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Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 29NADBy similarityAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductase (EC:1.1.1.58)
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene namesi
Name:uxaB
Ordered Locus Names:SF1572, S1699
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001707451 – 483Altronate oxidoreductaseAdd BLAST483

Proteomic databases

PaxDbiQ83RE1.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF1572.

Structurei

3D structure databases

ProteinModelPortaliQ83RE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QZW. Bacteria.
COG0246. LUCA.
HOGENOMiHOG000029586.
KOiK00041.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023668. Altronate_OxRdtase.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83RE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV
60 70 80 90 100
VRPIETSFPP SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS
110 120 130 140 150
EYDEFLKLAH NPEMRFVFSN TTEAGISYHA GDKFDDAPAV SYPAKLTRLL
160 170 180 190 200
FERFSHFNGA LDKGWIIIPC ELIDYNGDAL RELVLRYAQE WALPEAFIQW
210 220 230 240 250
LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDDFLDT AEHFYLFVIQ
260 270 280 290 300
GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG
310 320 330 340 350
LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP
360 370 380 390 400
YIKHQLLSIA LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY
410 420 430 440 450
RGERNGETYP VQDDAHWLER YQQLWSQHRD RVIGTQELVA IVLAEKDHWE
460 470 480
QDLTQVPGLV EQVANDLDAI LEKGMREAVR PLC
Length:483
Mass (Da):54,866
Last modified:June 1, 2003 - v1
Checksum:i60A4677D235BC2E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236D → G in AAP17054 (PubMed:12704152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43160.1.
AE014073 Genomic DNA. Translation: AAP17054.1.
RefSeqiNP_707453.1. NC_004337.2.

Genome annotation databases

EnsemblBacteriaiAAN43160; AAN43160; SF1572.
AAP17054; AAP17054; S1699.
GeneIDi1024755.
KEGGisfl:SF1572.
sfx:S1699.
PATRICi18704768. VBIShiFle31049_1884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43160.1.
AE014073 Genomic DNA. Translation: AAP17054.1.
RefSeqiNP_707453.1. NC_004337.2.

3D structure databases

ProteinModelPortaliQ83RE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF1572.

Proteomic databases

PaxDbiQ83RE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN43160; AAN43160; SF1572.
AAP17054; AAP17054; S1699.
GeneIDi1024755.
KEGGisfl:SF1572.
sfx:S1699.
PATRICi18704768. VBIShiFle31049_1884.

Phylogenomic databases

eggNOGiENOG4107QZW. Bacteria.
COG0246. LUCA.
HOGENOMiHOG000029586.
KOiK00041.

Enzyme and pathway databases

UniPathwayiUPA00246.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023668. Altronate_OxRdtase.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXAB_SHIFL
AccessioniPrimary (citable) accession number: Q83RE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.