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Q84NP7 (AMPD_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable AMP deaminase

EC=3.5.4.6
Gene names
Name:AMPD
Ordered Locus Names:Os07g0693500, LOC_Os07g49270
ORF Names:P0034A04.129
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length815 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

AMP deaminase plays a critical role in energy metabolism By similarity.

Catalytic activity

AMP + H2O = IMP + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Membrane; Single-pass membrane protein. Note: Might be associated with the inner mitochondrial membrane By similarity.

Sequence similarities

Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processIMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionAMP deaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 815815Probable AMP deaminase
PRO_0000238456

Regions

Transmembrane5 – 2723Helical; Potential
Region438 – 4436Substrate binding By similarity
Region713 – 7164Substrate binding By similarity
Compositional bias55 – 6915Asp-rich
Compositional bias125 – 1306Poly-Asp
Compositional bias604 – 61613Tyr-rich

Sites

Active site6571Proton acceptor By similarity
Metal binding3671Zinc; catalytic By similarity
Metal binding3691Zinc; catalytic By similarity
Metal binding6351Zinc; catalytic By similarity
Metal binding7121Zinc; catalytic By similarity
Binding site3691Substrate By similarity
Binding site6381Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q84NP7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E9C9C55382961A7F

FASTA81593,854
        10         20         30         40         50         60 
MDSTYALHLA VATLLGASFA AASAYYMHRK TLDQLLRFAR SLDRDHRRRN RHLLDADDDD 

        70         80         90        100        110        120 
DDDPPRDHDR RTTLPIPPGL PPLHTGREGK PIISPASTKR VGPLVRPTTP RSPVPTVSAF 

       130        140        150        160        170        180 
ETIEDSDDDD ENIAPDAKNN AVSLLTNGTI GSDPLPGKAS QNGDTKPVPS TNMIRSQSAT 

       190        200        210        220        230        240 
GSLHGAQHNP VAADILRKEP EHETFSRINI TAVETPSPDE IEAYKVLQKC LELREKYMFR 

       250        260        270        280        290        300 
EEVAPWEKEI ITDPSTPKPN PNPFYYEQQT KTEHHFEMVD GVIHVYPNKD AKERIYPVAD 

       310        320        330        340        350        360 
ATTFFTDMHY ILRVLAAGDI RTVCYKRLNL LEQKFNLHLM VNADRELLAQ KAAPHRDFYN 

       370        380        390        400        410        420 
VRKVDTHVHH SACMNQKHLL RFIKSKLRKE PDEVVIFRDG TYLTLKEVFE SLDLTGYDLN 

       430        440        450        460        470        480 
VDLLDVHADK STFHRFDKFN LKYNPCGQSR LREIFLKQDN LIQGRFLAEL TKEVFSDLEA 

       490        500        510        520        530        540 
SKYQMAEYRI SIYGRKKSEW DQMASWIVNN ELYSENVVWL IQIPRIYNVY REMGTINSFQ 

       550        560        570        580        590        600 
NLLDNIFLPL FEVTVDPASH PQLHVFLQQV VGLDLVDDES KPERRPTKHM PTPEQWTNVF 

       610        620        630        640        650        660 
NPAYAYYVYY CYANLYTLNK LRESKGMTTI KLRPHCGEAG DIDHLAAAFL TSHNIAHGVN 

       670        680        690        700        710        720 
LKKSPVLQYL YYLAQIGLAM SPLSNNSLFI DYHRNPFPTF FLRGLNVSLS TDDPLQIHLT 

       730        740        750        760        770        780 
KEPLVEEYSI AASLWKLSSC DLCEIARNSV YQSGFSHRLK SHWIGRNYYK RGHDGNDIHQ 

       790        800        810 
TNVPHIRIEF RHTIWKEEME LIHLRNVDIP EEIDR 

« Hide

References

[1]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP004333 Genomic DNA. Translation: BAC75568.1.
AK064333 mRNA. No translation available.
AK102007 mRNA. No translation available.
RefSeqNP_001060730.1. NM_001067265.1.
UniGeneOs.8779.

3D structure databases

ProteinModelPortalQ84NP7.
SMRQ84NP7. Positions 187-813.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ84NP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS07T0693500-01; OS07T0693500-01; OS07G0693500.
GeneID4344386.
KEGGosa:4344386.

Organism-specific databases

GrameneQ84NP7.

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHOG000092200.
KOK01490.
OMAWTSEENP.

Enzyme and pathway databases

UniPathwayUPA00591; UER00663.

Family and domain databases

InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006329. AMP_deaminase.
[Graphical view]
PANTHERPTHR11359. PTHR11359. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01429. AMP_deaminase. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPD_ORYSJ
AccessionPrimary (citable) accession number: Q84NP7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways