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Protein

Glutathione S-transferase F4

Gene

GSTF4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase F4 (EC:2.5.1.18)
Short name:
AtGSTF4
Alternative name(s):
GST class-phi member 4
Glutathione S-transferase 31
Gene namesi
Name:GSTF4
Synonyms:GST31
Ordered Locus Names:At1g02950
ORF Names:F22D16.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G02950
TAIRilocus:2024765 AT1G02950

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135421 – 245Glutathione S-transferase F4Add BLAST245

Proteomic databases

PaxDbiQ84TK0

PTM databases

iPTMnetiQ84TK0

Expressioni

Gene expression databases

ExpressionAtlasiQ84TK0 baseline and differential
GenevisibleiQ84TK0 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G02950.2

Structurei

3D structure databases

ProteinModelPortaliQ84TK0
SMRiQ84TK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 106GST N-terminalAdd BLAST82
Domaini114 – 244GST C-terminalAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 36Glutathione bindingBy similarity2
Regioni64 – 65Glutathione bindingBy similarity2
Regioni77 – 78Glutathione bindingBy similarity2
Regioni90 – 91Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
HOGENOMiHOG000125746
InParanoidiQ84TK0
KOiK00799
OMAiYESRAIT
OrthoDBiEOG09360M18
PhylomeDBiQ84TK0

Family and domain databases

CDDicd03187 GST_C_Phi, 1 hit
InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR034347 GST_Phi_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q84TK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCLQMVFKL FPNWKREAEV KKLVAGYKVH GDPFSTNTRR VLAVLHEKRL
60 70 80 90 100
SYEPITVKLQ TGEHKTEPFL SLNPFGQVPV FEDGSVKLYE SRAITQYIAY
110 120 130 140 150
VHSSRGTQLL NLRSHETMAT LTMWMEIEAH QFDPPASKLT WEQVIKPIYG
160 170 180 190 200
LETDQTIVKE NEAILEKVLN IYEKRLEESR FLACNSFTLV DLHHLPNIQY
210 220 230 240
LLGTPTKKLF EKRSKVRKWV DEITSREAWK MACDQEKSWF NKPRN
Length:245
Mass (Da):28,701
Last modified:June 1, 2003 - v1
Checksum:iA9075D1B448C4886
GO
Isoform 2 (identifier: Q84TK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-25: Missing.

Show »
Length:243
Mass (Da):28,531
Checksum:iB1A834CB5E15B48D
GO

Sequence cautioni

The sequence AAF02871 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04193724 – 25Missing in isoform 2. 3 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009525 Genomic DNA Translation: AAF02871.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27500.1
CP002684 Genomic DNA Translation: AEE27501.1
CP002684 Genomic DNA Translation: AEE27502.1
AF320055 mRNA Translation: AAG40875.1
BT005712 mRNA Translation: AAO64132.1
BT020399 mRNA Translation: AAV97790.1
AK228359 mRNA Translation: BAF00298.1
PIRiA86160
RefSeqiNP_001030937.1, NM_001035860.1 [Q84TK0-2]
NP_563670.1, NM_100176.4 [Q84TK0-2]
NP_849581.1, NM_179250.1 [Q84TK0-1]
UniGeneiAt.24805

Genome annotation databases

EnsemblPlantsiAT1G02950.1; AT1G02950.1; AT1G02950 [Q84TK0-2]
AT1G02950.2; AT1G02950.2; AT1G02950 [Q84TK0-1]
AT1G02950.3; AT1G02950.3; AT1G02950 [Q84TK0-2]
GeneIDi838240
GrameneiAT1G02950.1; AT1G02950.1; AT1G02950 [Q84TK0-2]
AT1G02950.2; AT1G02950.2; AT1G02950 [Q84TK0-1]
AT1G02950.3; AT1G02950.3; AT1G02950 [Q84TK0-2]
KEGGiath:AT1G02950

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGSTF4_ARATH
AccessioniPrimary (citable) accession number: Q84TK0
Secondary accession number(s): Q9FPM2, Q9SRY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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