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Q83VZ4 (ACDH1_COMTE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 1

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene names
Name:tesF
OrganismComamonas testosteroni (Pseudomonas testosteroni)
Taxonomic identifier285 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657
PRO_0000387650

Regions

Nucleotide binding163 – 1719NAD By similarity

Sites

Active site1321Acyl-thioester intermediate By similarity
Binding site2741NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83VZ4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: F19FDF0742DB27B1

FASTA30732,667
        10         20         30         40         50         60 
MTQKKIKCAL IGPGNIGTDL LMKLQRSPIL EPVWMVGIDP ESDGLKRARE MGIKTTADGV 

        70         80         90        100        110        120 
DGLLPFVKED GIQIAFDATS AYVHAENSRK LNELGVLMID LTPAAIGPYC VPSVNLAEKV 

       130        140        150        160        170        180 
AEKAMNVNMV TCGGQATIPM VAAVSRVQAV SYGEIVATVS SRSVGPGTRK NIDEFTRTTS 

       190        200        210        220        230        240 
GAVEKIGGAQ KGKAIIVINP AEPPLIMRDT IHCLTVDTPK PAEIEASVHA MIKEVQKYVP 

       250        260        270        280        290        300 
GYKLVNGPVI DGNRVSIYME VEGLGDYLPK YAGNLDIMTA AAARTAEMFA EEILAGRFEL 


AEAAVAV 

« Hide

References

[1]"Gene encoding the hydrolase for the product of the meta-cleavage reaction in testosterone degradation by Comamonas testosteroni."
Horinouchi M., Hayashi T., Koshino H., Yamamoto T., Kudo T.
Appl. Environ. Microbiol. 69:2139-2152(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: TA441.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB063482 Genomic DNA. Translation: BAC67695.1.

3D structure databases

ProteinModelPortalQ83VZ4.
SMRQ83VZ4. Positions 1-295.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-16930.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH1_COMTE
AccessionPrimary (citable) accession number: Q83VZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families