Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:SF0046, S0048
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_0000198011Add
BLAST

Proteomic databases

PaxDbiQ83SQ2.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF0046.

Structurei

Secondary structure

1
280
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Helixi13 – 2210Combined sources
Turni27 – 293Combined sources
Beta strandi31 – 344Combined sources
Beta strandi39 – 435Combined sources
Helixi45 – 5410Combined sources
Helixi55 – 584Combined sources
Beta strandi59 – 613Combined sources
Helixi65 – 7410Combined sources
Helixi82 – 843Combined sources
Helixi87 – 904Combined sources
Helixi95 – 1039Combined sources
Beta strandi107 – 1115Combined sources
Turni112 – 1154Combined sources
Beta strandi116 – 1216Combined sources
Helixi129 – 14416Combined sources
Helixi148 – 1547Combined sources
Helixi169 – 18113Combined sources
Beta strandi185 – 1873Combined sources
Beta strandi190 – 1956Combined sources
Helixi200 – 2023Combined sources
Helixi210 – 2123Combined sources
Turni216 – 2205Combined sources
Beta strandi221 – 2255Combined sources
Helixi229 – 2313Combined sources
Beta strandi240 – 2423Combined sources
Turni247 – 2504Combined sources
Beta strandi251 – 2577Combined sources
Turni258 – 2614Combined sources
Beta strandi262 – 2676Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DFJX-ray2.72A/B1-280[»]
ProteinModelPortaliQ83SQ2.
SMRiQ83SQ2. Positions 2-268.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ83SQ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83SQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLIGDVH GCYDELIALL HKVEFTPGKD TLWLTGDLVA RGPGSLDVLR
60 70 80 90 100
YVKSLGDSVR LVLGNHDLHL LAVFAGISRN KPKDRLTPLL EAPDADELLN
110 120 130 140 150
WLRRQPLLQI DEEKKLVMAH AGITPQWDLQ TAKECARDVE AVLSSDSYPF
160 170 180 190 200
FLDAMYGDMP NNWSPELRGL GRLRFITNAF TRMRFCFPNG QLDMYSKESP
210 220 230 240 250
EEAPAPLKPW FAIPGPVAEE YSIAFGHWAS LEGKGTPEGI YALDTGCCWG
260 270 280
GSLTCLRWED KQYFVQPSNR HKDLGEAAAS
Length:280
Mass (Da):31,283
Last modified:June 1, 2003 - v1
Checksum:iBD6560C73336B6BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41712.1.
AE014073 Genomic DNA. Translation: AAP15592.1.
RefSeqiNP_706005.1. NC_004337.2.
WP_000257186.1. NZ_LM651928.1.

Genome annotation databases

EnsemblBacteriaiAAN41712; AAN41712; SF0046.
AAP15592; AAP15592; S0048.
GeneIDi1024575.
KEGGisfl:SF0046.
sft:NCTC1_00046.
sfx:S0048.
PATRICi18701026. VBIShiFle31049_0055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41712.1.
AE014073 Genomic DNA. Translation: AAP15592.1.
RefSeqiNP_706005.1. NC_004337.2.
WP_000257186.1. NZ_LM651928.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DFJX-ray2.72A/B1-280[»]
ProteinModelPortaliQ83SQ2.
SMRiQ83SQ2. Positions 2-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF0046.

Proteomic databases

PaxDbiQ83SQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN41712; AAN41712; SF0046.
AAP15592; AAP15592; S0048.
GeneIDi1024575.
KEGGisfl:SF0046.
sft:NCTC1_00046.
sfx:S0048.
PATRICi18701026. VBIShiFle31049_0055.

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiEOG66B3WP.

Miscellaneous databases

EvolutionaryTraceiQ83SQ2.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiAPAH_SHIFL
AccessioniPrimary (citable) accession number: Q83SQ2
Secondary accession number(s): Q7C3B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.