – 2171P → A in AAG42752. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302661 mRNA. Translation: AAG42752.1.
AB023045 Genomic DNA. Translation: BAB01721.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE76487.1. Different initiation.
BT003992 mRNA. Translation: AAO42031.1.
RefSeqiNP_566680.2. NM_113023.3.
UniGeneiAt.8082.

Genome annotation databases

EnsemblPlantsiAT3G21280.1; AT3G21280.1; AT3G21280.
GeneIDi821682.
KEGGiath:AT3G21280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF302661 mRNA. Translation: AAG42752.1 .
AB023045 Genomic DNA. Translation: BAB01721.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE76487.1 . Different initiation.
BT003992 mRNA. Translation: AAO42031.1 .
RefSeqi NP_566680.2. NM_113023.3.
UniGenei At.8082.

3D structure databases

ProteinModelPortali Q84WC6.
SMRi Q84WC6. Positions 4-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G21280.1-P.

Protein family/group databases

MEROPSi C19.A05.

Proteomic databases

PaxDbi Q84WC6.
PRIDEi Q84WC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G21280.1 ; AT3G21280.1 ; AT3G21280 .
GeneIDi 821682.
KEGGi ath:AT3G21280.

Organism-specific databases

TAIRi AT3G21280.

Phylogenomic databases

eggNOGi NOG286607.
HOGENOMi HOG000202292.
InParanoidi Q84WC6.
KOi K11843.
PhylomeDBi Q84WC6.

Enzyme and pathway databases

BioCyci ARA:AT3G21280-MONOMER.

Gene expression databases

Genevestigatori Q84WC6.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
    Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
    Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY ORGANIZATION, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulin."
    Moon B.C., Choi M.S., Kang Y.H., Kim M.C., Cheong M.S., Park C.Y., Yoo J.H., Koo S.C., Lee S.M., Lim C.O., Cho M.J., Chung W.S.
    FEBS Lett. 579:3885-3890(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CALMODULIN.

Entry informationi

Entry nameiUBP7_ARATH
AccessioniPrimary (citable) accession number: Q84WC6
Secondary accession number(s): F4IXI8, Q9FPT3, Q9LU31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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