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Protein
Submitted name:

Subtilisin

Gene

aprE

Organism
Bacillus subtilis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BRENDAi3.4.21.62. 658.

Names & Taxonomyi

Protein namesi
Submitted name:
SubtilisinImported (EC:3.4.21.62Imported)
Gene namesi
Name:aprEImported
OrganismiBacillus subtilisImported
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Structurei

3D structure databases

ProteinModelPortaliQ84F18.
SMRiQ84F18. Positions 36-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR010259. S8pro/Inhibitor_I9.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF05922. Inhibitor_I9. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q84F18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSKKLWISL LFALTLIFTM AFSNMSAQAA GKSSTEKKYI VGFKQTMSAM
60 70 80 90 100
SSAKKKDVIS EKGGKVQKQF KYVNAAAATL DAKAVKELKQ DPSVAYVEED
110 120 130 140 150
HIAHQYAQSV PYGISQIKAP ALHSQGYTGS NVKVAVIDSG IDSSHPDLNV
160 170 180 190 200
RGGASFVPSE TNPYQDGSSH GTHVAGTVAA LNNSIGVLGV APNASLYAVK
210 220 230 240 250
VLDSTGNGQY SWIINGIEWA ISNKMDVINM SLGGPSGSTA LKSVVDRAVA
260 270 280 290 300
SGIVVVAAAG NEGTSGSSST IGYPAKYPST IAVGAVNSSN QRGSFSSVGP
310 320 330 340 350
ELDVMAPGVS IQSTLPGGTY GAYNGTSMAT PHVAGAAALI LSKHPTWTNA
360 370 380
QVRDRLESTT TYLGNSFYYG KGLINVQAAA Q
Length:381
Mass (Da):39,555
Last modified:June 1, 2003 - v1
Checksum:iCE1EDDEFC09B3560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ699519 Genomic DNA. Translation: ADY38664.1.
AJ539133 Genomic DNA. Translation: CAD62180.1.

Genome annotation databases

PATRICi37937476. VBIBacSub155824_3004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ699519 Genomic DNA. Translation: ADY38664.1.
AJ539133 Genomic DNA. Translation: CAD62180.1.

3D structure databases

ProteinModelPortaliQ84F18.
SMRiQ84F18. Positions 36-381.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICi37937476. VBIBacSub155824_3004.

Enzyme and pathway databases

BRENDAi3.4.21.62. 658.

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiIPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR010259. S8pro/Inhibitor_I9.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF05922. Inhibitor_I9. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Activation of subtilin precursors by Bacillus subtilis extracellular serine proteases subtilisin (AprE), WprA and Vpr."
    Corvey C.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 6633Imported.
  2. "Cloning of a fibrinolytic enzyme (subtilisin) gene from Bacillus subtilis in Escherichia coli."
    Ghasemi Y., Dabbagh F., Ghasemian A.
    Mol. Biotechnol. 52:1-7(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PTCC 1023Imported.

Entry informationi

Entry nameiQ84F18_BACIU
AccessioniPrimary (citable) accession number: Q84F18
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.