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Protein

Homeobox protein knotted-1-like 6

Gene

KNAT6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1, CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi245 – 30864Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • meristem maintenance Source: TAIR
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein knotted-1-like 6
Alternative name(s):
Protein KNAT6
Gene namesi
Name:KNAT6
Ordered Locus Names:At1g23380
ORF Names:F26F24.25, F28C11.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G23380.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Homeobox protein knotted-1-like 6PRO_0000311818Add
BLAST

Proteomic databases

PaxDbiQ84JS6.
PRIDEiQ84JS6.

PTM databases

iPTMnetiQ84JS6.

Expressioni

Tissue specificityi

Expressed predominantly in shoot apices of seedlings, and, to a lower extent, in rosette leaves.1 Publication

Developmental stagei

First detected in torpedo stage embryos at the boundaries between the presumptive SAM and the cotyledons. Later expressed between the cotyledons and the meristem, and between the cotyledons. In seedlings, localised in stipules and at the boundaries between the SAM and the emerging primordia. Expressed at the site of lateral roots.1 Publication

Inductioni

Seems to be repressed by AS2 and AS1 but induced by STM, CUC1 and CUC2.2 Publications

Gene expression databases

GenevisibleiQ84JS6. AT.

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/BELL protein BLH9/PNY. Interacts with OFP2 and OFP4.2 Publications

Protein-protein interaction databases

BioGridi24185. 15 interactions.
IntActiQ84JS6. 15 interactions.
STRINGi3702.AT1G23380.2.

Structurei

3D structure databases

ProteinModelPortaliQ84JS6.
SMRiQ84JS6. Positions 245-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini224 – 24421ELKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TALE/KNOX homeobox family.PROSITE-ProRule annotation
Contains 1 ELK domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000272741.
InParanoidiQ84JS6.
OMAiLMMSPES.
PhylomeDBiQ84JS6.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005539. ELK_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR005540. KNOX1.
IPR005541. KNOX2.
[Graphical view]
PfamiPF03789. ELK. 1 hit.
PF05920. Homeobox_KN. 1 hit.
PF03790. KNOX1. 1 hit.
PF03791. KNOX2. 1 hit.
[Graphical view]
SMARTiSM01188. ELK. 1 hit.
SM00389. HOX. 1 hit.
SM01255. KNOX1. 1 hit.
SM01256. KNOX2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51213. ELK. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform KNAT6S (identifier: Q84JS6-1) [UniParc]FASTAAdd to basket
Also known as: short

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGMYNFHSA GDYSDKSVLM MSPESLMFPS DYQALLCSSA GENRVSDVFG
60 70 80 90 100
SDELLSVAVS ALSSEAASIA PEIRRNDDNV SLTVIKAKIA CHPSYPRLLQ
110 120 130 140 150
AYIDCQKVGA PPEIACLLEE IQRESDVYKQ EVVPSSCFGA DPELDEFMET
160 170 180 190 200
YCDILVKYKS DLARPFDEAT CFLNKIEMQL RNLCTGVESA RGVSEDGVIS
210 220 230 240 250
SDEELSGGDH EVAEDGRQRC EDRDLKDRLL RKFGSRISTL KLEFSKKKKK
260 270 280 290 300
GKLPREARQA LLDWWNLHYK WPYPTEGDKI ALADATGLDQ KQINNWFINQ
310 320
RKRHWKPSEN MPFAMMDDSS GSFFTEE
Length:327
Mass (Da):36,934
Last modified:June 1, 2003 - v1
Checksum:i71147EAD25CD2908
GO
Isoform KNAT6L (identifier: Q84JS6-2) [UniParc]FASTAAdd to basket
Also known as: long

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: K → KKQ

Show »
Length:329
Mass (Da):37,190
Checksum:iCF8B7F527A6BAEE8
GO

Sequence cautioni

The sequence AAF79598 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF79598 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAF87007 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 1071K → KKQ in isoform KNAT6L. 1 PublicationVSP_029601

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005292 Genomic DNA. Translation: AAF87007.1. Different initiation.
AC007945 Genomic DNA. Translation: AAF79598.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30380.1.
CP002684 Genomic DNA. Translation: AEE30381.1.
BT002930 mRNA. Translation: AAO22744.1.
BT004370 mRNA. Translation: AAO42364.1.
AB072361 mRNA. Translation: BAB69678.1.
AB072362 mRNA. Translation: BAB69679.1.
RefSeqiNP_173752.3. NM_102187.4. [Q84JS6-2]
NP_850951.2. NM_180620.2. [Q84JS6-1]
UniGeneiAt.26286.

Genome annotation databases

EnsemblPlantsiAT1G23380.1; AT1G23380.1; AT1G23380. [Q84JS6-1]
GeneIDi838946.
KEGGiath:AT1G23380.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005292 Genomic DNA. Translation: AAF87007.1. Different initiation.
AC007945 Genomic DNA. Translation: AAF79598.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30380.1.
CP002684 Genomic DNA. Translation: AEE30381.1.
BT002930 mRNA. Translation: AAO22744.1.
BT004370 mRNA. Translation: AAO42364.1.
AB072361 mRNA. Translation: BAB69678.1.
AB072362 mRNA. Translation: BAB69679.1.
RefSeqiNP_173752.3. NM_102187.4. [Q84JS6-2]
NP_850951.2. NM_180620.2. [Q84JS6-1]
UniGeneiAt.26286.

3D structure databases

ProteinModelPortaliQ84JS6.
SMRiQ84JS6. Positions 245-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24185. 15 interactions.
IntActiQ84JS6. 15 interactions.
STRINGi3702.AT1G23380.2.

PTM databases

iPTMnetiQ84JS6.

Proteomic databases

PaxDbiQ84JS6.
PRIDEiQ84JS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G23380.1; AT1G23380.1; AT1G23380. [Q84JS6-1]
GeneIDi838946.
KEGGiath:AT1G23380.

Organism-specific databases

TAIRiAT1G23380.

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
HOGENOMiHOG000272741.
InParanoidiQ84JS6.
OMAiLMMSPES.
PhylomeDBiQ84JS6.

Miscellaneous databases

PROiQ84JS6.

Gene expression databases

GenevisibleiQ84JS6. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005539. ELK_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR005540. KNOX1.
IPR005541. KNOX2.
[Graphical view]
PfamiPF03789. ELK. 1 hit.
PF05920. Homeobox_KN. 1 hit.
PF03790. KNOX1. 1 hit.
PF03791. KNOX2. 1 hit.
[Graphical view]
SMARTiSM01188. ELK. 1 hit.
SM00389. HOX. 1 hit.
SM01255. KNOX1. 1 hit.
SM01256. KNOX2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51213. ELK. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKNAT6_ARATH
AccessioniPrimary (citable) accession number: Q84JS6
Secondary accession number(s): Q948K0, Q9LQD4, Q9LR21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.