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Q84MA2

- IP5P1_ARATH

UniProt

Q84MA2 - IP5P1_ARATH

Protein

Type I inositol 1,4,5-trisphosphate 5-phosphatase 1

Gene

IP5P1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Seems to be involved in the abscisic acid (ABA) signaling pathway. Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but not toward Ins(1,4)P2 and Ins1P.2 Publications

    Catalytic activityi

    D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate.1 Publication
    1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.1 Publication

    GO - Molecular functioni

    1. inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
    2. inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
    3. inositol-polyphosphate 5-phosphatase activity Source: TAIR
    4. inositol trisphosphate phosphatase activity Source: TAIR

    GO - Biological processi

    1. abscisic acid-activated signaling pathway Source: UniProtKB-KW
    2. inositol phosphate dephosphorylation Source: TAIR
    3. inositol trisphosphate metabolic process Source: TAIR
    4. phosphatidylinositol dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Abscisic acid signaling pathway

    Enzyme and pathway databases

    BioCyciARA:AT1G34120-MONOMER.
    ARA:GQT-260-MONOMER.
    ARA:GQT-261-MONOMER.
    MetaCyc:AT1G34120-MONOMER.
    BRENDAi3.1.3.56. 399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type I inositol 1,4,5-trisphosphate 5-phosphatase 1 (EC:3.1.3.56)
    Short name:
    At5PTase1
    Gene namesi
    Name:IP5P1
    Synonyms:5P1
    Ordered Locus Names:At1g34120
    ORF Names:F12G12.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G34120.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 590590Type I inositol 1,4,5-trisphosphate 5-phosphatase 1PRO_0000209722Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei60 – 601Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ84MA2.
    PRIDEiQ84MA2.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously.1 Publication

    Inductioni

    Induced by ABA at both transcript and protein levels in a specific, transient manner.1 Publication

    Gene expression databases

    GenevestigatoriQ84MA2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ84MA2.
    SMRiQ84MA2. Positions 337-570.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni445 – 46016Catalytic 1Sequence AnalysisAdd
    BLAST
    Regioni523 – 53816Catalytic 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5411.
    HOGENOMiHOG000241161.
    InParanoidiQ84MA2.
    OMAiIRICAGT.
    PhylomeDBiQ84MA2.

    Family and domain databases

    Gene3Di3.60.10.10. 2 hits.
    InterProiIPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    [Graphical view]
    PfamiPF03372. Exo_endo_phos. 1 hit.
    [Graphical view]
    SMARTiSM00128. IPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q84MA2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEVRSRSRR TESNWATICC SAFSCLQLYW ARIVLRKWFN VSASESDYSA    50
    DSDDDYEDRS QEFDPISSGV TNPRVDTDGN VIYRPKLRRR NSETFRMQYI 100
    DTKAIRICAG TWNVGGRVPS SDLDIDGWLD TLEPADIYVL GLQEIVPLNA 150
    GNIFGMEDDQ PALEWENLIR DALNRVQPRK LKIKSHSDPP SPSKFKQPEE 200
    VPYSVEDMFV ETSHDACDGI SSMDNKLNSV ESTDVPIVSE DSLTNIDVLG 250
    STNDNASCLP IQEYLQRQFS TPNTPDRSLS MQINSDSKRE ERFSYTERVG 300
    LSWPEPPLRL LNQYVSERRG SFKSVNLTIT NLRKPSYVRI VSKQMVGVFL 350
    TIWVRRNLRK HISNLCVSTV GVGIMGYIGN KGSVSVSMSI YQTPFCFLCT 400
    HLSSGEKDTD QEKRNDDVRE IHRRTQFLPH SLNANELPRS ICNHERIIWL 450
    GDLNYRINLS YEKTHELIAR KEWQRLVEYD QLSREMTKGN LFEGWSEGTL 500
    DFAPTYKYEI DSENYIGDDP ESGKRRPAWC DRIIWNGKGM KLFNYRRNEI 550
    KLSDHRPVTA TFLAEVEVLS PRKLQHALTL TYAEIQGLDA 590
    Length:590
    Mass (Da):67,783
    Last modified:June 7, 2005 - v2
    Checksum:i53C31A05D4C04428
    GO
    Isoform 2 (identifier: Q84MA2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-83: GNVIY → D

    Note: May be due to a donor acceptor splice site.

    Show »
    Length:586
    Mass (Da):67,352
    Checksum:i3C116AA1EE16F359
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211S → L in AAG17824. (PubMed:11340187)Curated
    Sequence conflicti80 – 801N → D in AAD10828. 1 PublicationCurated
    Sequence conflicti239 – 2391S → G in AAD10828. 1 PublicationCurated
    Sequence conflicti478 – 4781E → K in AAD10828. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei79 – 835GNVIY → D in isoform 2. 3 PublicationsVSP_013848

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289633 mRNA. Translation: AAG17824.1.
    AF117062 mRNA. Translation: AAD10828.1.
    AC015446 Genomic DNA. Translation: AAG12525.1.
    CP002684 Genomic DNA. Translation: AEE31672.1.
    CP002684 Genomic DNA. Translation: AEE31674.1.
    BT006448 mRNA. Translation: AAP21256.1.
    AK227368 mRNA. Translation: BAE99376.1.
    PIRiC86465.
    RefSeqiNP_564437.1. NM_103135.3. [Q84MA2-2]
    NP_849745.1. NM_179414.1. [Q84MA2-1]
    UniGeneiAt.10999.
    At.73182.

    Genome annotation databases

    EnsemblPlantsiAT1G34120.2; AT1G34120.2; AT1G34120. [Q84MA2-1]
    GeneIDi840311.
    KEGGiath:AT1G34120.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289633 mRNA. Translation: AAG17824.1 .
    AF117062 mRNA. Translation: AAD10828.1 .
    AC015446 Genomic DNA. Translation: AAG12525.1 .
    CP002684 Genomic DNA. Translation: AEE31672.1 .
    CP002684 Genomic DNA. Translation: AEE31674.1 .
    BT006448 mRNA. Translation: AAP21256.1 .
    AK227368 mRNA. Translation: BAE99376.1 .
    PIRi C86465.
    RefSeqi NP_564437.1. NM_103135.3. [Q84MA2-2 ]
    NP_849745.1. NM_179414.1. [Q84MA2-1 ]
    UniGenei At.10999.
    At.73182.

    3D structure databases

    ProteinModelPortali Q84MA2.
    SMRi Q84MA2. Positions 337-570.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q84MA2.
    PRIDEi Q84MA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G34120.2 ; AT1G34120.2 ; AT1G34120 . [Q84MA2-1 ]
    GeneIDi 840311.
    KEGGi ath:AT1G34120.

    Organism-specific databases

    GeneFarmi 4925.
    TAIRi AT1G34120.

    Phylogenomic databases

    eggNOGi COG5411.
    HOGENOMi HOG000241161.
    InParanoidi Q84MA2.
    OMAi IRICAGT.
    PhylomeDBi Q84MA2.

    Enzyme and pathway databases

    BioCyci ARA:AT1G34120-MONOMER.
    ARA:GQT-260-MONOMER.
    ARA:GQT-261-MONOMER.
    MetaCyc:AT1G34120-MONOMER.
    BRENDAi 3.1.3.56. 399.

    Gene expression databases

    Genevestigatori Q84MA2.

    Family and domain databases

    Gene3Di 3.60.10.10. 2 hits.
    InterProi IPR005135. Endo/exonuclease/phosphatase.
    IPR000300. IPPc.
    [Graphical view ]
    Pfami PF03372. Exo_endo_phos. 1 hit.
    [Graphical view ]
    SMARTi SM00128. IPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Arabidopsis PLC1 is required for secondary responses to abscisic acid signals."
      Sanchez J.-P., Chua N.-H.
      Plant Cell 13:1143-1154(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: cv. Landsberg erecta.
    2. "Characterization of putative inositol (1,4,5)-trisphosphate/phosphatidylinositol (4,5)-bisphosphate 5-phosphatase cDNAs from Arabidopsis thaliana."
      Parzer M.S.A., de Vos S., van Lookeren Campagne M.M.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    6. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    7. "Molecular characterization of At5PTase1, an inositol phosphatase capable of terminating inositol trisphosphate signaling."
      Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.
      Plant Physiol. 126:801-810(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    8. "An Arabidopsis inositol 5-phosphatase gain-of-function alters abscisic acid signaling."
      Burnette R.N., Gunesekera B.M., Gillaspy G.E.
      Plant Physiol. 132:1011-1019(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    9. "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana."
      Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E., Rathjen J.P., Peck S.C.
      J. Proteomics 72:439-451(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: cv. Columbia.
    10. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
      Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
      Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIP5P1_ARATH
    AccessioniPrimary (citable) accession number: Q84MA2
    Secondary accession number(s): Q0WU22
    , Q9FUR3, Q9FX20, Q9ZSC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3