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Protein

Putative acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.By similarity

Catalytic activityi

Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].

GO - Molecular functioni

  1. [acyl-carrier-protein] phosphodiesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Putative acyl carrier protein phosphodiesterase (EC:3.1.4.14)
Short name:
ACP phosphodiesterase
Gene namesi
Name:acpH
Ordered Locus Names:SF0341, S0349
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002673 Componenti: Chromosome UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Putative acyl carrier protein phosphodiesterasePRO_0000226276Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198214.SF0341.

Family & Domainsi

Sequence similaritiesi

Belongs to the AcpH family.Curated

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
OMAiTEIRANQ.
OrthoDBiEOG6K6V7H.

Family and domain databases

InterProiIPR007431. ACP_phosphodiesterase.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83SG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNLPEVRE AQEWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE
60 70 80 90 100
FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA
110 120 130 140
SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASH KAL
Length:143
Mass (Da):17,418
Last modified:May 31, 2003 - v1
Checksum:iA0731A290EB3F83D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41999.1.
AE014073 Genomic DNA. No translation available.

Genome annotation databases

EnsemblBacteriaiAAN41999; AAN41999; SF0341.
PATRICi18712285. VBIShiFle86970_0391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41999.1.
AE014073 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF0341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN41999; AAN41999; SF0341.
PATRICi18712285. VBIShiFle86970_0391.

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
OMAiTEIRANQ.
OrthoDBiEOG6K6V7H.

Family and domain databases

InterProiIPR007431. ACP_phosphodiesterase.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiACPH_SHIFL
AccessioniPrimary (citable) accession number: Q83SG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2006
Last sequence update: May 31, 2003
Last modified: January 6, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. The N-terminus is shorter than in related proteins.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.