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Protein

Mitogen-activated protein kinase 17

Gene

MPK17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotation1
Active sitei142Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  • positive regulation of peroxisome organization Source: TAIR
  • protein autophosphorylation Source: TAIR
  • regulation of gene expression Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-4086398 Ca2+ pathway
R-ATH-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 17 (EC:2.7.11.24)
Short name:
AtMPK17
Short name:
MAP kinase 17
Gene namesi
Name:MPK17
Ordered Locus Names:At2g01450
ORF Names:F2I9.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G01450
TAIRilocus:2049552 AT2G01450

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458171 – 486Mitogen-activated protein kinase 17Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphothreonineBy similarity1
Modified residuei180PhosphotyrosineBy similarity1
Modified residuei183PhosphothreonineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-178 and Tyr-180, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ84M93

PTM databases

iPTMnetiQ84M93

Expressioni

Gene expression databases

ExpressionAtlasiQ84M93 baseline and differential
GenevisibleiQ84M93 AT

Interactioni

Protein-protein interaction databases

BioGridi76, 1 interactor
IntActiQ84M93, 2 interactors
STRINGi3702.AT2G01450.1

Structurei

3D structure databases

ProteinModelPortaliQ84M93
SMRiQ84M93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 307Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi178 – 180TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
HOGENOMiHOG000233024
InParanoidiQ84M93
OMAiLEEHNDD
OrthoDBiEOG093605CF
PhylomeDBiQ84M93

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q84M93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEKEFFTEY GEASQYQIQE VVGKGSYGVV ASAECPHTGG KVAIKKMTNV
60 70 80 90 100
FEHVSDAIRI LREIKLLRLL RHPDIVEIKH IMLPPCRKEF KDIYVVFELM
110 120 130 140 150
ESDLHHVLKV NDDLTPQHHQ FFLYQLLRGL KFMHSAHVFH RDLKPKNILA
160 170 180 190 200
NADCKIKICD LGLARVSFTD SPSAVFWTDY VATRWYRAPE LCGSFYSNYT
210 220 230 240 250
PAIDMWSVGC IFAEMLTGKP LFPGKNVVHQ LELVTDLLGT PSPITLSRIR
260 270 280 290 300
NEKARKYLGN MRRKDPVPFT HKFPNIDPVA LKLLQRLIAF DPKDRPSAEE
310 320 330 340 350
ALADPYFQGL ANVDYEPSRQ PISKLEFEFE RRKLTRDDVR ELMYREILEY
360 370 380 390 400
HPQMLQEYLQ GEENINSHFL YPSGVDQFKQ EFARLEEHND DEEEHNSPPH
410 420 430 440 450
QRKYTSLPRE RVCSSEDEGS DSVHAQSSSA SVVFTPPQTP NTATGLSSQK
460 470 480
ASQVDKAATP VKRSACLMRS DSICASRCVG VSSAVS
Length:486
Mass (Da):55,493
Last modified:June 1, 2003 - v1
Checksum:i2741BC52DC3FFCE6
GO

Sequence cautioni

The sequence AAC67338 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005560 Genomic DNA Translation: AAC67338.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC05452.1
CP002685 Genomic DNA Translation: AEC05453.1
CP002685 Genomic DNA Translation: AEC05454.1
CP002685 Genomic DNA Translation: AEC05455.1
BT006469 mRNA Translation: AAP21277.1
PIRiH84424
RefSeqiNP_001030939.1, NM_001035862.2
NP_001030940.1, NM_001035863.1
NP_001030941.1, NM_001035864.1
NP_178254.2, NM_126206.4
UniGeneiAt.20212

Genome annotation databases

EnsemblPlantsiAT2G01450.1; AT2G01450.1; AT2G01450
AT2G01450.2; AT2G01450.2; AT2G01450
AT2G01450.3; AT2G01450.3; AT2G01450
AT2G01450.4; AT2G01450.4; AT2G01450
GeneIDi814673
GrameneiAT2G01450.1; AT2G01450.1; AT2G01450
AT2G01450.2; AT2G01450.2; AT2G01450
AT2G01450.3; AT2G01450.3; AT2G01450
AT2G01450.4; AT2G01450.4; AT2G01450
KEGGiath:AT2G01450

Similar proteinsi

Entry informationi

Entry nameiMPK17_ARATH
AccessioniPrimary (citable) accession number: Q84M93
Secondary accession number(s): Q9ZVF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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