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Q83XM3 (G6PI_LACFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Synonyms:fruI
OrganismLactobacillus fermentum
Taxonomic identifier1613 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180657

Sites

Active site2901Proton donor By similarity
Active site3111 By similarity
Active site4251 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83XM3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B27B48837095A5F7

FASTA45049,417
        10         20         30         40         50         60 
METLSFDSSA LKKFVHPNEL GEMQAMVTAA DSELRNGTGA GADFRDWLHL PTDYDKDEFA 

        70         80         90        100        110        120 
RIEAAAKKIQ ADSEVLVVIG IGGSYLGARM AVDFLHHSFY QAQTAADRKQ PLVLFAGNSL 

       130        140        150        160        170        180 
SSSYIADLID VIGDRDFSVN VISKSGTTTE PSIAFRVFRQ LLEDKYGVDG ANARIYATTD 

       190        200        210        220        230        240 
RQRGALKTEA DAEGWGTFVI PDGVGGRFSV LTAVGLLPIA VSGADIDQLM AGAAKAEATY 

       250        260        270        280        290        300 
VNPDLTQNEA YQYAAYRNIL YRKGYTTELL ENYEPNMTML AEWWKQLAGE SEGKDQKGIY 

       310        320        330        340        350        360 
PSSANFTTDL HSLGQYIQEG RRNLMETVVK LAEPNHNVKV PSAKSDFDGL KYLEGKEIDW 

       370        380        390        400        410        420 
VNTQAYRAVV AAHTTGGVPV MTVNIAKEDE FTLGYLIYFF EVAIAISGYL NGINPFNQPG 

       430        440        450 
VEAYKTNMFG LLGKPGFEEI GEQLKKEMDD 

« Hide

References

[1]"Metabolic engineering of lactic acid bacteria for production of fermentation metabolites."
Helanto M.E.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NRRL B-1932.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ560768 Genomic DNA. Translation: CAD90946.1.

3D structure databases

ProteinModelPortalQ83XM3.
SMRQ83XM3. Positions 3-447.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-13041.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_LACFE
AccessionPrimary (citable) accession number: Q83XM3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways