Q84V36 (POLC3_CHEAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Polcalcin Che a 3 Alternative name(s): Calcium-binding pollen allergen Che a 3 Allergen=Che a 3
Organism	Chenopodium album (Lamb's-quarters)
Taxonomic identifier	3559 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Amaranthaceae › Chenopodium

Protein attributes

Sequence length	86 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Binds to IgE. Ref.1
Sequence similarities	Contains 2 EF-hand domains.

Ontologies

Keywords
Disease	Allergen
Domain	Repeat
Ligand	Calcium Metal-binding
Technical term	3D-structure
Gene Ontology (GO)
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 86

86

Polcalcin Che a 3

PRO_0000073671

Regions

Domain

8 – 43

36

EF-hand 1

Domain

43 – 78

36

EF-hand 2

Calcium binding

21 – 32

12

1 Potential

Calcium binding

56 – 67

12

2 Potential

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

86

Helix Strand Turn

Details...

Helix

7 – 20

14

Beta strand

25 – 29

5

Helix

30 – 38

9

Turn

39 – 42

4

Helix

45 – 55

11

Beta strand

60 – 63

4

Helix

65 – 74

10

Turn

76 – 78

3

Helix

79 – 85

7

Sequences

	Sequence		Length	Mass (Da)
	Q84V36 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D950CE65546181BB	FASTA	86	9,552
	10 20 30 40 50 60 MAAEDTPQDI ADRERIFKRF DTNGDGKISS SELGDALKTL GSVTPDEVRR MMAEIDTDGD 70 80 GFISFDEFTD FARANRGLVK DVSKIF

References

[1]	"Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: isolation, amino acid sequences, and immunologic properties." Barderas R., Villalba M., Pascual C.Y., Batanero E., Rodriguez R. J. Allergy Clin. Immunol. 113:1192-1198(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN. Tissue: Pollen.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY082338 mRNA. Translation: AAL92871.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OPO	X-ray	1.75	A/B/C/D	1-86	[»]

ProteinModelPortal

Q84V36.

SMR

Q84V36. Positions 2-86.

ModBase

Search...

Protein family/group databases

Allergome

1069. Che a 3.
3190. Che a 3.0101.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.238.10. 1 hit.

InterPro

IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]

Pfam

PF13499. EF_hand_5. 1 hit.
[Graphical view]

SMART

SM00054. EFh. 2 hits.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q84V36.

Entry information

Entry name

POLC3_CHEAL

Accession

Primary (citable) accession number: Q84V36

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program