Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin receptor RAD23c

Gene

RAD23C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).By similarity2 Publications

GO - Molecular functioni

  • damaged DNA binding Source: InterPro
  • polyubiquitin modification-dependent protein binding Source: UniProtKB
  • proteasome binding Source: TAIR
  • ubiquitin binding Source: TAIR

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-ATH-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-ATH-5689877 Josephin domain DUBs
R-ATH-5696394 DNA Damage Recognition in GG-NER
R-ATH-5696395 Formation of Incision Complex in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin receptor RAD23c
Short name:
AtRAD23c
Alternative name(s):
Putative DNA repair protein RAD23-3
RAD23-like protein 3
Short name:
AtRAD23-3
Gene namesi
Name:RAD23C
Synonyms:RAD23, RAD23-3
Ordered Locus Names:At3g02540
ORF Names:F16B3.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G02540
TAIRilocus:2076944 AT3G02540

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi8L → A: Abolishes interaction with RPN10. 1 Publication1
Mutagenesisi47I → A: Abolishes interaction with RPN10. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149101 – 419Ubiquitin receptor RAD23cAdd BLAST419

Proteomic databases

PaxDbiQ84L31
PRIDEiQ84L31

PTM databases

iPTMnetiQ84L31

Expressioni

Tissue specificityi

Widely expressed in the whole plant.1 Publication

Gene expression databases

ExpressionAtlasiQ84L31 differential
GenevisibleiQ84L31 AT

Interactioni

Subunit structurei

Interacts with 'Lys-48'-linked polyubiquitin chains via its both UBA domains. Interacts with RPN10 via its ubiquitin-like domain.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UBCP0CG482EBI-4437395,EBI-3390054From Homo sapiens.

GO - Molecular functioni

  • polyubiquitin modification-dependent protein binding Source: UniProtKB
  • ubiquitin binding Source: TAIR

Protein-protein interaction databases

BioGridi6528, 3 interactors
DIPiDIP-57199N
IntActiQ84L31, 6 interactors
MINTiQ84L31
STRINGi3702.AT3G02540.1

Structurei

3D structure databases

ProteinModelPortaliQ84L31
SMRiQ84L31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 79Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini185 – 228UBA 1PROSITE-ProRule annotationAdd BLAST44
Domaini288 – 331STI1Add BLAST44
Domaini372 – 413UBA 2PROSITE-ProRule annotationAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 166Pro-richAdd BLAST69

Sequence similaritiesi

Belongs to the RAD23 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0011 Eukaryota
COG5272 LUCA
HOGENOMiHOG000172162
InParanoidiQ84L31
KOiK10839
OMAiKGRDAFP
OrthoDBiEOG09360ED8
PhylomeDBiQ84L31

Family and domain databases

Gene3Di1.10.10.540, 1 hit
InterProiView protein in InterPro
IPR004806 Rad23
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR015360 XPC-bd
IPR036353 XPC-bd_sf
PfamiView protein in Pfam
PF00627 UBA, 2 hits
PF00240 ubiquitin, 1 hit
PF09280 XPC-binding, 1 hit
PRINTSiPR01839 RAD23PROTEIN
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00165 UBA, 2 hits
SM00213 UBQ, 1 hit
SUPFAMiSSF101238 SSF101238, 1 hit
SSF46934 SSF46934, 2 hits
SSF54236 SSF54236, 1 hit
TIGRFAMsiTIGR00601 rad23, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits
PS50053 UBIQUITIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q84L31-1) [UniParc]FASTAAdd to basket
Also known as: alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIFVKTLKG THFEIEVKPE DSVVDVKKNI ESVQGADVYP AAKQMLIHQG
60 70 80 90 100
KVLKDETTIE ENKVAENSFI VIMMNKSKPA SAAASSASAG TSQAKSIPPS
110 120 130 140 150
TSQPSISPQT PASVSAPVAP APTRPPPPAP TPTPAPVAAT ETVTTPIPEP
160 170 180 190 200
VPATISSSTP APDSAPVGSQ GDVYGQAASN LAAGSNLEST IQQILDMGGG
210 220 230 240 250
TWDRETVVLA LRAAFNNPER AVEYLYTGIP EQAEVPPVAR PPASAGQPAN
260 270 280 290 300
PPAQTQQPAA APASGPNANP LDLFPQGLPN VGGNPGAGTL DFLRNSQQFQ
310 320 330 340 350
ALRAMVQANP QVLQPMLQEL GKQNPNLMRL IQDHQADFLR LINEPVEGGG
360 370 380 390 400
ESGNLLGQMA AGMPQPQAIQ VTHEEREAIE RLEAMGFERA LVLEVFFACN
410
KNEELAANYL LDHMHEFEE
Length:419
Mass (Da):44,247
Last modified:November 23, 2004 - v2
Checksum:iCAA13BC4FFEB1E25
GO
Isoform 2 (identifier: Q84L31-2) [UniParc]FASTAAdd to basket
Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     58-139: Missing.

Show »
Length:337
Mass (Da):36,221
Checksum:i6770375BB22527A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01187658 – 139Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109196 mRNA Translation: BAC76392.1
AB109197 mRNA Translation: BAC76393.1
AC021640 Genomic DNA Translation: AAF32461.1
CP002686 Genomic DNA Translation: AEE73824.1
AY039562 mRNA Translation: AAK62617.1
AY113034 mRNA Translation: AAM47342.1
RefSeqiNP_186903.1, NM_111121.4 [Q84L31-1]
UniGeneiAt.21477

Genome annotation databases

EnsemblPlantsiAT3G02540.1; AT3G02540.1; AT3G02540 [Q84L31-1]
AT3G02540.2; AT3G02540.2; AT3G02540
GeneIDi821195
GrameneiAT3G02540.1; AT3G02540.1; AT3G02540 [Q84L31-1]
AT3G02540.2; AT3G02540.2; AT3G02540
KEGGiath:AT3G02540

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRD23C_ARATH
AccessioniPrimary (citable) accession number: Q84L31
Secondary accession number(s): Q9M887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health