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Q84M93

- MPK17_ARATH

UniProt

Q84M93 - MPK17_ARATH

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Protein

Mitogen-activated protein kinase 17

Gene

MPK17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotation
Active sitei142 – 1421Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: TAIR
  3. protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  1. MAPK cascade Source: GOC
  2. protein autophosphorylation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G01450-MONOMER.
ARA:GQT-1826-MONOMER.
ARA:GQT-1827-MONOMER.
ARA:GQT-1828-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 17 (EC:2.7.11.24)
Short name:
AtMPK17
Short name:
MAP kinase 17
Gene namesi
Name:MPK17
Ordered Locus Names:At2g01450
ORF Names:F2I9.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G01450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Mitogen-activated protein kinase 17PRO_0000245817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781PhosphothreonineBy similarity
Modified residuei180 – 1801PhosphotyrosineBy similarity
Modified residuei183 – 1831PhosphothreonineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ84M93.

Expressioni

Gene expression databases

ExpressionAtlasiQ84M93. baseline and differential.
GenevestigatoriQ84M93.

Interactioni

Protein-protein interaction databases

IntActiQ84M93. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ84M93.
SMRiQ84M93. Positions 15-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 307292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi178 – 1803TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ84M93.
KOiK00924.
OMAiADANKTH.
PhylomeDBiQ84M93.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q84M93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEKEFFTEY GEASQYQIQE VVGKGSYGVV ASAECPHTGG KVAIKKMTNV
60 70 80 90 100
FEHVSDAIRI LREIKLLRLL RHPDIVEIKH IMLPPCRKEF KDIYVVFELM
110 120 130 140 150
ESDLHHVLKV NDDLTPQHHQ FFLYQLLRGL KFMHSAHVFH RDLKPKNILA
160 170 180 190 200
NADCKIKICD LGLARVSFTD SPSAVFWTDY VATRWYRAPE LCGSFYSNYT
210 220 230 240 250
PAIDMWSVGC IFAEMLTGKP LFPGKNVVHQ LELVTDLLGT PSPITLSRIR
260 270 280 290 300
NEKARKYLGN MRRKDPVPFT HKFPNIDPVA LKLLQRLIAF DPKDRPSAEE
310 320 330 340 350
ALADPYFQGL ANVDYEPSRQ PISKLEFEFE RRKLTRDDVR ELMYREILEY
360 370 380 390 400
HPQMLQEYLQ GEENINSHFL YPSGVDQFKQ EFARLEEHND DEEEHNSPPH
410 420 430 440 450
QRKYTSLPRE RVCSSEDEGS DSVHAQSSSA SVVFTPPQTP NTATGLSSQK
460 470 480
ASQVDKAATP VKRSACLMRS DSICASRCVG VSSAVS
Length:486
Mass (Da):55,493
Last modified:June 1, 2003 - v1
Checksum:i2741BC52DC3FFCE6
GO

Sequence cautioni

The sequence AAC67338.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005560 Genomic DNA. Translation: AAC67338.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC05452.1.
CP002685 Genomic DNA. Translation: AEC05453.1.
CP002685 Genomic DNA. Translation: AEC05454.1.
CP002685 Genomic DNA. Translation: AEC05455.1.
BT006469 mRNA. Translation: AAP21277.1.
PIRiH84424.
RefSeqiNP_001030939.1. NM_001035862.2.
NP_001030940.1. NM_001035863.1.
NP_001030941.1. NM_001035864.1.
NP_178254.2. NM_126206.3.
UniGeneiAt.20212.

Genome annotation databases

EnsemblPlantsiAT2G01450.1; AT2G01450.1; AT2G01450.
AT2G01450.2; AT2G01450.2; AT2G01450.
AT2G01450.3; AT2G01450.3; AT2G01450.
AT2G01450.4; AT2G01450.4; AT2G01450.
GeneIDi814673.
KEGGiath:AT2G01450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005560 Genomic DNA. Translation: AAC67338.1 . Sequence problems.
CP002685 Genomic DNA. Translation: AEC05452.1 .
CP002685 Genomic DNA. Translation: AEC05453.1 .
CP002685 Genomic DNA. Translation: AEC05454.1 .
CP002685 Genomic DNA. Translation: AEC05455.1 .
BT006469 mRNA. Translation: AAP21277.1 .
PIRi H84424.
RefSeqi NP_001030939.1. NM_001035862.2.
NP_001030940.1. NM_001035863.1.
NP_001030941.1. NM_001035864.1.
NP_178254.2. NM_126206.3.
UniGenei At.20212.

3D structure databases

ProteinModelPortali Q84M93.
SMRi Q84M93. Positions 15-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q84M93. 2 interactions.

Proteomic databases

PRIDEi Q84M93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G01450.1 ; AT2G01450.1 ; AT2G01450 .
AT2G01450.2 ; AT2G01450.2 ; AT2G01450 .
AT2G01450.3 ; AT2G01450.3 ; AT2G01450 .
AT2G01450.4 ; AT2G01450.4 ; AT2G01450 .
GeneIDi 814673.
KEGGi ath:AT2G01450.

Organism-specific databases

GeneFarmi 870. 89.
TAIRi AT2G01450.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q84M93.
KOi K00924.
OMAi ADANKTH.
PhylomeDBi Q84M93.

Enzyme and pathway databases

BioCyci ARA:AT2G01450-MONOMER.
ARA:GQT-1826-MONOMER.
ARA:GQT-1827-MONOMER.
ARA:GQT-1828-MONOMER.

Gene expression databases

ExpressionAtlasi Q84M93. baseline and differential.
Genevestigatori Q84M93.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
    MAPK group
    Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. Cited for: GENE FAMILY.

Entry informationi

Entry nameiMPK17_ARATH
AccessioniPrimary (citable) accession number: Q84M93
Secondary accession number(s): Q9ZVF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3