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Q84M93 (MPK17_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 17

Short name=AtMPK17
Short name=MAP kinase 17
EC=2.7.11.24
Gene names
Name:MPK17
Ordered Locus Names:At2g01450
ORF Names:F2I9.7
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAC67338.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Mitogen-activated protein kinase 17
PRO_0000245817

Regions

Domain16 – 307292Protein kinase
Nucleotide binding22 – 309ATP By similarity
Motif178 – 1803TXY

Sites

Active site1421Proton acceptor By similarity
Binding site451ATP By similarity

Amino acid modifications

Modified residue1781Phosphothreonine By similarity
Modified residue1801Phosphotyrosine By similarity
Modified residue1831Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q84M93 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2741BC52DC3FFCE6

FASTA48655,493
        10         20         30         40         50         60 
MLEKEFFTEY GEASQYQIQE VVGKGSYGVV ASAECPHTGG KVAIKKMTNV FEHVSDAIRI 

        70         80         90        100        110        120 
LREIKLLRLL RHPDIVEIKH IMLPPCRKEF KDIYVVFELM ESDLHHVLKV NDDLTPQHHQ 

       130        140        150        160        170        180 
FFLYQLLRGL KFMHSAHVFH RDLKPKNILA NADCKIKICD LGLARVSFTD SPSAVFWTDY 

       190        200        210        220        230        240 
VATRWYRAPE LCGSFYSNYT PAIDMWSVGC IFAEMLTGKP LFPGKNVVHQ LELVTDLLGT 

       250        260        270        280        290        300 
PSPITLSRIR NEKARKYLGN MRRKDPVPFT HKFPNIDPVA LKLLQRLIAF DPKDRPSAEE 

       310        320        330        340        350        360 
ALADPYFQGL ANVDYEPSRQ PISKLEFEFE RRKLTRDDVR ELMYREILEY HPQMLQEYLQ 

       370        380        390        400        410        420 
GEENINSHFL YPSGVDQFKQ EFARLEEHND DEEEHNSPPH QRKYTSLPRE RVCSSEDEGS 

       430        440        450        460        470        480 
DSVHAQSSSA SVVFTPPQTP NTATGLSSQK ASQVDKAATP VKRSACLMRS DSICASRCVG 


VSSAVS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Mitogen-activated protein kinase cascades in plants: a new nomenclature."
MAPK group
Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Ancient signals: comparative genomics of plant MAPK and MAPKK gene families."
Hamel L.P., Nicole M.C., Sritubtim S., Morency M.J., Ellis M., Ehlting J., Beaudoin N., Barbazuk B., Klessig D., Lee J., Martin G., Mundy J., Ohashi Y., Scheel D., Sheen J., Xing T., Zhang S., Seguin A., Ellis B.E.
Trends Plant Sci. 11:192-198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005560 Genomic DNA. Translation: AAC67338.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC05452.1.
CP002685 Genomic DNA. Translation: AEC05453.1.
CP002685 Genomic DNA. Translation: AEC05454.1.
CP002685 Genomic DNA. Translation: AEC05455.1.
BT006469 mRNA. Translation: AAP21277.1.
PIRH84424.
RefSeqNP_001030939.1. NM_001035862.2.
NP_001030940.1. NM_001035863.1.
NP_001030941.1. NM_001035864.1.
NP_178254.2. NM_126206.3.
UniGeneAt.20212.

3D structure databases

ProteinModelPortalQ84M93.
SMRQ84M93. Positions 15-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ84M93. 2 interactions.

Proteomic databases

PRIDEQ84M93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G01450.1; AT2G01450.1; AT2G01450.
AT2G01450.2; AT2G01450.2; AT2G01450.
AT2G01450.3; AT2G01450.3; AT2G01450.
AT2G01450.4; AT2G01450.4; AT2G01450.
GeneID814673.
KEGGath:AT2G01450.

Organism-specific databases

GeneFarm870. 89.
TAIRAT2G01450.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
InParanoidQ84M93.
KOK00924.
OMAADANKTH.
PhylomeDBQ84M93.

Enzyme and pathway databases

BioCycARA:AT2G01450-MONOMER.
ARA:GQT-1826-MONOMER.
ARA:GQT-1827-MONOMER.
ARA:GQT-1828-MONOMER.

Gene expression databases

ArrayExpressQ84M93.
GenevestigatorQ84M93.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPK17_ARATH
AccessionPrimary (citable) accession number: Q84M93
Secondary accession number(s): Q9ZVF9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names