Q846B4 (ARGC_BACAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:

argC

Organism

Bacillus amyloliquefaciens (Bacillus velezensis)

Taxonomic identifier

1390 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112378
Sites
	Active site	147	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q846B4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 0A70851145378DA8	FASTA	344	37,925
	10 20 30 40 50 60 MKIGFVGATG YGGTELVRIL SHHPHAEECI LYQTSGEGNV YSEGYPHLTG LADLKPIDMN 70 80 90 100 110 120 TIKHEIDIMF LAAPPGVSSE LTPKLADAWV TVIDLSGDLR IKEPAEYEKW YKRTAAPKAV 130 140 150 160 170 180 IQEAVYGLAE LNQLAIQQAK LIANPGCFPT AVLLGLAPLA KKKLLDESFV IVDAKTGVSG 190 200 210 220 230 240 AGRKASMGTH FSELNDNFKI YKVNEHQHTP EIEQALNEWQ PGLGPITFSA HLVPMTRGIM 250 260 270 280 290 300 ATMYTRLTCD LTADDLHDLY SEFYQDSYFV RVRPKGQYPQ TKEVYGSNFC DIGVTLDERT 310 320 330 340 NRVTIVSVID NLMKGAAGQA VQNFNLMNGW DEETGLTIIT PIYA

References

[1]	"argC gene of Bacillus amyloliquefaciens." Min K.-H. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY248750 Genomic DNA. Translation: AAO72303.1.
3D structure databases
ProteinModelPortal	Q846B4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACAM

Accession

Primary (citable) accession number: Q846B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	June 1, 2003
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program