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Protein

Mitogen-activated protein kinase 1

Gene

MPK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in sphingolipid elicitor (SE)-dependent defense signaling pathway. Acts downstream of heterotrimeric G protein alpha subunit and small GTPase RAC1. May regulate the expression of various genes involved in biotic and abiotic stress response.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation (By similarity). Activated in response to sphingolipid elicitor (SE).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ATPPROSITE-ProRule annotation1
Active sitei193Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 81ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processPlant defense
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-198753 ERK/MAPK targets
R-OSA-198765 Signalling to ERK5
R-OSA-202670 ERKs are inactivated
R-OSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-OSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 1 (EC:2.7.11.24)
Short name:
MAP kinase 1
Alternative name(s):
MAP kinase 6
OsMAPK6
OsSIPK
Gene namesi
Name:MPK1
Synonyms:MAPK6, SIPK
Ordered Locus Names:Os06g0154500, LOC_Os06g06090
ORF Names:OSJNBa0085L11.14
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397441 – 398Mitogen-activated protein kinase 1Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphothreonineBy similarity1
Modified residuei227PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-225 and Tyr-227, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ84UI5
PRIDEiQ84UI5

Expressioni

Gene expression databases

ExpressionAtlasiQ84UI5 differential
GenevisibleiQ84UI5 OS

Interactioni

Subunit structurei

May interact with RAC1.

Protein-protein interaction databases

STRINGi39947.LOC_Os06g06090.1

Structurei

3D structure databases

ProteinModelPortaliQ84UI5
SMRiQ84UI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 352Protein kinasePROSITE-ProRule annotationAdd BLAST286

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi225 – 227TXY3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 34Poly-AlaAdd BLAST12

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
HOGENOMiHOG000233024
InParanoidiQ84UI5
KOiK14512
OMAiMEKCLTF
OrthoDBiEOG09360BWL

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q84UI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAGAQPPDT EMAEAGGGQQ PPAAAAAAGA GAGAGMMENI QATLSHGGRF
60 70 80 90 100
IQYNIFGNVF EVTAKYKPPI LPIGKGAYGI VCSALNSETG EQVAIKKIAN
110 120 130 140 150
AFDNKIDAKR TLREIKLLRH MDHENIVAIR DIIPPPQRNS FNDVYIAYEL
160 170 180 190 200
MDTDLHQIIR SNQALSEEHC QYFLYQILRG LKYIHSANVL HRDLKPSNLL
210 220 230 240 250
LNANCDLKIC DFGLARTTSE TDFMTEYVVT RWYRAPELLL NSSEYTAAID
260 270 280 290 300
VWSVGCIFME LMDRKPLFPG RDHVHQLRLL MELIGTPNEA DLDFVNENAR
310 320 330 340 350
RYIRQLPRHA RQSFPEKFPH VHPLAIDLVE KMLTFDPRQR ITVEGALAHP
360 370 380 390
YLASLHDISD EPVCSSPFSF DFEQHALSEE QMKDLIYQEG LAFNPDYQ
Length:398
Mass (Da):44,858
Last modified:June 1, 2003 - v1
Checksum:i46E2907463A7C490
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB183398 mRNA Translation: BAD34534.1
AJ535841 mRNA Translation: CAD59793.1
AP006533 Genomic DNA Translation: BAD69291.1
AP008212 Genomic DNA Translation: BAF18760.1
AP014962 Genomic DNA Translation: BAS96224.1
RefSeqiXP_015643193.1, XM_015787707.1
UniGeneiOs.19011

Genome annotation databases

EnsemblPlantsiOs06t0154500-01; Os06t0154500-01; Os06g0154500
GeneIDi4340170
GrameneiOs06t0154500-01; Os06t0154500-01; Os06g0154500
KEGGiosa:4340170

Similar proteinsi

Entry informationi

Entry nameiMPK1_ORYSJ
AccessioniPrimary (citable) accession number: Q84UI5
Secondary accession number(s): Q0DEG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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