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Q84NP7

- AMPD_ORYSJ

UniProt

Q84NP7 - AMPD_ORYSJ

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Protein
Probable AMP deaminase
Gene
AMPD, Os07g0693500, LOC_Os07g49270, P0034A04.129
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

AMP deaminase plays a critical role in energy metabolism By similarity.

Catalytic activityi

AMP + H2O = IMP + NH3.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi367 – 3671Zinc; catalytic By similarity
Metal bindingi369 – 3691Zinc; catalytic By similarity
Binding sitei369 – 3691Substrate By similarity
Metal bindingi635 – 6351Zinc; catalytic By similarity
Binding sitei638 – 6381Substrate By similarity
Active sitei657 – 6571Proton acceptor By similarity
Metal bindingi712 – 7121Zinc; catalytic By similarity

GO - Molecular functioni

  1. AMP deaminase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00591; UER00663.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable AMP deaminase (EC:3.5.4.6)
Gene namesi
Name:AMPD
Ordered Locus Names:Os07g0693500, LOC_Os07g49270
ORF Names:P0034A04.129
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 7

Organism-specific databases

GrameneiQ84NP7.

Subcellular locationi

Membrane; Single-pass membrane protein
Note: Might be associated with the inner mitochondrial membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2723Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Probable AMP deaminase
PRO_0000238456Add
BLAST

Proteomic databases

PRIDEiQ84NP7.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ84NP7.
SMRiQ84NP7. Positions 187-813.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni438 – 4436Substrate binding By similarity
Regioni713 – 7164Substrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 6915Asp-rich
Add
BLAST
Compositional biasi125 – 1306Poly-Asp
Compositional biasi604 – 61613Tyr-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1816.
HOGENOMiHOG000092200.
KOiK01490.
OMAiWTSEENP.

Family and domain databases

InterProiIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
[Graphical view]
PANTHERiPTHR11359. PTHR11359. 1 hit.
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01429. AMP_deaminase. 1 hit.
PROSITEiPS00485. A_DEAMINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q84NP7-1 [UniParc]FASTAAdd to Basket

« Hide

MDSTYALHLA VATLLGASFA AASAYYMHRK TLDQLLRFAR SLDRDHRRRN    50
RHLLDADDDD DDDPPRDHDR RTTLPIPPGL PPLHTGREGK PIISPASTKR 100
VGPLVRPTTP RSPVPTVSAF ETIEDSDDDD ENIAPDAKNN AVSLLTNGTI 150
GSDPLPGKAS QNGDTKPVPS TNMIRSQSAT GSLHGAQHNP VAADILRKEP 200
EHETFSRINI TAVETPSPDE IEAYKVLQKC LELREKYMFR EEVAPWEKEI 250
ITDPSTPKPN PNPFYYEQQT KTEHHFEMVD GVIHVYPNKD AKERIYPVAD 300
ATTFFTDMHY ILRVLAAGDI RTVCYKRLNL LEQKFNLHLM VNADRELLAQ 350
KAAPHRDFYN VRKVDTHVHH SACMNQKHLL RFIKSKLRKE PDEVVIFRDG 400
TYLTLKEVFE SLDLTGYDLN VDLLDVHADK STFHRFDKFN LKYNPCGQSR 450
LREIFLKQDN LIQGRFLAEL TKEVFSDLEA SKYQMAEYRI SIYGRKKSEW 500
DQMASWIVNN ELYSENVVWL IQIPRIYNVY REMGTINSFQ NLLDNIFLPL 550
FEVTVDPASH PQLHVFLQQV VGLDLVDDES KPERRPTKHM PTPEQWTNVF 600
NPAYAYYVYY CYANLYTLNK LRESKGMTTI KLRPHCGEAG DIDHLAAAFL 650
TSHNIAHGVN LKKSPVLQYL YYLAQIGLAM SPLSNNSLFI DYHRNPFPTF 700
FLRGLNVSLS TDDPLQIHLT KEPLVEEYSI AASLWKLSSC DLCEIARNSV 750
YQSGFSHRLK SHWIGRNYYK RGHDGNDIHQ TNVPHIRIEF RHTIWKEEME 800
LIHLRNVDIP EEIDR 815
Length:815
Mass (Da):93,854
Last modified:June 1, 2003 - v1
Checksum:iE9C9C55382961A7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP004333 Genomic DNA. Translation: BAC75568.1.
AK064333 mRNA. No translation available.
AK102007 mRNA. No translation available.
RefSeqiNP_001060730.1. NM_001067265.1.
UniGeneiOs.8779.

Genome annotation databases

EnsemblPlantsiOS07T0693500-01; OS07T0693500-01; OS07G0693500.
GeneIDi4344386.
KEGGiosa:4344386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP004333 Genomic DNA. Translation: BAC75568.1 .
AK064333 mRNA. No translation available.
AK102007 mRNA. No translation available.
RefSeqi NP_001060730.1. NM_001067265.1.
UniGenei Os.8779.

3D structure databases

ProteinModelPortali Q84NP7.
SMRi Q84NP7. Positions 187-813.
ModBasei Search...

Proteomic databases

PRIDEi Q84NP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS07T0693500-01 ; OS07T0693500-01 ; OS07G0693500 .
GeneIDi 4344386.
KEGGi osa:4344386.

Organism-specific databases

Gramenei Q84NP7.

Phylogenomic databases

eggNOGi COG1816.
HOGENOMi HOG000092200.
KOi K01490.
OMAi WTSEENP.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00663 .

Family and domain databases

InterProi IPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMPD.
[Graphical view ]
PANTHERi PTHR11359. PTHR11359. 1 hit.
Pfami PF00962. A_deaminase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01429. AMP_deaminase. 1 hit.
PROSITEi PS00485. A_DEAMINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiAMPD_ORYSJ
AccessioniPrimary (citable) accession number: Q84NP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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