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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactobacillus fermentum
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901Proton donorUniRule annotation
Active sitei311 – 3111UniRule annotation
Active sitei425 – 4251UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13041.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Synonyms:fruI
OrganismiLactobacillus fermentum
Taxonomic identifieri1613 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Glucose-6-phosphate isomerasePRO_0000180657Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ83XM3.
SMRiQ83XM3. Positions 3-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83XM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLSFDSSA LKKFVHPNEL GEMQAMVTAA DSELRNGTGA GADFRDWLHL
60 70 80 90 100
PTDYDKDEFA RIEAAAKKIQ ADSEVLVVIG IGGSYLGARM AVDFLHHSFY
110 120 130 140 150
QAQTAADRKQ PLVLFAGNSL SSSYIADLID VIGDRDFSVN VISKSGTTTE
160 170 180 190 200
PSIAFRVFRQ LLEDKYGVDG ANARIYATTD RQRGALKTEA DAEGWGTFVI
210 220 230 240 250
PDGVGGRFSV LTAVGLLPIA VSGADIDQLM AGAAKAEATY VNPDLTQNEA
260 270 280 290 300
YQYAAYRNIL YRKGYTTELL ENYEPNMTML AEWWKQLAGE SEGKDQKGIY
310 320 330 340 350
PSSANFTTDL HSLGQYIQEG RRNLMETVVK LAEPNHNVKV PSAKSDFDGL
360 370 380 390 400
KYLEGKEIDW VNTQAYRAVV AAHTTGGVPV MTVNIAKEDE FTLGYLIYFF
410 420 430 440 450
EVAIAISGYL NGINPFNQPG VEAYKTNMFG LLGKPGFEEI GEQLKKEMDD
Length:450
Mass (Da):49,417
Last modified:June 1, 2003 - v1
Checksum:iB27B48837095A5F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560768 Genomic DNA. Translation: CAD90946.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560768 Genomic DNA. Translation: CAD90946.1.

3D structure databases

ProteinModelPortaliQ83XM3.
SMRiQ83XM3. Positions 3-447.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciMetaCyc:MONOMER-13041.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Metabolic engineering of lactic acid bacteria for production of fermentation metabolites."
    Helanto M.E.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NRRL B-1932.

Entry informationi

Entry nameiG6PI_LACFE
AccessioniPrimary (citable) accession number: Q83XM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.