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Q84JD5

- P2C68_ARATH

UniProt

Q84JD5 - P2C68_ARATH

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Protein

Probable protein phosphatase 2C 68

Gene

At5g06750

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Manganese 1By similarity
Metal bindingi87 – 871Manganese 2By similarity
Metal bindingi88 – 881Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi291 – 2911Manganese 2By similarity
Metal bindingi350 – 3501Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G06750-MONOMER.
ARA:GQT-993-MONOMER.
ARA:GQT-994-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 68 (EC:3.1.3.16)
Short name:
AtPP2C68
Gene namesi
Ordered Locus Names:At5g06750
ORF Names:MPH15.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G06750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Probable protein phosphatase 2C 68PRO_0000367989Add
BLAST

Proteomic databases

PaxDbiQ84JD5.
PRIDEiQ84JD5.

Expressioni

Gene expression databases

GenevestigatoriQ84JD5.

Interactioni

Protein-protein interaction databases

BioGridi15843. 1 interaction.
IntActiQ84JD5. 1 interaction.
MINTiMINT-8390464.

Structurei

3D structure databases

ProteinModelPortaliQ84JD5.
SMRiQ84JD5. Positions 82-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 331250PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 3511Poly-AspAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000238703.
InParanoidiQ84JD5.
OMAiTVVVVYI.
PhylomeDBiQ84JD5.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q84JD5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSWLARMAL FCLRPMRRYG RMNRDDDDDD DHDGDSSSSG DSLLWSRELE
60 70 80 90 100
RHSFGDFSIA VVQANEVIED HSQVETGNGA VFVGVYDGHG GPEASRYISD
110 120 130 140 150
HLFSHLMRVS RERSCISEEA LRAAFSATEE GFLTLVRRTC GLKPLIAAVG
160 170 180 190 200
SCCLVGVIWK GTLLIANVGD SRAVLGSMGS NNNRSNKIVA EQLTSDHNAA
210 220 230 240 250
LEEVRQELRS LHPDDSHIVV LKHGVWRIKG IIQVSRSIGD AYLKRPEFSL
260 270 280 290 300
DPSFPRFHLA EELQRPVLSA EPCVYTRVLQ TSDKFVIFAS DGLWEQMTNQ
310 320 330 340 350
QAVEIVNKHP RPGIARRLVR RAITIAAKKR EMNYDDLKKV ERGVRRFFHD
360 370 380 390
DITVVVIFID NELLMVEKAT VPELSIKGFS HTVGPSKFSI FLS
Length:393
Mass (Da):44,140
Last modified:June 1, 2003 - v1
Checksum:iCAB959A38511D7B8
GO

Sequence cautioni

The sequence BAB09809.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti268 – 2681L → S in AAM61277. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002032 Genomic DNA. Translation: BAB09809.1. Different initiation.
CP002688 Genomic DNA. Translation: AED91058.1.
CP002688 Genomic DNA. Translation: AED91060.1.
BT004178 mRNA. Translation: AAO42197.1.
BT005462 mRNA. Translation: AAO63882.1.
AY084703 mRNA. Translation: AAM61277.1.
RefSeqiNP_001119181.1. NM_001125709.1. [Q84JD5-1]
NP_568174.1. NM_120758.3. [Q84JD5-1]
UniGeneiAt.32818.

Genome annotation databases

EnsemblPlantsiAT5G06750.1; AT5G06750.1; AT5G06750. [Q84JD5-1]
AT5G06750.3; AT5G06750.3; AT5G06750. [Q84JD5-1]
GeneIDi830564.
KEGGiath:AT5G06750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002032 Genomic DNA. Translation: BAB09809.1 . Different initiation.
CP002688 Genomic DNA. Translation: AED91058.1 .
CP002688 Genomic DNA. Translation: AED91060.1 .
BT004178 mRNA. Translation: AAO42197.1 .
BT005462 mRNA. Translation: AAO63882.1 .
AY084703 mRNA. Translation: AAM61277.1 .
RefSeqi NP_001119181.1. NM_001125709.1. [Q84JD5-1 ]
NP_568174.1. NM_120758.3. [Q84JD5-1 ]
UniGenei At.32818.

3D structure databases

ProteinModelPortali Q84JD5.
SMRi Q84JD5. Positions 82-357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 15843. 1 interaction.
IntActi Q84JD5. 1 interaction.
MINTi MINT-8390464.

Proteomic databases

PaxDbi Q84JD5.
PRIDEi Q84JD5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G06750.1 ; AT5G06750.1 ; AT5G06750 . [Q84JD5-1 ]
AT5G06750.3 ; AT5G06750.3 ; AT5G06750 . [Q84JD5-1 ]
GeneIDi 830564.
KEGGi ath:AT5G06750.

Organism-specific databases

TAIRi AT5G06750.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000238703.
InParanoidi Q84JD5.
OMAi TVVVVYI.
PhylomeDBi Q84JD5.

Enzyme and pathway databases

BioCyci ARA:AT5G06750-MONOMER.
ARA:GQT-993-MONOMER.
ARA:GQT-994-MONOMER.

Gene expression databases

Genevestigatori Q84JD5.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. XI."
    Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H., Tabata S.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C68_ARATH
AccessioniPrimary (citable) accession number: Q84JD5
Secondary accession number(s): Q8LFQ7, Q9FG32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3