Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q84939 (NSP1_ROTPG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 1

Short name=NSP1
Alternative name(s):
NCVP2
Non-structural RNA-binding protein 53
Short name=NS53
OrganismRotavirus A (strain Pig/United States/Gottfried/1983 G4-P2B[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1) (RV-A)
Taxonomic identifier10917 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Seems to induce the proteasome-dependent degradation of IRF3, IRF5 and IRF7, thereby antagonizing the cellular interferon response and establishment of the antiviral state. Binds and targets IRF3 early post-infection and suppresses IRF3 nuclear translocation By similarity.

Subunit structure

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation By similarity.

Subcellular location

Host cytoplasmhost cytoskeleton By similarity.

Domain

The zinc-finger domain is important, but not sufficient for binding and degrading IRF3. It is sometimes described as a RING zinc-finger, but it is atypical and it is unclear whether it is related with ubiquitin ligase activity By similarity.

Sequence similarities

Belongs to the rotavirus A NSP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Non-structural protein 1
PRO_0000369092

Regions

Zinc finger42 – 7938 Potential
Region1 – 8181RNA-binding By similarity
Region82 – 17695Important for cytoskeleton localization By similarity
Region313 – 486174Interaction with IRF3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q84939 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F4BF96DD3BD584ED

FASTA48657,268
        10         20         30         40         50         60 
MATFKDACYY YKRLNKLNHA VLKLGVNDAW RPSPPTKYKG WCLDCCQHTD LTYCRGCSIY 

        70         80         90        100        110        120 
HVCQWCNQYG RCFLDDEPHL LRMRTFKNNV TKEDLANLID MYNVLFPVNQ KTVNKFINNT 

       130        140        150        160        170        180 
KQHKCRNEYV PQWYNHLLMP ITLQSLSIEL DGDTYYIFGY YDNMKNINQT PFSFVNLIDM 

       190        200        210        220        230        240 
YDKLLLDDVN FNRMSFLPLI LQQEYALRYF SKSRFISEEK RQINHSHFSI NILENLHNPN 

       250        260        270        280        290        300 
FKIQITRNCS TMSVRWNEAC KLVKDVGTYF DILKTSHVEF YDVSPRCRMF TQHKLKAVSK 

       310        320        330        340        350        360 
VIKPNYVTSN HRALATEVHN CRWCSVNNNL IVWNDFRLRN ICDNILNFIR ALIKSNTGIG 

       370        380        390        400        410        420 
HCSSQERIHI YIRDVFDVCD ESKWNASVVG IFNCLEPVEL GNAHYILLNH EVNWDVANVL 

       430        440        450        460        470        480 
IQNIGKIPQI LTLNDVITAL HSMIYDWFDV RYMRNTPTTT FTVDKLKQLC ARRKTVDYDS 


GVSDVE 

« Hide

References

[1]"Comparison of the rotavirus nonstructural protein NSP1 (NS53) from different species by sequence analysis and northern blot hybridization."
Dunn S.J., Cross T.L., Greenberg H.B.
Virology 203:178-183(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U08431 Genomic RNA. Translation: AAA50494.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002148. Rotavirus_NSP1.
[Graphical view]
PfamPF00981. Rota_NS53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP1_ROTPG
AccessionPrimary (citable) accession number: Q84939
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families