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Q84NP7

- AMPD_ORYSJ

UniProt

Q84NP7 - AMPD_ORYSJ

Protein

Probable AMP deaminase

Gene

AMPD

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    AMP deaminase plays a critical role in energy metabolism.By similarity

    Catalytic activityi

    AMP + H2O = IMP + NH3.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi367 – 3671Zinc; catalyticBy similarity
    Metal bindingi369 – 3691Zinc; catalyticBy similarity
    Binding sitei369 – 3691SubstrateBy similarity
    Metal bindingi635 – 6351Zinc; catalyticBy similarity
    Binding sitei638 – 6381SubstrateBy similarity
    Active sitei657 – 6571Proton acceptorPROSITE-ProRule annotation
    Metal bindingi712 – 7121Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. AMP deaminase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00591; UER00663.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable AMP deaminase (EC:3.5.4.6)
    Gene namesi
    Name:AMPD
    Ordered Locus Names:Os07g0693500, LOC_Os07g49270
    ORF Names:P0034A04.129
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 7

    Organism-specific databases

    GrameneiQ84NP7.

    Subcellular locationi

    Membrane; Single-pass membrane protein
    Note: Might be associated with the inner mitochondrial membrane.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 815815Probable AMP deaminasePRO_0000238456Add
    BLAST

    Proteomic databases

    PRIDEiQ84NP7.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ84NP7.
    SMRiQ84NP7. Positions 187-813.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni438 – 4436Substrate bindingBy similarity
    Regioni713 – 7164Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 6915Asp-richAdd
    BLAST
    Compositional biasi125 – 1306Poly-Asp
    Compositional biasi604 – 61613Tyr-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1816.
    HOGENOMiHOG000092200.
    KOiK01490.
    OMAiWTSEENP.

    Family and domain databases

    InterProiIPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR006329. AMPD.
    [Graphical view]
    PANTHERiPTHR11359. PTHR11359. 1 hit.
    PfamiPF00962. A_deaminase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
    PROSITEiPS00485. A_DEAMINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q84NP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSTYALHLA VATLLGASFA AASAYYMHRK TLDQLLRFAR SLDRDHRRRN    50
    RHLLDADDDD DDDPPRDHDR RTTLPIPPGL PPLHTGREGK PIISPASTKR 100
    VGPLVRPTTP RSPVPTVSAF ETIEDSDDDD ENIAPDAKNN AVSLLTNGTI 150
    GSDPLPGKAS QNGDTKPVPS TNMIRSQSAT GSLHGAQHNP VAADILRKEP 200
    EHETFSRINI TAVETPSPDE IEAYKVLQKC LELREKYMFR EEVAPWEKEI 250
    ITDPSTPKPN PNPFYYEQQT KTEHHFEMVD GVIHVYPNKD AKERIYPVAD 300
    ATTFFTDMHY ILRVLAAGDI RTVCYKRLNL LEQKFNLHLM VNADRELLAQ 350
    KAAPHRDFYN VRKVDTHVHH SACMNQKHLL RFIKSKLRKE PDEVVIFRDG 400
    TYLTLKEVFE SLDLTGYDLN VDLLDVHADK STFHRFDKFN LKYNPCGQSR 450
    LREIFLKQDN LIQGRFLAEL TKEVFSDLEA SKYQMAEYRI SIYGRKKSEW 500
    DQMASWIVNN ELYSENVVWL IQIPRIYNVY REMGTINSFQ NLLDNIFLPL 550
    FEVTVDPASH PQLHVFLQQV VGLDLVDDES KPERRPTKHM PTPEQWTNVF 600
    NPAYAYYVYY CYANLYTLNK LRESKGMTTI KLRPHCGEAG DIDHLAAAFL 650
    TSHNIAHGVN LKKSPVLQYL YYLAQIGLAM SPLSNNSLFI DYHRNPFPTF 700
    FLRGLNVSLS TDDPLQIHLT KEPLVEEYSI AASLWKLSSC DLCEIARNSV 750
    YQSGFSHRLK SHWIGRNYYK RGHDGNDIHQ TNVPHIRIEF RHTIWKEEME 800
    LIHLRNVDIP EEIDR 815
    Length:815
    Mass (Da):93,854
    Last modified:June 1, 2003 - v1
    Checksum:iE9C9C55382961A7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004333 Genomic DNA. Translation: BAC75568.1.
    AK064333 mRNA. No translation available.
    AK102007 mRNA. No translation available.
    RefSeqiNP_001060730.1. NM_001067265.1.
    UniGeneiOs.8779.

    Genome annotation databases

    EnsemblPlantsiOS07T0693500-01; OS07T0693500-01; OS07G0693500.
    GeneIDi4344386.
    KEGGiosa:4344386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004333 Genomic DNA. Translation: BAC75568.1 .
    AK064333 mRNA. No translation available.
    AK102007 mRNA. No translation available.
    RefSeqi NP_001060730.1. NM_001067265.1.
    UniGenei Os.8779.

    3D structure databases

    ProteinModelPortali Q84NP7.
    SMRi Q84NP7. Positions 187-813.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q84NP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS07T0693500-01 ; OS07T0693500-01 ; OS07G0693500 .
    GeneIDi 4344386.
    KEGGi osa:4344386.

    Organism-specific databases

    Gramenei Q84NP7.

    Phylogenomic databases

    eggNOGi COG1816.
    HOGENOMi HOG000092200.
    KOi K01490.
    OMAi WTSEENP.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00663 .

    Family and domain databases

    InterProi IPR006650. A/AMP_deam_AS.
    IPR001365. A/AMP_deaminase_dom.
    IPR006329. AMPD.
    [Graphical view ]
    PANTHERi PTHR11359. PTHR11359. 1 hit.
    Pfami PF00962. A_deaminase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01429. AMP_deaminase. 1 hit.
    PROSITEi PS00485. A_DEAMINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiAMPD_ORYSJ
    AccessioniPrimary (citable) accession number: Q84NP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3