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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene

pgsA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein catalyzes the committed step to the synthesis of the acidic phospholipids.UniRule annotation

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.UniRule annotation

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgsA), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgsA)
  2. Phosphatidylglycerophosphatase A (pgpA), Phosphatidylglycerophosphatase C (pgpC), Phosphatidylglycerophosphatase A (CEG98_17395), Phosphatidylglycerophosphatase B (pgpB)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseUniRule annotation (EC:2.7.8.5UniRule annotation)
Alternative name(s):
Phosphatidylglycerophosphate synthaseUniRule annotation
Short name:
PGP synthaseUniRule annotation
Gene namesi
Name:pgsAUniRule annotation
Ordered Locus Names:SF1955, S2051
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicUniRule annotationAdd BLAST11
Transmembranei13 – 37HelicalUniRule annotationAdd BLAST25
Topological domaini38 – 60PeriplasmicUniRule annotationAdd BLAST23
Transmembranei61 – 81HelicalUniRule annotationAdd BLAST21
Topological domaini82 – 86CytoplasmicUniRule annotation5
Transmembranei87 – 107HelicalUniRule annotationAdd BLAST21
Topological domaini108 – 145PeriplasmicUniRule annotationAdd BLAST38
Transmembranei146 – 168HelicalUniRule annotationAdd BLAST23
Topological domaini169 – 181CytoplasmicUniRule annotationAdd BLAST13

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002391312 – 182CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseAdd BLAST181

Family & Domainsi

Sequence similaritiesi

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZQ Bacteria
COG0558 LUCA
HOGENOMiHOG000010898
KOiK00995
OMAiIDYTIKY

Family and domain databases

HAMAPiMF_01437 PgsA, 1 hit
InterProiView protein in InterPro
IPR000462 CDP-OH_P_trans
IPR023762 PGP_synthase_bac
IPR004570 Phosphatidylglycerol_P_synth
PfamiView protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit
PIRSFiPIRSF000847 Phos_ph_gly_syn, 1 hit
TIGRFAMsiTIGR00560 pgsA, 1 hit
PROSITEiView protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83R47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFNIPTLLT LFRVILIPFF VLVFYLPVTW SPFAAALIFC VAAVTDWFDG
60 70 80 90 100
FLARRWNQST RFGAFLDPVA DKVLVAIAMV LVTEHYHSWW VTLPAATMIA
110 120 130 140 150
REIIISALRE WMAELGKRSS VAVSWIGKVK TTAQMVALAW LLWRPNIWVE
160 170 180
YVGIALFFVA AVLTLWSMLQ YLSAARADLL DQ
Length:182
Mass (Da):20,729
Last modified:January 23, 2007 - v3
Checksum:iA6E0502ABE6DDEA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN43506.1
AE014073 Genomic DNA Translation: AAP17336.1
RefSeqiNP_707799.1, NC_004337.2
WP_001160190.1, NZ_MTPK01000017.1

Genome annotation databases

EnsemblBacteriaiAAN43506; AAN43506; SF1955
AAP17336; AAP17336; S2051
GeneIDi1025192
KEGGisfl:SF1955
sfx:S2051
PATRICifig|198214.7.peg.2334

Similar proteinsi

Entry informationi

Entry nameiPGSA_SHIFL
AccessioniPrimary (citable) accession number: Q83R47
Secondary accession number(s): Q7C173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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