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Q84850

- Q84850_HRSV

UniProt

Q84850 - Q84850_HRSV

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Protein

Fusion glycoprotein F0

Gene
N/A
Organism
Human respiratory syncytial virus
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: UniProtKB-KW
  2. induction by virus of host cell-cell fusion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membraneSAAS annotation, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Fusion glycoprotein F0UniRule annotation
OrganismiHuman respiratory syncytial virusImported
Taxonomic identifieri11250 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaePneumovirinaePneumovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 PotentialImportedAdd
BLAST
Chaini21 – 574554 PotentialImportedPRO_5000145466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotrimer of disulfide-linked F1-F2.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RRRX-ray2.82A/C/E/G/I/M26-109[»]
ProteinModelPortaliQ84850.
SMRiQ84850. Positions 158-207, 477-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paramyxoviruses fusion glycoprotein family.UniRule annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

InterProiIPR000776. Fusion_F0_Paramyxovir.
[Graphical view]
PfamiPF00523. Fusion_gly. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q84850-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLILKANA ITTILTAVTF CFASGQNITE EFYQSTCSAV SKGYLSALRT
60 70 80 90 100
GWYTSVITIE LSNIKENKCN GTDAKVKLIK QELDKYKNAV TELQLLMQST
110 120 130 140 150
PATNNRARRE LPRFMNYTLN NAKKTNVTLS KKRKRRFLGF LLGVGSAIAS
160 170 180 190 200
GVAVSKVLHL EGEVNKIKSA LLSTNKAVVS LSNGVSVLTS KVLDLKNYID
210 220 230 240 250
KQLLPIVNKQ SCSISNIETV IEFQQKNNRL LEITREFSVN AGVTTPVSTY
260 270 280 290 300
MLTNSELLSL INDMPITNDQ KKLMSNNVQI VRQQSYSIMS IIKEEVLAYV
310 320 330 340 350
VQLPLYGVID TPCWKLHTSP LCTTNTKEGS NICLTRTDRG WFCDNAGSVS
360 370 380 390 400
FFPQAETCKV QSNRVFCDTM NSLTLPSEVN LCNVDIFNPK YDCKIMTSKT
410 420 430 440 450
DVSSSVITSL GAIVSCYGKT KCTASNKNRG IIKTFSNGCD YVSNKGVDTV
460 470 480 490 500
SVGNTLYYVN KQEGKSLYVK GEPIINFYDP LVFPSDEFDA SISQVNEKIN
510 520 530 540 550
QSLAFIRKSD ELLHNVNAGK STTNIMITTI IIVIIVILLS LIAVGLLLYC
560 570
KARSTPVTLS KDQLSGINNI AFSN
Length:574
Mass (Da):63,365
Last modified:November 1, 1996 - v1
Checksum:i7777F459F0FBC7C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02221 mRNA. Translation: CAA26143.1.
PIRiB28929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02221 mRNA. Translation: CAA26143.1 .
PIRi B28929.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RRR X-ray 2.82 A/C/E/G/I/M 26-109 [» ]
ProteinModelPortali Q84850.
SMRi Q84850. Positions 158-207, 477-516.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000776. Fusion_F0_Paramyxovir.
[Graphical view ]
Pfami PF00523. Fusion_gly. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Respiratory syncytial virus fusion glycoprotein: nucleotide sequence of mRNA, identification of cleavage activation site and amino acid sequence of N-terminus of F1 subunit."
    Elango N., Satake M., Coligan J.E., Norrby E., Camargo E., Venkatesan S.
    Nucleic Acids Res. 13:1559-1574(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes."
    McLellan J.S., Yang Y., Graham B.S., Kwong P.D.
    J. Virol. 85:7788-7796(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF 26-109, GLYCOSYLATION AT ASN-70.

Entry informationi

Entry nameiQ84850_HRSV
AccessioniPrimary (citable) accession number: Q84850
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3