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Q84850

- Q84850_HRSV

UniProt

Q84850 - Q84850_HRSV

Protein

Fusion glycoprotein F0

Gene
N/A
Organism
Human respiratory syncytial virus
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: UniProtKB-KW
    2. induction by virus of host cell-cell fusion Source: InterPro

    Keywords - Biological processi

    Fusion of virus membrane with host cell membraneSAAS annotation, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fusion glycoprotein F0UniRule annotation
    OrganismiHuman respiratory syncytial virusImported
    Taxonomic identifieri11250 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaePneumovirinaePneumovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020 PotentialImportedAdd
    BLAST
    Chaini21 – 574554 PotentialImportedPRO_5000145466Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Subunit structurei

    Homotrimer of disulfide-linked F1-F2.UniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RRRX-ray2.82A/C/E/G/I/M26-109[»]
    ProteinModelPortaliQ84850.
    SMRiQ84850. Positions 158-207, 477-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the paramyxoviruses fusion glycoprotein family.UniRule annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    InterProiIPR000776. Fusion_F0_Paramyxovir.
    [Graphical view]
    PfamiPF00523. Fusion_gly. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q84850-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELLILKANA ITTILTAVTF CFASGQNITE EFYQSTCSAV SKGYLSALRT    50
    GWYTSVITIE LSNIKENKCN GTDAKVKLIK QELDKYKNAV TELQLLMQST 100
    PATNNRARRE LPRFMNYTLN NAKKTNVTLS KKRKRRFLGF LLGVGSAIAS 150
    GVAVSKVLHL EGEVNKIKSA LLSTNKAVVS LSNGVSVLTS KVLDLKNYID 200
    KQLLPIVNKQ SCSISNIETV IEFQQKNNRL LEITREFSVN AGVTTPVSTY 250
    MLTNSELLSL INDMPITNDQ KKLMSNNVQI VRQQSYSIMS IIKEEVLAYV 300
    VQLPLYGVID TPCWKLHTSP LCTTNTKEGS NICLTRTDRG WFCDNAGSVS 350
    FFPQAETCKV QSNRVFCDTM NSLTLPSEVN LCNVDIFNPK YDCKIMTSKT 400
    DVSSSVITSL GAIVSCYGKT KCTASNKNRG IIKTFSNGCD YVSNKGVDTV 450
    SVGNTLYYVN KQEGKSLYVK GEPIINFYDP LVFPSDEFDA SISQVNEKIN 500
    QSLAFIRKSD ELLHNVNAGK STTNIMITTI IIVIIVILLS LIAVGLLLYC 550
    KARSTPVTLS KDQLSGINNI AFSN 574
    Length:574
    Mass (Da):63,365
    Last modified:November 1, 1996 - v1
    Checksum:i7777F459F0FBC7C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02221 mRNA. Translation: CAA26143.1.
    PIRiB28929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02221 mRNA. Translation: CAA26143.1 .
    PIRi B28929.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3RRR X-ray 2.82 A/C/E/G/I/M 26-109 [» ]
    ProteinModelPortali Q84850.
    SMRi Q84850. Positions 158-207, 477-516.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000776. Fusion_F0_Paramyxovir.
    [Graphical view ]
    Pfami PF00523. Fusion_gly. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Respiratory syncytial virus fusion glycoprotein: nucleotide sequence of mRNA, identification of cleavage activation site and amino acid sequence of N-terminus of F1 subunit."
      Elango N., Satake M., Coligan J.E., Norrby E., Camargo E., Venkatesan S.
      Nucleic Acids Res. 13:1559-1574(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes."
      McLellan J.S., Yang Y., Graham B.S., Kwong P.D.
      J. Virol. 85:7788-7796(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF 26-109, GLYCOSYLATION AT ASN-70.

    Entry informationi

    Entry nameiQ84850_HRSV
    AccessioniPrimary (citable) accession number: Q84850
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3