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Q848S6

- BLKPC_KLEOX

UniProt

Q848S6 - BLKPC_KLEOX

Protein

Carbapenem-hydrolyzing beta-lactamase KPC

Gene

bla

Organism
Klebsiella oxytoca
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Enzyme regulationi

    Not inhibited by EDTA, inhibited by clavulanic acid and tazobactam.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei69 – 691Acyl-ester intermediateBy similarity
    Active sitei167 – 1671Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbapenem-hydrolyzing beta-lactamase KPC (EC:3.5.2.6)
    Alternative name(s):
    Carbapenem-hydrolyzing beta-lactamase KPC-2
    Gene namesi
    Name:bla
    Synonyms:kpc, kpc2
    Encoded oniPlasmid conjugative 70kb0 Publication
    OrganismiKlebsiella oxytoca
    Taxonomic identifieri571 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 293269Carbapenem-hydrolyzing beta-lactamase KPCPRO_0000349144Add
    BLAST

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ848S6.
    SMRiQ848S6. Positions 30-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni233 – 2353Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q848S6-1 [UniParc]FASTAAdd to Basket

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    MSLYRRLVLL SCLSWPLAGF SATALTNLVA EPFAKLEQDF GGSIGVYAMD    50
    TGSGATVSYR AEERFPLCSS FKGFLAAAVL ARSQQQAGLL DTPIRYGKNA 100
    LVPWSPISEK YLTTGMTVAE LSAAAVQYSD NAAANLLLKE LGGPAGLTAF 150
    MRSIGDTTFR LDRWELELNS AIPGDARDTS SPRAVTESLQ KLTLGSALAA 200
    PQRQQFVDWL KGNTTGNHRI RAAVPADWAV GDKTGTCGVY GTANDYAVVW 250
    PTGRAPIVLA VYTRAPNKDD KHSEAVIAAA ARLALEGLGV NGQ 293
    Length:293
    Mass (Da):31,115
    Last modified:June 1, 2003 - v1
    Checksum:i13EB2FC28005EE5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY210886 Genomic DNA. Translation: AAO53443.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY210886 Genomic DNA. Translation: AAO53443.1 .

    3D structure databases

    ProteinModelPortali Q848S6.
    SMRi Q848S6. Positions 30-293.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q848S6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2."
      Yigit H., Queenan A.M., Rasheed J.K., Biddle J.W., Domenech-Sanchez A., Alberti S., Bush K., Tenover F.C.
      Antimicrob. Agents Chemother. 47:3881-3889(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBSTRATES, ENZYME REGULATION.
      Strain: 3127.

    Entry informationi

    Entry nameiBLKPC_KLEOX
    AccessioniPrimary (citable) accession number: Q848S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Initially two different KPC beta-lactamases were identified from two different bacteria (KPC-1 and KPC-2); they were later shown to be identical.

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3