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Q84WC6

- UBP7_ARATH

UniProt

Q84WC6 - UBP7_ARATH

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Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

UBP7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131NucleophilePROSITE-ProRule annotation
Active sitei425 – 4251Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

BioCyciARA:AT3G21280-MONOMER.

Protein family/group databases

MEROPSiC19.A05.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Short name:
AtUBP7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:UBP7
Ordered Locus Names:At3g21280
ORF Names:MXL8.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G21280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Ubiquitin carboxyl-terminal hydrolase 7PRO_0000313034Add
BLAST

Proteomic databases

PaxDbiQ84WC6.
PRIDEiQ84WC6.

Expressioni

Gene expression databases

GenevestigatoriQ84WC6.

Interactioni

Subunit structurei

Interacts with calmodulin (CaM).1 Publication

Protein-protein interaction databases

STRINGi3702.AT3G21280.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ84WC6.
SMRiQ84WC6. Positions 4-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7776Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini104 – 473370USPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 19020Calmodulin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiNOG286607.
HOGENOMiHOG000202292.
InParanoidiQ84WC6.
KOiK11843.
PhylomeDBiQ84WC6.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q84WC6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTVSVKWQK KVFESIEIDT SQPPFVFKAQ LYDLSGVPPE RQKIMVKGGL
60 70 80 90 100
LKDDADWSTL GLKNGQKLMM MGTADEIVKA PEKGPVFMED LPEEQQAANL
110 120 130 140 150
GYSAGLVNLG NTCYMNSTMQ CLISVPELKS ELSNYQSART KDVDQTSHML
160 170 180 190 200
TVATRELFSE LDKSVKAVAP MPFWMVLQKK YPQFAQLHNG NHMQQDAEEC
210 220 230 240 250
WTQMLYTLSQ SLKLPSPSED PDAVKALFGL NLLNRLHCQE SSEESSETES
260 270 280 290 300
VFSLKCHISH EVNHLHEGLK HGLKGELEKT SPSLGRTAVY VKESLIDSLP
310 320 330 340 350
RYLTVQFVRF FWKRESNQKA KILRKVDYPL ELDIYDLCSE DLRKKLEAPR
360 370 380 390 400
QKLRDIEGQK LGLQASAKSS SKGDDVKMTD AEGSSNQSGE SSTGDQQEGA
410 420 430 440 450
SPHMTGIYDL VSVLTHKGRS ADSGHYVAWV KQESGKWVQY DDANTSLQRG
460 470
EDIIKLSGGG DWHMAYIVMY KARLISM
Length:477
Mass (Da):53,516
Last modified:June 1, 2003 - v1
Checksum:i82B469EE366B5E13
GO

Sequence cautioni

The sequence AEE76487.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB01721.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091S → F in AAG42752. (PubMed:11115897)Curated
Sequence conflicti217 – 2171P → A in AAG42752. (PubMed:11115897)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302661 mRNA. Translation: AAG42752.1.
AB023045 Genomic DNA. Translation: BAB01721.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE76487.1. Different initiation.
BT003992 mRNA. Translation: AAO42031.1.
RefSeqiNP_566680.2. NM_113023.3.
UniGeneiAt.8082.

Genome annotation databases

EnsemblPlantsiAT3G21280.1; AT3G21280.1; AT3G21280.
GeneIDi821682.
KEGGiath:AT3G21280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302661 mRNA. Translation: AAG42752.1 .
AB023045 Genomic DNA. Translation: BAB01721.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE76487.1 . Different initiation.
BT003992 mRNA. Translation: AAO42031.1 .
RefSeqi NP_566680.2. NM_113023.3.
UniGenei At.8082.

3D structure databases

ProteinModelPortali Q84WC6.
SMRi Q84WC6. Positions 4-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G21280.1-P.

Protein family/group databases

MEROPSi C19.A05.

Proteomic databases

PaxDbi Q84WC6.
PRIDEi Q84WC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G21280.1 ; AT3G21280.1 ; AT3G21280 .
GeneIDi 821682.
KEGGi ath:AT3G21280.

Organism-specific databases

TAIRi AT3G21280.

Phylogenomic databases

eggNOGi NOG286607.
HOGENOMi HOG000202292.
InParanoidi Q84WC6.
KOi K11843.
PhylomeDBi Q84WC6.

Enzyme and pathway databases

BioCyci ARA:AT3G21280-MONOMER.

Gene expression databases

Genevestigatori Q84WC6.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00240. ubiquitin. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
    Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
    Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY ORGANIZATION, NOMENCLATURE.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulin."
    Moon B.C., Choi M.S., Kang Y.H., Kim M.C., Cheong M.S., Park C.Y., Yoo J.H., Koo S.C., Lee S.M., Lim C.O., Cho M.J., Chung W.S.
    FEBS Lett. 579:3885-3890(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CALMODULIN.

Entry informationi

Entry nameiUBP7_ARATH
AccessioniPrimary (citable) accession number: Q84WC6
Secondary accession number(s): F4IXI8, Q9FPT3, Q9LU31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3