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Q84M93

- MPK17_ARATH

UniProt

Q84M93 - MPK17_ARATH

Protein

Mitogen-activated protein kinase 17

Gene

MPK17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451ATPPROSITE-ProRule annotation
    Active sitei142 – 1421Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: TAIR
    3. protein serine/threonine kinase activity Source: TAIR

    GO - Biological processi

    1. MAPK cascade Source: GOC
    2. protein autophosphorylation Source: TAIR

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G01450-MONOMER.
    ARA:GQT-1826-MONOMER.
    ARA:GQT-1827-MONOMER.
    ARA:GQT-1828-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 17 (EC:2.7.11.24)
    Short name:
    AtMPK17
    Short name:
    MAP kinase 17
    Gene namesi
    Name:MPK17
    Ordered Locus Names:At2g01450
    ORF Names:F2I9.7
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G01450.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Mitogen-activated protein kinase 17PRO_0000245817Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei178 – 1781PhosphothreonineBy similarity
    Modified residuei180 – 1801PhosphotyrosineBy similarity
    Modified residuei183 – 1831PhosphothreonineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ84M93.

    Expressioni

    Gene expression databases

    ArrayExpressiQ84M93.
    GenevestigatoriQ84M93.

    Interactioni

    Protein-protein interaction databases

    IntActiQ84M93. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ84M93.
    SMRiQ84M93. Positions 15-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 307292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi178 – 1803TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    InParanoidiQ84M93.
    KOiK00924.
    OMAiADANKTH.
    PhylomeDBiQ84M93.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q84M93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEKEFFTEY GEASQYQIQE VVGKGSYGVV ASAECPHTGG KVAIKKMTNV    50
    FEHVSDAIRI LREIKLLRLL RHPDIVEIKH IMLPPCRKEF KDIYVVFELM 100
    ESDLHHVLKV NDDLTPQHHQ FFLYQLLRGL KFMHSAHVFH RDLKPKNILA 150
    NADCKIKICD LGLARVSFTD SPSAVFWTDY VATRWYRAPE LCGSFYSNYT 200
    PAIDMWSVGC IFAEMLTGKP LFPGKNVVHQ LELVTDLLGT PSPITLSRIR 250
    NEKARKYLGN MRRKDPVPFT HKFPNIDPVA LKLLQRLIAF DPKDRPSAEE 300
    ALADPYFQGL ANVDYEPSRQ PISKLEFEFE RRKLTRDDVR ELMYREILEY 350
    HPQMLQEYLQ GEENINSHFL YPSGVDQFKQ EFARLEEHND DEEEHNSPPH 400
    QRKYTSLPRE RVCSSEDEGS DSVHAQSSSA SVVFTPPQTP NTATGLSSQK 450
    ASQVDKAATP VKRSACLMRS DSICASRCVG VSSAVS 486
    Length:486
    Mass (Da):55,493
    Last modified:June 1, 2003 - v1
    Checksum:i2741BC52DC3FFCE6
    GO

    Sequence cautioni

    The sequence AAC67338.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005560 Genomic DNA. Translation: AAC67338.1. Sequence problems.
    CP002685 Genomic DNA. Translation: AEC05452.1.
    CP002685 Genomic DNA. Translation: AEC05453.1.
    CP002685 Genomic DNA. Translation: AEC05454.1.
    CP002685 Genomic DNA. Translation: AEC05455.1.
    BT006469 mRNA. Translation: AAP21277.1.
    PIRiH84424.
    RefSeqiNP_001030939.1. NM_001035862.2.
    NP_001030940.1. NM_001035863.1.
    NP_001030941.1. NM_001035864.1.
    NP_178254.2. NM_126206.3.
    UniGeneiAt.20212.

    Genome annotation databases

    EnsemblPlantsiAT2G01450.1; AT2G01450.1; AT2G01450.
    AT2G01450.2; AT2G01450.2; AT2G01450.
    AT2G01450.3; AT2G01450.3; AT2G01450.
    AT2G01450.4; AT2G01450.4; AT2G01450.
    GeneIDi814673.
    KEGGiath:AT2G01450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005560 Genomic DNA. Translation: AAC67338.1 . Sequence problems.
    CP002685 Genomic DNA. Translation: AEC05452.1 .
    CP002685 Genomic DNA. Translation: AEC05453.1 .
    CP002685 Genomic DNA. Translation: AEC05454.1 .
    CP002685 Genomic DNA. Translation: AEC05455.1 .
    BT006469 mRNA. Translation: AAP21277.1 .
    PIRi H84424.
    RefSeqi NP_001030939.1. NM_001035862.2.
    NP_001030940.1. NM_001035863.1.
    NP_001030941.1. NM_001035864.1.
    NP_178254.2. NM_126206.3.
    UniGenei At.20212.

    3D structure databases

    ProteinModelPortali Q84M93.
    SMRi Q84M93. Positions 15-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q84M93. 2 interactions.

    Proteomic databases

    PRIDEi Q84M93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G01450.1 ; AT2G01450.1 ; AT2G01450 .
    AT2G01450.2 ; AT2G01450.2 ; AT2G01450 .
    AT2G01450.3 ; AT2G01450.3 ; AT2G01450 .
    AT2G01450.4 ; AT2G01450.4 ; AT2G01450 .
    GeneIDi 814673.
    KEGGi ath:AT2G01450.

    Organism-specific databases

    GeneFarmi 870. 89.
    TAIRi AT2G01450.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    InParanoidi Q84M93.
    KOi K00924.
    OMAi ADANKTH.
    PhylomeDBi Q84M93.

    Enzyme and pathway databases

    BioCyci ARA:AT2G01450-MONOMER.
    ARA:GQT-1826-MONOMER.
    ARA:GQT-1827-MONOMER.
    ARA:GQT-1828-MONOMER.

    Gene expression databases

    ArrayExpressi Q84M93.
    Genevestigatori Q84M93.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
      MAPK group
      Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiMPK17_ARATH
    AccessioniPrimary (citable) accession number: Q84M93
    Secondary accession number(s): Q9ZVF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3