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Q84JD5

- P2C68_ARATH

UniProt

Q84JD5 - P2C68_ARATH

Protein

Probable protein phosphatase 2C 68

Gene

At5g06750

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Manganese 1By similarity
    Metal bindingi87 – 871Manganese 2By similarity
    Metal bindingi88 – 881Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi291 – 2911Manganese 2By similarity
    Metal bindingi350 – 3501Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G06750-MONOMER.
    ARA:GQT-993-MONOMER.
    ARA:GQT-994-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 68 (EC:3.1.3.16)
    Short name:
    AtPP2C68
    Gene namesi
    Ordered Locus Names:At5g06750
    ORF Names:MPH15.11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G06750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Probable protein phosphatase 2C 68PRO_0000367989Add
    BLAST

    Proteomic databases

    PaxDbiQ84JD5.
    PRIDEiQ84JD5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ84JD5.

    Interactioni

    Protein-protein interaction databases

    BioGridi15843. 1 interaction.
    IntActiQ84JD5. 1 interaction.
    MINTiMINT-8390464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ84JD5.
    SMRiQ84JD5. Positions 82-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 331250PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 3511Poly-AspAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000238703.
    InParanoidiQ84JD5.
    OMAiTVVVVYI.
    PhylomeDBiQ84JD5.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q84JD5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSWLARMAL FCLRPMRRYG RMNRDDDDDD DHDGDSSSSG DSLLWSRELE    50
    RHSFGDFSIA VVQANEVIED HSQVETGNGA VFVGVYDGHG GPEASRYISD 100
    HLFSHLMRVS RERSCISEEA LRAAFSATEE GFLTLVRRTC GLKPLIAAVG 150
    SCCLVGVIWK GTLLIANVGD SRAVLGSMGS NNNRSNKIVA EQLTSDHNAA 200
    LEEVRQELRS LHPDDSHIVV LKHGVWRIKG IIQVSRSIGD AYLKRPEFSL 250
    DPSFPRFHLA EELQRPVLSA EPCVYTRVLQ TSDKFVIFAS DGLWEQMTNQ 300
    QAVEIVNKHP RPGIARRLVR RAITIAAKKR EMNYDDLKKV ERGVRRFFHD 350
    DITVVVIFID NELLMVEKAT VPELSIKGFS HTVGPSKFSI FLS 393
    Length:393
    Mass (Da):44,140
    Last modified:June 1, 2003 - v1
    Checksum:iCAB959A38511D7B8
    GO

    Sequence cautioni

    The sequence BAB09809.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti268 – 2681L → S in AAM61277. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002032 Genomic DNA. Translation: BAB09809.1. Different initiation.
    CP002688 Genomic DNA. Translation: AED91058.1.
    CP002688 Genomic DNA. Translation: AED91060.1.
    BT004178 mRNA. Translation: AAO42197.1.
    BT005462 mRNA. Translation: AAO63882.1.
    AY084703 mRNA. Translation: AAM61277.1.
    RefSeqiNP_001119181.1. NM_001125709.1. [Q84JD5-1]
    NP_568174.1. NM_120758.3. [Q84JD5-1]
    UniGeneiAt.32818.

    Genome annotation databases

    EnsemblPlantsiAT5G06750.1; AT5G06750.1; AT5G06750. [Q84JD5-1]
    AT5G06750.3; AT5G06750.3; AT5G06750. [Q84JD5-1]
    GeneIDi830564.
    KEGGiath:AT5G06750.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002032 Genomic DNA. Translation: BAB09809.1 . Different initiation.
    CP002688 Genomic DNA. Translation: AED91058.1 .
    CP002688 Genomic DNA. Translation: AED91060.1 .
    BT004178 mRNA. Translation: AAO42197.1 .
    BT005462 mRNA. Translation: AAO63882.1 .
    AY084703 mRNA. Translation: AAM61277.1 .
    RefSeqi NP_001119181.1. NM_001125709.1. [Q84JD5-1 ]
    NP_568174.1. NM_120758.3. [Q84JD5-1 ]
    UniGenei At.32818.

    3D structure databases

    ProteinModelPortali Q84JD5.
    SMRi Q84JD5. Positions 82-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 15843. 1 interaction.
    IntActi Q84JD5. 1 interaction.
    MINTi MINT-8390464.

    Proteomic databases

    PaxDbi Q84JD5.
    PRIDEi Q84JD5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G06750.1 ; AT5G06750.1 ; AT5G06750 . [Q84JD5-1 ]
    AT5G06750.3 ; AT5G06750.3 ; AT5G06750 . [Q84JD5-1 ]
    GeneIDi 830564.
    KEGGi ath:AT5G06750.

    Organism-specific databases

    TAIRi AT5G06750.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000238703.
    InParanoidi Q84JD5.
    OMAi TVVVVYI.
    PhylomeDBi Q84JD5.

    Enzyme and pathway databases

    BioCyci ARA:AT5G06750-MONOMER.
    ARA:GQT-993-MONOMER.
    ARA:GQT-994-MONOMER.

    Gene expression databases

    Genevestigatori Q84JD5.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. XI."
      Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H., Tabata S.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C68_ARATH
    AccessioniPrimary (citable) accession number: Q84JD5
    Secondary accession number(s): Q8LFQ7, Q9FG32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3