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Q84TK0

- GSTF4_ARATH

UniProt

Q84TK0 - GSTF4_ARATH

Protein

Glutathione S-transferase F4

Gene

GSTF4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW
    2. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification

    Enzyme and pathway databases

    BioCyciARA:AT1G02950-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase F4 (EC:2.5.1.18)
    Short name:
    AtGSTF4
    Alternative name(s):
    GST class-phi member 4
    Glutathione S-transferase 31
    Gene namesi
    Name:GSTF4
    Synonyms:GST31
    Ordered Locus Names:At1g02950
    ORF Names:F22D16.5
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G02950.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Glutathione S-transferase F4PRO_0000413542Add
    BLAST

    Proteomic databases

    PRIDEiQ84TK0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ84TK0.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G02950.2-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ84TK0.
    SMRiQ84TK0. Positions 26-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 10682GST N-terminalAdd
    BLAST
    Domaini114 – 244131GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 362Glutathione bindingBy similarity
    Regioni64 – 652Glutathione bindingBy similarity
    Regioni77 – 782Glutathione bindingBy similarity
    Regioni90 – 912Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Phi family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000125746.
    InParanoidiQ84TK0.
    KOiK00799.
    OMAiYESRAIT.
    PhylomeDBiQ84TK0.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q84TK0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDCLQMVFKL FPNWKREAEV KKLVAGYKVH GDPFSTNTRR VLAVLHEKRL    50
    SYEPITVKLQ TGEHKTEPFL SLNPFGQVPV FEDGSVKLYE SRAITQYIAY 100
    VHSSRGTQLL NLRSHETMAT LTMWMEIEAH QFDPPASKLT WEQVIKPIYG 150
    LETDQTIVKE NEAILEKVLN IYEKRLEESR FLACNSFTLV DLHHLPNIQY 200
    LLGTPTKKLF EKRSKVRKWV DEITSREAWK MACDQEKSWF NKPRN 245
    Length:245
    Mass (Da):28,701
    Last modified:June 1, 2003 - v1
    Checksum:iA9075D1B448C4886
    GO
    Isoform 2 (identifier: Q84TK0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-25: Missing.

    Show »
    Length:243
    Mass (Da):28,531
    Checksum:iB1A834CB5E15B48D
    GO

    Sequence cautioni

    The sequence AAF02871.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei24 – 252Missing in isoform 2. 3 PublicationsVSP_041937

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009525 Genomic DNA. Translation: AAF02871.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27500.1.
    CP002684 Genomic DNA. Translation: AEE27501.1.
    CP002684 Genomic DNA. Translation: AEE27502.1.
    AF320055 mRNA. Translation: AAG40875.1.
    BT005712 mRNA. Translation: AAO64132.1.
    BT020399 mRNA. Translation: AAV97790.1.
    AK228359 mRNA. Translation: BAF00298.1.
    PIRiA86160.
    RefSeqiNP_001030937.1. NM_001035860.1. [Q84TK0-2]
    NP_563670.1. NM_100176.3. [Q84TK0-2]
    NP_849581.1. NM_179250.1. [Q84TK0-1]
    UniGeneiAt.24805.

    Genome annotation databases

    EnsemblPlantsiAT1G02950.2; AT1G02950.2; AT1G02950. [Q84TK0-1]
    GeneIDi838240.
    KEGGiath:AT1G02950.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009525 Genomic DNA. Translation: AAF02871.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27500.1 .
    CP002684 Genomic DNA. Translation: AEE27501.1 .
    CP002684 Genomic DNA. Translation: AEE27502.1 .
    AF320055 mRNA. Translation: AAG40875.1 .
    BT005712 mRNA. Translation: AAO64132.1 .
    BT020399 mRNA. Translation: AAV97790.1 .
    AK228359 mRNA. Translation: BAF00298.1 .
    PIRi A86160.
    RefSeqi NP_001030937.1. NM_001035860.1. [Q84TK0-2 ]
    NP_563670.1. NM_100176.3. [Q84TK0-2 ]
    NP_849581.1. NM_179250.1. [Q84TK0-1 ]
    UniGenei At.24805.

    3D structure databases

    ProteinModelPortali Q84TK0.
    SMRi Q84TK0. Positions 26-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G02950.2-P.

    Proteomic databases

    PRIDEi Q84TK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G02950.2 ; AT1G02950.2 ; AT1G02950 . [Q84TK0-1 ]
    GeneIDi 838240.
    KEGGi ath:AT1G02950.

    Organism-specific databases

    TAIRi AT1G02950.

    Phylogenomic databases

    HOGENOMi HOG000125746.
    InParanoidi Q84TK0.
    KOi K00799.
    OMAi YESRAIT.
    PhylomeDBi Q84TK0.

    Enzyme and pathway databases

    BioCyci ARA:AT1G02950-MONOMER.

    Gene expression databases

    Genevestigatori Q84TK0.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GENE FAMILY, NOMENCLATURE.
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: cv. Columbia.
    5. "Arabidopsis ORF clones."
      Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    6. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiGSTF4_ARATH
    AccessioniPrimary (citable) accession number: Q84TK0
    Secondary accession number(s): Q9FPM2, Q9SRY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3