Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:SF0046, S0048
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001980111 – 280Bis(5'-nucleosyl)-tetraphosphatase, symmetricalAdd BLAST280

Proteomic databases

PaxDbiQ83SQ2.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF0046.

Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Helixi13 – 22Combined sources10
Turni27 – 29Combined sources3
Beta strandi31 – 34Combined sources4
Beta strandi39 – 43Combined sources5
Helixi45 – 54Combined sources10
Helixi55 – 58Combined sources4
Beta strandi59 – 61Combined sources3
Helixi65 – 74Combined sources10
Helixi82 – 84Combined sources3
Helixi87 – 90Combined sources4
Helixi95 – 103Combined sources9
Beta strandi107 – 111Combined sources5
Turni112 – 115Combined sources4
Beta strandi116 – 121Combined sources6
Helixi129 – 144Combined sources16
Helixi148 – 154Combined sources7
Helixi169 – 181Combined sources13
Beta strandi185 – 187Combined sources3
Beta strandi190 – 195Combined sources6
Helixi200 – 202Combined sources3
Helixi210 – 212Combined sources3
Turni216 – 220Combined sources5
Beta strandi221 – 225Combined sources5
Helixi229 – 231Combined sources3
Beta strandi240 – 242Combined sources3
Turni247 – 250Combined sources4
Beta strandi251 – 257Combined sources7
Turni258 – 261Combined sources4
Beta strandi262 – 267Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DFJX-ray2.72A/B1-280[»]
ProteinModelPortaliQ83SQ2.
SMRiQ83SQ2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ83SQ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.

Family and domain databases

CDDicd07422. MPP_ApaH. 1 hit.
Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83SQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR
60 70 80 90 100
YVKSLGDSVR LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN
110 120 130 140 150
WLRRQPLLQI DEEKKLVMAH AGITPQWDLQ TAKECARDVE AVLSSDSYPF
160 170 180 190 200
FLDAMYGDMP NNWSPELRGL GRLRFITNAF TRMRFCFPNG QLDMYSKESP
210 220 230 240 250
EEAPAPLKPW FAIPGPVAEE YSIAFGHWAS LEGKGTPEGI YALDTGCCWG
260 270 280
GSLTCLRWED KQYFVQPSNR HKDLGEAAAS
Length:280
Mass (Da):31,283
Last modified:June 1, 2003 - v1
Checksum:iBD6560C73336B6BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41712.1.
AE014073 Genomic DNA. Translation: AAP15592.1.
RefSeqiNP_706005.1. NC_004337.2.
WP_000257186.1. NZ_LVJC01000008.1.

Genome annotation databases

EnsemblBacteriaiAAN41712; AAN41712; SF0046.
AAP15592; AAP15592; S0048.
GeneIDi1024575.
KEGGisfl:SF0046.
sft:NCTC1_00046.
sfx:S0048.
PATRICi18701026. VBIShiFle31049_0055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41712.1.
AE014073 Genomic DNA. Translation: AAP15592.1.
RefSeqiNP_706005.1. NC_004337.2.
WP_000257186.1. NZ_LVJC01000008.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DFJX-ray2.72A/B1-280[»]
ProteinModelPortaliQ83SQ2.
SMRiQ83SQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF0046.

Proteomic databases

PaxDbiQ83SQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN41712; AAN41712; SF0046.
AAP15592; AAP15592; S0048.
GeneIDi1024575.
KEGGisfl:SF0046.
sft:NCTC1_00046.
sfx:S0048.
PATRICi18701026. VBIShiFle31049_0055.

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.

Miscellaneous databases

EvolutionaryTraceiQ83SQ2.

Family and domain databases

CDDicd07422. MPP_ApaH. 1 hit.
Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPAH_SHIFL
AccessioniPrimary (citable) accession number: Q83SQ2
Secondary accession number(s): Q7C3B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.