ID   Q84HB8_STRCZ            Unreviewed;       385 AA.
AC   Q84HB8;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   28-JUN-2023, entry version 65.
DE   SubName: Full=Epoxide hydrolase {ECO:0000313|EMBL:AAM77995.1};
OS   Streptomyces carzinostaticus subsp. neocarzinostaticus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=167636 {ECO:0000313|EMBL:AAM77995.1};
RN   [1] {ECO:0000313|EMBL:AAM77995.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 15944 {ECO:0000313|EMBL:AAM77995.1};
RX   PubMed=15797213; DOI=10.1016/j.chembiol.2004.12.013;
RA   Liu W., Nonaka K., Nie L., Zhang J., Christenson S.D., Bae J.,
RA   Van Lanen S.G., Zazopoulos E., Farnet C.M., Yang C.F., Shen B.;
RT   "The neocarzinostatin biosynthetic gene cluster from Streptomyces
RT   carzinostaticus ATCC 15944 involving two iterative type I polyketide
RT   synthases.";
RL   Chem. Biol. 12:293-302(2005).
RN   [2] {ECO:0007829|PDB:4I19}
RP   X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS).
RA   Tan K., Bigelow L., Clancy S., Babnigg G., Bingman C.A., Yennamalli R.,
RA   Lohman J., Ma M., Shen B., Phillips Jr., G.N., Joachimiak A.;
RT   "The crystal structure of an epoxide hydrolase from Streptomyces
RT   carzinostaticus subsp. neocarzinostaticus.";
RL   Submitted (NOV-2012) to the PDB data bank.
RN   [3] {ECO:0007829|PDB:4QA9}
RP   X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS).
RA   Wang F., Tan K., Bigelow L., Clancy S., Babnigg G., Bingman C.A.,
RA   Yennamalli R., Lohman J., Ma M., Shen B., Joachimiak A., Phillips Jr.,
RA   G.N.;
RT   "Ensemble refinement of an epoxide hydrolase from Streptomyces
RT   carzinostaticus subsp. neocarzinostaticus.";
RL   Submitted (MAY-2014) to the PDB data bank.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family.
CC       {ECO:0000256|ARBA:ARBA00010088}.
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DR   EMBL; AY117439; AAM77995.1; -; Genomic_DNA.
DR   PDB; 4I19; X-ray; 2.15 A; A=1-385.
DR   PDB; 4QA9; X-ray; 1.56 A; A=1-385.
DR   PDBsum; 4I19; -.
DR   PDBsum; 4QA9; -.
DR   AlphaFoldDB; Q84HB8; -.
DR   SMR; Q84HB8; -.
DR   ESTHER; strcz-Q84HB8; Epoxide_hydrolase.
DR   KEGG; ag:AAM77995; -.
DR   GO; GO:0016803; F:ether hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   InterPro; IPR010497; Epoxide_hydro_N.
DR   InterPro; IPR016292; Epoxide_hydrolase.
DR   PANTHER; PTHR21661:SF35; EPOXIDE HYDROLASE; 1.
DR   PANTHER; PTHR21661; EPOXIDE HYDROLASE 1-RELATED; 1.
DR   Pfam; PF06441; EHN; 1.
DR   PIRSF; PIRSF001112; Epoxide_hydrolase; 1.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4I19, ECO:0007829|PDB:4QA9};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAM77995.1}.
FT   DOMAIN          1..105
FT                   /note="Epoxide hydrolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06441"
SQ   SEQUENCE   385 AA;  42907 MW;  41F31C25B54AAF74 CRC64;
     MRPFQVQIPQ ADIDDLKRRL SETRWPELVD VGWSRGAPLS YIKELAEYWR DGFDWRAAER
     RINQYPQFTT EIDGATIHFL HVRSPEPDAT PMVITHGWPG TPVEFLDIIG PLTDPRAHGG
     DPADAFHLVI PSLPGFGLSG PLKSAGWELG RIAMAWSKLM ASLGYERYIA QGGDIGAFTS
     LLLGAIDPSH LAGIHVNLLQ TNLSGEPGEL ETLSDADKAR LAVSERFLDD LSGPMKMQST
     RPHTIGYMLN DSPVAQLAYL LEMFKHWAQT ENVPEDAVDR DLMLTHISLF WFTATGGSAA
     QAHYELKPFL PITSLIGRSP TLDVPMGVAV YPGALFQPVR SLAERDFKQI VHWAELDRGG
     HFSAMEEPDL FVDDLRTFNR TLKKL
//