Q84HF4 (KYNB_PSEFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Synonyms:	qbsH

Organism

Pseudomonas fluorescens

Taxonomic identifier

294 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Siderophore biosynthesis; quinolobactin biosynthesis. Ref.1 Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Ref.1
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Kynurenine formamidase		PRO_0000362132

Sequences

	Sequence		Length	Mass (Da)
	Q84HF4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0A59AF3DDEEA97ED	FASTA	218	23,629
	10 20 30 40 50 60 MPTRKLFDIS PPITTAIATW PGDTDYQQEP VWVLDHQCPV NVGKITLSAH TGAHADAPLH 70 80 90 100 110 120 YSNSGAAIGS VPLEPYLGTC RVIHCFDSDG LVRPAQLLPH LAQAPERILL RTYRHSDPCI 130 140 150 160 170 180 WDQHSTAIAV AAIELLARHG VKLVGIDTPS VDPQHSKTLD AHHAIQRHGM AILEGLVLDE 190 200 210 VPAGDYELIA LPLKFMALDA SPVRAVLRSL PTQVPRSG

References

[1]

"The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway." Matthijs S., Baysse C., Koedam N., Tehrani K.A., Verheyden L., Budzikiewicz H., Schaefer M., Hoorelbeke B., Meyer J.-M., De Greve H., Cornelis P. Mol. Microbiol. 52:371-384(2004) [PubMed: 15066027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PATHWAY. Strain: ATCC 17400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY271621 Genomic DNA. Translation: AAL65290.1.
3D structure databases
ProteinModelPortal	Q84HF4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_PSEFL

Accession

Primary (citable) accession number: Q84HF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2003
Last modified:	September 21, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program