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Q84UI5

- MPK1_ORYSJ

UniProt

Q84UI5 - MPK1_ORYSJ

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Protein
Mitogen-activated protein kinase 1
Gene
MPK1, MAPK6, SIPK, Os06g0154500, LOC_Os06g06090, OSJNBa0085L11.14
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in sphingolipid elicitor (SE)-dependent defense signaling pathway. Acts downstream of heterotrimeric G protein alpha subunit and small GTPase RAC1. May regulate the expression of various genes involved in biotic and abiotic stress response.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity. Activated in response to sphingolipid elicitor (SE).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961ATP By similarity
Active sitei193 – 1931Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 819ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. camalexin biosynthetic process Source: EnsemblPlants/Gramene
  2. cell division Source: EnsemblPlants/Gramene
  3. induced systemic resistance, jasmonic acid mediated signaling pathway Source: EnsemblPlants/Gramene
  4. inflorescence development Source: EnsemblPlants/Gramene
  5. ovule development Source: EnsemblPlants/Gramene
  6. priming of cellular response to stress Source: EnsemblPlants/Gramene
  7. regulation of stomatal complex development Source: EnsemblPlants/Gramene
  8. regulation of stomatal complex patterning Source: EnsemblPlants/Gramene
  9. response to UV-B Source: EnsemblPlants/Gramene
  10. response to abscisic acid Source: EnsemblPlants/Gramene
  11. response to cold Source: EnsemblPlants/Gramene
  12. response to ethylene Source: EnsemblPlants/Gramene
  13. response to hydrogen peroxide Source: EnsemblPlants/Gramene
  14. response to salt stress Source: EnsemblPlants/Gramene
  15. root development Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Plant defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205014. CREB phosphorylation through the activation of Ras.
REACT_214549. Signalling to ERK5.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 1 (EC:2.7.11.24)
Short name:
MAP kinase 1
Alternative name(s):
MAP kinase 6
OsMAPK6
OsSIPK
Gene namesi
Name:MPK1
Synonyms:MAPK6, SIPK
Ordered Locus Names:Os06g0154500, LOC_Os06g06090
ORF Names:OSJNBa0085L11.14
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 6

Organism-specific databases

GrameneiQ84UI5.

Subcellular locationi

GO - Cellular componenti

  1. phragmoplast Source: EnsemblPlants/Gramene
  2. preprophase band Source: EnsemblPlants/Gramene
  3. trans-Golgi network Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Mitogen-activated protein kinase 1
PRO_0000239744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251Phosphothreonine By similarity
Modified residuei227 – 2271Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-225 and Tyr-227, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ84UI5.

Interactioni

Subunit structurei

May interact with RAC1.

Protein-protein interaction databases

STRINGi39947.LOC_Os06g06090.1.

Structurei

3D structure databases

ProteinModelPortaliQ84UI5.
SMRiQ84UI5. Positions 56-398.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 352286Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi225 – 2273TXY

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 3412Poly-Ala
Add
BLAST

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK14512.
OMAiSDEPVCS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q84UI5-1 [UniParc]FASTAAdd to Basket

« Hide

MDAGAQPPDT EMAEAGGGQQ PPAAAAAAGA GAGAGMMENI QATLSHGGRF    50
IQYNIFGNVF EVTAKYKPPI LPIGKGAYGI VCSALNSETG EQVAIKKIAN 100
AFDNKIDAKR TLREIKLLRH MDHENIVAIR DIIPPPQRNS FNDVYIAYEL 150
MDTDLHQIIR SNQALSEEHC QYFLYQILRG LKYIHSANVL HRDLKPSNLL 200
LNANCDLKIC DFGLARTTSE TDFMTEYVVT RWYRAPELLL NSSEYTAAID 250
VWSVGCIFME LMDRKPLFPG RDHVHQLRLL MELIGTPNEA DLDFVNENAR 300
RYIRQLPRHA RQSFPEKFPH VHPLAIDLVE KMLTFDPRQR ITVEGALAHP 350
YLASLHDISD EPVCSSPFSF DFEQHALSEE QMKDLIYQEG LAFNPDYQ 398
Length:398
Mass (Da):44,858
Last modified:June 1, 2003 - v1
Checksum:i46E2907463A7C490
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB183398 mRNA. Translation: BAD34534.1.
AJ535841 mRNA. Translation: CAD59793.1.
AP006533 Genomic DNA. Translation: BAD69291.1.
RefSeqiNP_001056846.1. NM_001063381.1.
UniGeneiOs.19011.

Genome annotation databases

EnsemblPlantsiOS06T0154500-01; OS06T0154500-01; OS06G0154500.
GeneIDi4340170.
KEGGiosa:4340170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB183398 mRNA. Translation: BAD34534.1 .
AJ535841 mRNA. Translation: CAD59793.1 .
AP006533 Genomic DNA. Translation: BAD69291.1 .
RefSeqi NP_001056846.1. NM_001063381.1.
UniGenei Os.19011.

3D structure databases

ProteinModelPortali Q84UI5.
SMRi Q84UI5. Positions 56-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os06g06090.1.

Proteomic databases

PRIDEi Q84UI5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS06T0154500-01 ; OS06T0154500-01 ; OS06G0154500 .
GeneIDi 4340170.
KEGGi osa:4340170.

Organism-specific databases

Gramenei Q84UI5.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K14512.
OMAi SDEPVCS.

Enzyme and pathway databases

Reactomei REACT_205014. CREB phosphorylation through the activation of Ras.
REACT_214549. Signalling to ERK5.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A sphingolipid elicitor-inducible mitogen-activated protein kinase is regulated by the small GTPase OsRac1 and heterotrimeric G-protein in rice."
    Lieberherr D., Thao N.P., Nakashima A., Umemura K., Kawasaki T., Shimamoto K.
    Plant Physiol. 138:1644-1652(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, INTERACTION WITH RAC1.
    Strain: cv. Kinmaze.
  2. "Identification of a novel rice (Oryza sativa L. japonica-type cv. Nipponbare) mitogen-activated protein kinase OsSIPK, an orthologue of tobacco NtSIPK."
    Rakwal R., Jwa N.S., Shibato J., Iwahashi H.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Nipponbare.
    Tissue: Leaf.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMPK1_ORYSJ
AccessioniPrimary (citable) accession number: Q84UI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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