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Q845V3

- HISX_BURM1

UniProt

Q845V3 - HISX_BURM1

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Protein
Histidinol dehydrogenase
Gene
hisD, Bmul_0328, BMULJ_02926
Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381NAD By similarity
Binding sitei199 – 1991NAD By similarity
Binding sitei222 – 2221NAD By similarity
Binding sitei245 – 2451Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Metal bindingi270 – 2701Zinc By similarity
Binding sitei270 – 2701Substrate By similarity
Active sitei335 – 3351Proton acceptor By similarity
Active sitei336 – 3361Proton acceptor By similarity
Binding sitei336 – 3361Substrate By similarity
Metal bindingi369 – 3691Zinc By similarity
Binding sitei369 – 3691Substrate By similarity
Binding sitei423 – 4231Substrate By similarity
Metal bindingi428 – 4281Zinc By similarity
Binding sitei428 – 4281Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBMUL395019:GIYO-2924-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Bmul_0328, BMULJ_02926
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000007064: Chromosome 1, UP000008815: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Histidinol dehydrogenaseUniRule annotation
PRO_0000135749Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi395019.Bmul_0328.

Structurei

3D structure databases

ProteinModelPortaliQ845V3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q845V3-1 [UniParc]FASTAAdd to Basket

« Hide

MSITIRKLDS TSEGFDAALR AVLAFEASED EAIERSVAQI LADVKSRGDA    50
AVLEYTNRFD RLNADSVAAL ELPQDALQAA LDGLEPKARA ALEAAAARVR 100
GYHEKQKIEC GTHSWQYTES DGTVLGQKIT PLDRVGLYVP GGKAAYPSSV 150
LMNAIPARVA GVGEIVMVVP TPDGVKNDLV LAAALLGGVD RVFTIGGAQA 200
VGALAYGTAT VPAVDKICGP GNAYVASAKR RVFGTVGIDM IAGPSEILVL 250
CDGTTDPSWV AMDLFSQAEH DELAQSILLC PDASFIERVE KAIAELLPSM 300
PRQDVIRASL EGRGALIKVR DMTEACRIAN DIAPEHLEIS ALEPQQWSQQ 350
IRHAGAIFLG RYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFIKRSS 400
LIEVSAEGAH TLGEIAAELA YGEGLQAHAK SAEFRMKG 438
Length:438
Mass (Da):46,515
Last modified:September 2, 2008 - v2
Checksum:i8F702C8C7E014B1D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 10112AALEA…ARVRG → GRAGSGCRTRAR in BAC65270. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB091436 Genomic DNA. Translation: BAC65270.1.
CP000868 Genomic DNA. Translation: ABX14023.1.
AP009385 Genomic DNA. Translation: BAG44811.1.
RefSeqiYP_001578520.1. NC_010084.1.
YP_001947347.1. NC_010804.1.

Genome annotation databases

EnsemblBacteriaiABX14023; ABX14023; Bmul_0328.
BAG44811; BAG44811; BMULJ_02926.
GeneIDi5765433.
6359505.
KEGGibmj:BMULJ_02926.
bmu:Bmul_0328.
PATRICi19167814. VBIBurMul203716_3956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB091436 Genomic DNA. Translation: BAC65270.1 .
CP000868 Genomic DNA. Translation: ABX14023.1 .
AP009385 Genomic DNA. Translation: BAG44811.1 .
RefSeqi YP_001578520.1. NC_010084.1.
YP_001947347.1. NC_010804.1.

3D structure databases

ProteinModelPortali Q845V3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395019.Bmul_0328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX14023 ; ABX14023 ; Bmul_0328 .
BAG44811 ; BAG44811 ; BMULJ_02926 .
GeneIDi 5765433.
6359505.
KEGGi bmj:BMULJ_02926.
bmu:Bmul_0328.
PATRICi 19167814. VBIBurMul203716_3956.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BMUL395019:GIYO-2924-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distribution and organization of auxotrophic genes on the multichromosomal genome of Burkholderia multivorans ATCC 17616."
    Komatsu H., Imura Y., Ohori A., Nagata Y., Tsuda M.
    J. Bacteriol. 185:3333-3343(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Burkholderia multivorans ATCC 17616."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J., Richardson P.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17616 / 249.
  3. "Complete genome sequence of Burkholderia multivorans ATCC 17616."
    Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N., Hattori M., Tsuda M.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17616 / 249.

Entry informationi

Entry nameiHISX_BURM1
AccessioniPrimary (citable) accession number: Q845V3
Secondary accession number(s): A9AE01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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