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Q83RR9

- NAGK_SHIFL

UniProt

Q83RR9 - NAGK_SHIFL

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi179 – 1791ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:SF1123, S1203
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303N-acetyl-D-glucosamine kinasePRO_0000270117Add
    BLAST

    Proteomic databases

    PaxDbiQ83RR9.

    Interactioni

    Protein-protein interaction databases

    STRINGi198214.SF1123.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83RR9.
    SMRiQ83RR9. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00884.
    OMAiPEIVAQW.
    OrthoDBiEOG61P6P0.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83RR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDIGGT KIALGVFDSG RQLQWEKRVP TPRDSYDAFL DAVCELVAEA    50
    DQRFGCKGSV GIGIPGMPET EDGKLYAANV PAASGKPLRA DLSARLDRDV 100
    RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVF NGKPITGKSY 150
    ITGEFGHMRL PVDALTMMGL DFPLRRCGCG QHGCIENYLS GRGFAWLYQH 200
    YYHQPLQAPE IIALYDQGDE QARAHVERYL DLLAVSLGNI LTIVDPDLVV 250
    IGGGLSNFPA ITTQLADRLP CHLLPVARVP RIERARHGDA GGMRGAAFLH 300
    LTD 303
    Length:303
    Mass (Da):32,987
    Last modified:June 1, 2003 - v1
    Checksum:i65572B2CCFEBFBA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN42741.1.
    AE014073 Genomic DNA. Translation: AAP16630.1.
    RefSeqiNP_707034.1. NC_004337.2.
    NP_836823.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN42741; AAN42741; SF1123.
    AAP16630; AAP16630; S1203.
    GeneIDi1024059.
    1076442.
    KEGGisfl:SF1123.
    sfx:S1203.
    PATRICi18703616. VBIShiFle31049_1313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN42741.1 .
    AE014073 Genomic DNA. Translation: AAP16630.1 .
    RefSeqi NP_707034.1. NC_004337.2.
    NP_836823.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali Q83RR9.
    SMRi Q83RR9. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF1123.

    Proteomic databases

    PaxDbi Q83RR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN42741 ; AAN42741 ; SF1123 .
    AAP16630 ; AAP16630 ; S1203 .
    GeneIDi 1024059.
    1076442.
    KEGGi sfl:SF1123.
    sfx:S1203.
    PATRICi 18703616. VBIShiFle31049_1313.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00884.
    OMAi PEIVAQW.
    OrthoDBi EOG61P6P0.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiNAGK_SHIFL
    AccessioniPrimary (citable) accession number: Q83RR9
    Secondary accession number(s): Q7C210
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3