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Protein

Mitochondrial arginine transporter BAC1

Gene

BAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial arginine transporter that catalyzes the counter-exchange of arginine with lysine, ornithine, arginine and histidine. Substrate preference in reconstituted proteoliposomes is arginine > lysine > ornithine > histidine. May be involved in the delivery of arginine, released from seed reserves, to mitochondrial arginase and the export of ornithine.2 Publications

Enzyme regulationi

Inhibited by mercuric chloride.1 Publication

Kineticsi

  1. KM=0.19 mM for arginine (for the recombinant protein in reconstituted proteoliposomes)2 Publications
  2. KM=0.68 mM for lysine (for the recombinant protein in reconstituted proteoliposomes)2 Publications
  3. KM=2.17 mM for ornithine (for the recombinant protein in reconstituted proteoliposomes)2 Publications
  1. Vmax=48 µmol/min/g enzyme toward arginine (for the recombinant protein in reconstituted proteoliposomes)2 Publications

pH dependencei

Optimum pH is 7.0-9.0.2 Publications

GO - Molecular functioni

  • arginine transmembrane transporter activity Source: TAIR
  • L-histidine transmembrane transporter activity Source: TAIR
  • L-lysine transmembrane transporter activity Source: TAIR

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-ATH-70635 Urea cycle
SABIO-RKiQ84UC7

Protein family/group databases

TCDBi2.A.29.8.6 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial arginine transporter BAC1
Alternative name(s):
Mitochondrial basic amino acid carrier 1
Short name:
AtMBAC1
Gene namesi
Name:BAC1
Synonyms:MBAC1
Ordered Locus Names:At2g33820
ORF Names:T1B8.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT2G33820
TAIRilocus:2057671 AT2G33820

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei178 – 197Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 242Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei288 – 308Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004207581 – 311Mitochondrial arginine transporter BAC1Add BLAST311

Proteomic databases

PaxDbiQ84UC7
PRIDEiQ84UC7

Expressioni

Tissue specificityi

High expression in flowers and siliques. Lower expression in leaves and stems.1 Publication

Gene expression databases

ExpressionAtlasiQ84UC7 baseline and differential
GenevisibleiQ84UC7 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G33820.1

Structurei

3D structure databases

ProteinModelPortaliQ84UC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 101Solcar 1Add BLAST90
Repeati111 – 203Solcar 2Add BLAST93
Repeati219 – 305Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758 Eukaryota
ENOG410XS86 LUCA
HOGENOMiHOG000168307
InParanoidiQ84UC7
KOiK15109
OMAiYNFLFFP
OrthoDBiEOG09360HIS
PhylomeDBiQ84UC7

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q84UC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESKTTTGE GFGFYKEYVA GMMAGLATVA VGHPFDTVKV KLQKHNTDVQ
60 70 80 90 100
GLRYKNGLHC ASRILQTEGV KGLYRGATSS FMGMAFESSL MFGIYSQAKL
110 120 130 140 150
FLRGTLPDDG PRPEIIVPSA MFGGAIISFV LCPTELVKCR MQIQGTDSLV
160 170 180 190 200
PNFRRYNSPL DCAVQTVKND GVTGIFRGGS ATLLRECTGN AVFFTVYEYL
210 220 230 240 250
RYHIHSRLED SKLKDGYLVD MGIGVLTGGL GGIACWSAVL PFDVAKTIIQ
260 270 280 290 300
TSSEKATERN PFKVLSSIHK RAGLKGCYAG LGPTIVRAFP ANAAAIVAWE
310
FSMKMLGIKR D
Length:311
Mass (Da):33,727
Last modified:June 1, 2003 - v1
Checksum:iCADB3528083D8CBD
GO

Sequence cautioni

The sequence AAC69138 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186582 mRNA Translation: AAO32062.1
U78721 Genomic DNA Translation: AAC69138.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08890.1
BT025874 mRNA Translation: ABF85776.1
PIRiA84750
RefSeqiNP_180938.2, NM_128941.3
UniGeneiAt.37878

Genome annotation databases

EnsemblPlantsiAT2G33820.1; AT2G33820.1; AT2G33820
GeneIDi817949
GrameneiAT2G33820.1; AT2G33820.1; AT2G33820
KEGGiath:AT2G33820

Entry informationi

Entry nameiBAC1_ARATH
AccessioniPrimary (citable) accession number: Q84UC7
Secondary accession number(s): P93016
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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