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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene

pgsA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein catalyzes the committed step to the synthesis of the acidic phospholipids.UniRule annotation

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.UniRule annotation

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgsA)
  2. Phosphatidylglycerophosphatase A (pgpA), Phosphatidylglycerophosphatase C (pgpC), Phosphatidylglycerophosphatase B (pgpB)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseUniRule annotation (EC:2.7.8.5UniRule annotation)
Alternative name(s):
Phosphatidylglycerophosphate synthaseUniRule annotation
Short name:
PGP synthaseUniRule annotation
Gene namesi
Name:pgsAUniRule annotation
Ordered Locus Names:SF1955, S2051
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1211CytoplasmicUniRule annotationAdd
BLAST
Transmembranei13 – 3725HelicalUniRule annotationAdd
BLAST
Topological domaini38 – 6023PeriplasmicUniRule annotationAdd
BLAST
Transmembranei61 – 8121HelicalUniRule annotationAdd
BLAST
Topological domaini82 – 865CytoplasmicUniRule annotation
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Topological domaini108 – 14538PeriplasmicUniRule annotationAdd
BLAST
Transmembranei146 – 16823HelicalUniRule annotationAdd
BLAST
Topological domaini169 – 18113CytoplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 182181CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferasePRO_0000239131Add
BLAST

Proteomic databases

PaxDbiQ83R47.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF1955.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZQ. Bacteria.
COG0558. LUCA.
HOGENOMiHOG000010898.
KOiK00995.
OMAiVQMVAIP.
OrthoDBiEOG6WMJ3D.

Family and domain databases

HAMAPiMF_01437. PgsA.
InterProiIPR000462. CDP-OH_P_trans.
IPR023762. PGP_synthase_bac.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsiTIGR00560. pgsA. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83R47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFNIPTLLT LFRVILIPFF VLVFYLPVTW SPFAAALIFC VAAVTDWFDG
60 70 80 90 100
FLARRWNQST RFGAFLDPVA DKVLVAIAMV LVTEHYHSWW VTLPAATMIA
110 120 130 140 150
REIIISALRE WMAELGKRSS VAVSWIGKVK TTAQMVALAW LLWRPNIWVE
160 170 180
YVGIALFFVA AVLTLWSMLQ YLSAARADLL DQ
Length:182
Mass (Da):20,729
Last modified:January 23, 2007 - v3
Checksum:iA6E0502ABE6DDEA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43506.1.
AE014073 Genomic DNA. Translation: AAP17336.1.
RefSeqiNP_707799.1. NC_004337.2.
WP_001160190.1. NZ_LM651928.1.

Genome annotation databases

EnsemblBacteriaiAAN43506; AAN43506; SF1955.
AAP17336; AAP17336; S2051.
GeneIDi1025192.
KEGGisfl:SF1955.
sft:NCTC1_02126.
sfx:S2051.
PATRICi18705574. VBIShiFle31049_2275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43506.1.
AE014073 Genomic DNA. Translation: AAP17336.1.
RefSeqiNP_707799.1. NC_004337.2.
WP_001160190.1. NZ_LM651928.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF1955.

Proteomic databases

PaxDbiQ83R47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN43506; AAN43506; SF1955.
AAP17336; AAP17336; S2051.
GeneIDi1025192.
KEGGisfl:SF1955.
sft:NCTC1_02126.
sfx:S2051.
PATRICi18705574. VBIShiFle31049_2275.

Phylogenomic databases

eggNOGiENOG4105BZQ. Bacteria.
COG0558. LUCA.
HOGENOMiHOG000010898.
KOiK00995.
OMAiVQMVAIP.
OrthoDBiEOG6WMJ3D.

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503.

Family and domain databases

HAMAPiMF_01437. PgsA.
InterProiIPR000462. CDP-OH_P_trans.
IPR023762. PGP_synthase_bac.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsiTIGR00560. pgsA. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiPGSA_SHIFL
AccessioniPrimary (citable) accession number: Q83R47
Secondary accession number(s): Q7C173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.